Si Wu Tang

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Chinese Medicine Research Hub

Experimental Study

Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.

2022 Frontiers in Pharmacology Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation
Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang

Chinese Medicine Research Hub

Systematic Review

Siwutang (including its derived formulas) appears to be superior to conventional Western medicine for pain relief and in relation to response rate.

2020 Maturitas Chinese herbal formula siwutang for treating primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials
Li G, Liu A, Lin M, Liao S, Wen Z

Chinese Medicine Research Hub

Review Article

Traditional Chinese medicine, particularly Jia Wei Xiao Yao San, Yi Mu Cao and Si Wu Tang, are prevalently utilised treatments for Polycystic ovary syndrome (PCOS) by Taiwanese women.

2019 Medicine The prescription patterns of traditional Chinese medicine for women with polycystic ovary syndrome in Taiwan
Lin MJ, Chen HW, Liu PH, Cheng WJ, Kuo SL, Kao MC

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Si Wu Tang" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Si Wu Tang" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Si Wu Tang" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Experimental Study published in 2022 in the journal Frontiers in Pharmacology found that Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships. In the methodology of the study, a testosterone-treated MCF-7 cell model was employed to determine the effects of each herb in the SWT formula. Key metrics that were considered included the regulation of estradiol, antioxidative effects, and the total polyphenol and polysaccharide contents as quality markers. The study also explored the potential ability of certain elements within the formula to act as an aromatase promoter, notably catalpol and other elements. In terms of results, certain herbs in SWT such as catalpol showed an ability to significantly increase estradiol content and boost upregulation in cell culture, indicating their role as potential aromatase promoters within the formula. Antioxidant activity was also strong in other compounds like pentagalloylglucose, gallic acid, and ferulic acid. These antioxidative effects were attributed to the presence of polyphenols in the herbs. Furthermore, the herb with the strongest antioxidant effects could possibly help ameliorate menstrual disorder patterns due to its ability to prevent ROS damage to the ovaries.

A Systematic Review published in 2020 in the journal Maturitas found that Siwutang (including its derived formulas) appears to be superior to conventional Western medicine for pain relief and in relation to response rate. This systematic review and meta-analysis assessed the efficacy and safety of Siwutang (SWT), a Chinese herbal formula, for treating primary dysmenorrhea. Among 523 initially identified citations, 39 studies were included in the qualitative synthesis, and 38 were used for meta-analysis. Results indicated that SWT demonstrated superiority over conventional western medicine in terms of pain relief and response rate. Notably, SWT and its derivative formulas exhibited higher response rates compared to conventional medicine, with moderate heterogeneity (I2 = 48%). SWT was particularly effective in reducing pain intensity when compared to conventional medicine (MD: -2.61, 95% CI: -3.72 to -1.51). Additionally, the safety profile of SWT appeared to be advantageous, with a lower incidence of adverse events than conventional medicine (RR: 0.17, 95% CI: 0.07−0.38). However, the quality of the included trials was generally low, with methodological limitations including inadequate reporting of randomization and blinding procedures. As a result, the level of evidence was deemed low due to the high risk of bias. The authors concluded that while SWT demonstrated promise for treating primary dysmenorrhea, further well-designed clinical trials with larger sample sizes are necessary to establish its effectiveness and safety more conclusively. Notably, the lack of standardized outcome measures and the inconsistent reporting of response rates across studies highlighted the need for the development and implementation of a core outcome set for primary dysmenorrhea research.

A Review Article published in 2019 in the journal Medicine found that Traditional Chinese medicine, particularly Jia Wei Xiao Yao San, Yi Mu Cao and Si Wu Tang, are prevalently utilised treatments for Polycystic ovary syndrome (PCOS) by Taiwanese women. The research involved an investigation into the use of Traditional Chinese Medicine (TCM) by Taiwanese women suffering from Polycystic ovary syndrome (PCOS). Data for the study was gathered from the Longitudinal Health Insurance Database for the years 2000 and 2005. The researchers analyzed the demographic characteristics of the participants, the extent of TCM usage, and the frequency and average daily intake of particular Chinese herbal formulas and single herbs. The results indicated that 66.43% of the women reached out for TCM in managing PCOS and most especially in treating infertility or menstrual issues. The most commonly prescribed Chinese herbal formula was Jia-wei-xiao-yao-san, while Yi-mu-cao topped the list of the most commonly utilized single herb. Among the top 20 Chinese herbal formulas, Si-wu-tang was noted for its highest average daily dosage. The study effectively highlighted the preferences and prescription patterns relating to TCM for patients with PCOS in Taiwan.

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