Beneficial role of insect-derived bioactive components against inflammation and its associated complications (colitis and arthritis) and cancer
Dutta P, Sahu RK, Dey T, Lahkar MD, Manna P, Kalita J · Chemico-Biological Interactions · 2019 November
DOI 10.1016/j.cbi.2019.108824
Objective
Insect-based bioactive components are emerging as novel sources of drugs, effective against various diseases. Recently, insect-based bioactive components, such as venoms, haemocytes, cecropin A, papiliocin, N-acetyldopamine dimers, cecropin-TY1 peptide, cop A3 peptide, glycosaminoglycan, coprisin peptide, silk fibroin microparticles, and silk fibroin nanoparticles have been found to be active against different inflammatory mechanisms and associated diseases. In this review, we will be discussing the role of different potential drug molecules of insect origin with special emphasis on anti-inflammation and their association with health disorders and cancer.
Conclusions
This review has provided an overview of the importance of insects and their bioactive molecules against inflammation and associated health disorders and cancer. Though, insect-derived drug molecules were shown to be promising in various in vitro and in vivo models, detailed knowledge behind their activities is still insufficient.
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