Extra Virgin Olive Oil
Also known as: EVOO
Recent Insights
High phenolic early harvest extra virgin olive oil shows notable improvement in cognitive function compared to a moderate phenolic version and the Mediterranean diet alone.
Alzheimer's Disease Cognitive Function Extra Virgin Olive Oil
The Mediterranean diet, especially the high consumption of extra-virgin olive oil, significantly reduces the risks of vascular diseases and Alzheimer's.
Alzheimer's Disease Extra Virgin Olive Oil Mediterranean Diet
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Extra Virgin Olive Oil (EVOO), a Mediterranean Diet Component, in the Management of Muscle Mass and Function Preservation
2022 Aug 30 Nutrients Salucci S, Bartoletti-Stella A, Bavelloni A, Aramini B, Blalock WL, Fabbri F, et al.
The review suggests that due to its anti-inflammatory and antioxidative properties, EVOO supplementation has the potential to delay/prevent the loss of muscle mass and function associated with sarcopenia in aging individuals, emphasizing the need for further research to assess its effectiveness in dietary supplementation.
Theoretical Article Review Article Muscle Mass
The clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach
2022 Aug 04 Frontiers in Nutrition Seidita A, Soresi M, Giannitrapani L, Di Stefano V, Citarrella R, Mirarchi L, et al.
The study concludes that the Mediterranean diet (MD) enriched with extra virgin olive oil (EVOO) offers potential health benefits, including antioxidant, anti-inflammatory, insulin-sensitizing, cardioprotective, antiatherogenic, neuroprotective, immunomodulatory, and anticancer activities. However, the authors emphasize the need for further research to fully understand the clinical efficacy and the underlying biochemical and molecular mechanisms of EVOO in treating metabolic syndrome and its associated complications.
Review Article Metabolic Syndrome Extra Virgin Olive OilTherapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update
2022 Mar 31 Nutrients Jiménez-Sánchez A, Martínez-Ortega AJ, Remón-Ruiz PJ, Piñar-Gutiérrez A, Pereira-Cunill JL, García-Luna PP
Review Article Type 2 Diabetes Cardiovascular DiseaseExtra virgin olive oil (EVOO) has beneficial health properties and can promote cardiovascular health, lipoprotein metabolism, and diabetes management in clinical nutrition.
Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms
2022 Jan 12 Molecules Moral R, Escrich E
The experimental in vivo and in vitro data suggest that EVOO and its compounds, through various mechanisms including changes in epigenetics, transcriptome, and protein expression, exhibit a protective effect on mammary carcinogenesis, making EVOO in the context of the Mediterranean diet a healthy choice and its components promising adjuvants in anticancer strategies.
Experimental Study Review Article Olive Oil Breast Cancer Extra Virgin Olive Oil
Effect of extra virgin olive oil consumption on glycemic control: A systematic review and meta-analysis
2021 Jun Nutrition, Metabolism and Cardiovascular Diseases Dehghani F, Morvaridzadeh M, Pizarro AB, Rouzitalab T, Khorshidi M, Izadi A, et al.
EVOO intake had no significant effect on fasting blood glucose, insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), but a decreasing trend was observed.
Systematic Review Meta-Analysis Glycaemic Control Extra Virgin Olive Oil Blood SugarResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Extra virgin olive oil (EVOO) has beneficial health properties and can promote cardiovascular health, lipoprotein metabolism, and diabetes management in clinical nutrition.
2022 Nutrients Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update Jiménez-Sánchez A, Martínez-Ortega AJ, Remón-Ruiz PJ, Piñar-Gutiérrez A, Pereira-Cunill JL, García-Luna PP
Review Article Cardiovascular Disease Type 2 Diabetes
The methodology of this narrative review involved an extensive synthesis and illustration of the various characteristics and clinical applications of EVOO and its components such as oleic acid, hydroxytyrosol, and oleuropein. It looked at their significance in diet therapy, use in oleic acid-based enteral and parenteral nutrition formulations, and oral supplementation formulations.
