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2023 Bioscience, Biotechnology, and Biochemistry
Network Pharmacology Anticancer Melanoma
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Chinese Medicine Research Hub
Network Pharmacology
The ethanol extract from adzuki beans significantly reduces lung metastasis and invasion of melanoma cells, showing potential for functional food development.
2023 Bioscience, Biotechnology, and Biochemistry Potential Ability of Hot Water Adzuki (Vigna angularis) Extracts to Inhibit the Adhesion, Invasion, and Metastasis of Murine B16 Melanoma Cells
ITOH T, UMEKAWA H, FURUICHI Y
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Lung Metastasis" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Lung Metastasis" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Lung Metastasis" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Network Pharmacology published in 2023 in the journal Bioscience, Biotechnology, and Biochemistry found that The ethanol extract from adzuki beans significantly reduces lung metastasis and invasion of melanoma cells, showing potential for functional food development. The methodology of the study involved extracting the 40% ethanol eluent from the fraction of hot-water extract from adzuki beans adsorbed onto a type of resin. This extract, dubbed EtEx.40, was then tested on B16-BL6 melanoma cells, examining specifically its effects on adhesion, migration, and invasion into extracellular matrix components and their invasion into reconstituted basement membrane (colloquially referred to as matrigel), while ensuring it did not affect cell proliferation in vitro.
The results illustrated a significant difference in the presence of tumor colonies when treated with EtEx.40. The extract showed a considerable inhibitory effect on the experimental lung metastasis, as well as the invasion of the melanoma cells. Furthermore, the adhesion and migration of the melanoma cells into the extracellular matrix components were also reduced. The results demonstrated a strong antimetastatic role of the ethanol extract of adzuki beans.
