Virtual screening of the multi-gene regulatory molecular mechanism of Si-Wu-tang against non-triple-negative breast cancer based on network pharmacology combined with experimental validation
Zhang Z, Liu J, Liu Y, Shi D, He Y, Zhao P · Journal of Ethnopharmacology · 2021 April
DOI 10.1016/j.jep.2020.113696
Objective
Si-Wu-Tang (SWT), a prestigious herbal formula from China, has been extensively used for centuries for female-related diseases. This study aims to uncover the mechanism by which SWT treats non-TNBC by applying a network pharmacological method combined with experimental validation.
Conclusions
The biological mechanisms of their SWTs components in the body probably involve energy metabolism and apoptosis. There is convincing evidence that the mechanism by which SWT acts against non-TNBC is a direct or indirect synergy of multi-target and multi-pathway effects, which is consistent with our experimental verification.
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