Chilli

Presentation Slides

Chinese Medicine Research Hub

Systematic Review

Epidemiological studies suggest that the consumption of spicy chilli food is associated with reduced risk of all-cause as well as heart disease–related mortality.

2021 Angiology Association of Spicy Chilli Food Consumption With Cardiovascular and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies
Ofori-Asenso R, Mohsenpour MA, Nouri M, Faghih S, Liew D, Mazidi M.

Chinese Medicine Research Hub

Systematic Review

Chili pepper has preventive and therapeutic properties for many ailments such as different types of cancer, rheumatism, stiff joints, bronchitis and chest colds with cough and headache, arthritis, heart arrhythmias and used as stomachic.

2018 MOJ Food Processing & Technology Medicinal uses and health benefits of chili pepper (Capsicum spp.) : a review
Saleh BK, Omer A, Teweldemedhin B.

Chinese Medicine Research Hub

Review Article

Previous records suggest pleiotropic pharmacological activities of capsaicin such as an analgesic, anti-obesity, anti-pruritic, anti-inflammatory, anti-apoptotic, anti-cancer, anti-oxidant, and neuro-protective functions. Emerging data indicate its clinical significance in treating vascular-related diseases, metabolic syndrome, and gastro-protective effects.

2016 Molecules Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
Basith S, Cui M, Hong S, Choi S

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Chilli" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Chilli" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Chilli" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2021 in the journal Angiology found that Epidemiological studies suggest that the consumption of spicy chilli food is associated with reduced risk of all-cause as well as heart disease–related mortality. This systematic review and meta-analysis examined the association between spicy food (chilli pepper, chilli sauce, or chilli oil) consumption with cardiovascular and all-cause mortality. Medline and EMBASE were searched from their inception until February 2020 to identify relevant prospective cohort studies. Hazard ratios (HRs)/relative risk (RRs) were pooled via random-effect meta-analysis. Of the 4387 citations identified, 4 studies (from the United States, China, Italy, and Iran) were included in the meta-analysis. The included studies involved a total of 564 748 adults (aged ≥18 years; 51.2% female) followed over a median duration of 9.7 years. The pooled data suggested that compared with people who did not regularly consume spicy food (none/<1 d/wk), regular consumers of spicy food experienced a 12% (HR/RRpooled 0.88, 95% CI, 0.86-0.90; I 2 = 0%) lower risk of all-cause mortality. Moreover, spicy food consumption was associated with significant reduction in the risk of death from cardiac diseases (HR/RRpooled 0.82, 0.73-0.91; I 2 = 0%), but not from cerebrovascular disorders (HR/RRpooled 0.79, 0.53-1.17; I 2 = 72.2%). In conclusion, available epidemiological studies suggest that the consumption of spicy chilli food is associated with reduced risk of all-cause as well as heart disease–related mortality. Further studies in different populations are needed to confirm this association.

A Systematic Review published in 2018 in the journal MOJ Food Processing & Technology found that Chili pepper has preventive and therapeutic properties for many ailments such as different types of cancer, rheumatism, stiff joints, bronchitis and chest colds with cough and headache, arthritis, heart arrhythmias and used as stomachic. A vanilloid receptor known as VR1 which was later found to be member of the family TRP and was called TRPV1 (transient receptor potential vanilloid subtype 1) is the receptor for capsaicin and is universally distributed in the brain, sensory nerves, dorsal root ganglia, bladder, gut, and blood vessels. Capsaicin is activate and then desensitize or block VR1 and was found to be powerful drug in animal models of human disease. Capsaicin plays a potential role in cardiometabolic protection through the activation of TRPV1 in different target organs or tissues, which suggests that TRPV1 may be a promising target for the management of cardiometabolic diseases such as obesity, hypertension, dyslipidemia, diabetes and atherosclerosis. However, association between the dosage of dietary capsaicin and the effect on cardiometabolic protection need to be clarified for determining the daily usage or intake of capsaicin or its derivatives. The activation of VR1 by capsaicin make it possible to be involved in various human disease states ranging from genetic pain insensitivity to chronic pain syndromes. In addition to that VR1 has much broader clinical benefits than mere pain case. Chili pepper has preventive and therapeutic properties for many ailments such as different types of cancer, rheumatism, stiff joints, bronchitis and chest colds with cough and headache, arthritis, heart arrhythmias and used as stomachic. Chili preparations for treating ailments can be standard capsaicin, pharmaceutically prepared gels, creams and plasters, essential oils distilled from pods, powder prepared by crashing pods and extracts by soaking pods in water or ethanol.

A Review Article published in 2016 in the journal Molecules found that Previous records suggest pleiotropic pharmacological activities of capsaicin such as an analgesic, anti-obesity, anti-pruritic, anti-inflammatory, anti-apoptotic, anti-cancer, anti-oxidant, and neuro-protective functions. Emerging data indicate its clinical significance in treating vascular-related diseases, metabolic syndrome, and gastro-protective effects. Capsaicin has elicited enormous interest for several centuries due to its conspicuous culinary and clinical applications. Despite its adverse effects, capsaicin is still being used as an active principle in several pharmaceutical formulations for treating various human ailments. Moreover, emerging studies have shown that capsaicin is implicated in a broader range of functions than previously anticipated. Even though it is best characterized in the field of nociception and pain, several experimental and clinical studies also demonstrate its role in other important pathological states like cancer, obesity, skin disorders, cardiovascular diseases, etc. Additionally, it has also been implicated in other activities including treatment of the upper respiratory reflexes, prevention of adipogenesis, boosting metabolic rate, and regulation of innate and adaptive immune responses.

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