New substances of Equisetum hyemale L. extracts and their in vivo antitumoral effect against oral squamous cell carcinoma
de Queiroz LN, Da Fonseca ACC, Wermelinger GF, da Silva DPD, Pascoal ACRF, Sawaya ACHF, de Almeida ECP, do Amaral BS, de Lima Moreira D, Robbs BK · Journal of Ethnopharmacology · 2023 March
DOI 10.1016/j.jep.2022.116043
Objective
The aim of this study was to evaluate the antiproliferative activity of the ethanol extract of E. hyemale and its partitions in oral squamous carcinoma cell lines, the death pathways induced by the most active partition, the acute toxicity and therapeutic activity, and the identification of the main compounds.
Conclusions
In summary, the antitumor activity of four sample materials from E. hyemale in OSCC cell lines was tested. The ethanol extract showed selective cytotoxicity against OSCC, and this effect was increased in the EHSa partition, that showed high cytotoxic activity and very high selectivity. In the in vivo experiment, the partition was shown to be anti-tumor, significantly reducing tumor growth.
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