In their discussion of the results, the researchers found diverse health benefits associated with EVOO. Particularly, they highlighted the potential of whole EVOO in diet therapy and its minor components in supplementation to enhance cardiovascular health, control lipoprotein metabolism, and manage diabetes mellitus within a clinical nutrition framework. It was seen as a significant addition to nutritional and dietary strategies, with a potential for therapeutic application in several diseases and clinical demographics.
Extra virgin olive oil high in minor polar compounds significantly improves kidney function, reduces oxidative stress, inflammation, and ultimately benefits the body composition.
2021 Nutrients Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients Noce A, Marrone G, Urciuoli S, Di Daniele F, Di Lauro M, Pietroboni Zaitseva A, et al.
Experimental Study Chronic Kidney Disease
The research study tested two distinct types of extra virgin olive oils, namely Synergy with a high content and Luxolio with a medium content of minor polar compounds, on 40 patients suffering from kidney disease. The patients were administered a 40 mL dosage per day over nine weeks. Researchers assessed the impacts on renal functionality, oxidative stress, inflammation levels, and body composition, before and after a subsequent two-month wash out period. Additionally, the concentration of minor polar compounds in the oils was determined through high-performance liquid chromatography accompanied by diode-array detection and mass spectrometry (HPLC-DAD-MS).
The research showed improvements in kidney function indicators such as estimated glomerular filtration rate, albuminuria, azotemia, and uric acid. Further, the patients' lipid profile also improved, as did their inflammation parameters, erythrocyte sedimentation rate, C-reactive protein, and body composition. More notably, these beneficial effects were stronger and lasted longer in those patients who had been given the Synergy oil, indicating a sustained antioxidant and anti-inflammatory impact from EVOOs with higher concentrations of minor polar compounds.
High phenolic early harvest extra virgin olive oil shows notable improvement in cognitive function compared to a moderate phenolic version and the Mediterranean diet alone.
2020 Journal of Alzheimer's Disease A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study Tsolaki M, Lazarou E, Kozori M, Petridou N, Tabakis I, Lazarou I, et al.
Clinical Study Alzheimer's Disease Cognitive Function
A randomized prospective study was conducted examining the effects of high phenolic early harvest extra virgin olive oil (HP-EH-EVOO) and moderate phenolic extra virgin olive oil (MP-EVOO) against the Mediterranean Diet (MeDi) in individuals with mild cognitive impairment. Participants were genetically tested for susceptibility to Alzheimer's disease and had their cognitive functions tested at the start and after 12 months. They were then randomly put into one of three groups: those who received HP-EH-EVOO, those who received MP-EVOO, and those who only received instructions on following the MeDi.
The results showed that participants who consumed HP-EH-EVOO demonstrated better cognitive performance in almost all areas over the course of the study, compared to those who consumed MP-EVOO and those who followed the MeDi. MP-EVOO consumers also demonstrated noticeable cognitive improvement compared to the MeDi group, who exhibited worse or similar cognitive performance to their baseline in almost all areas. Moreover, participants who consumed either form of olive oil performed better in cognitive tests, regardless of their predisposition to Alzheimer's disease.
The Mediterranean diet, especially the high consumption of extra-virgin olive oil, significantly reduces the risks of vascular diseases and Alzheimer's.
2019 Revue Neurologique Extra-virgin olive oil for potential prevention of Alzheimer disease Román GC, Jackson RE, Reis J, Román AN, Toledo JB, Toledo E
Review Article Alzheimer's Disease Mediterranean Diet
The research has been based on a plethora of observational epidemiological studies, local population experiences, meta-analyses of epidemiologic data, and experimental studies, all converging to the connection between the Mediterranean diet and a reduced prevalence of different ailments. The study scopes extend over long periods, such as the Italian-American experience from 1935 to 1965, or the Seven Countries Study spanning four decades from 1960 to 2000. Another significant evidence base is the French Three-City Study, which followed participants for ten years from 2000 to 2010. Apart from human trials, the article includes results from experimental animal models, specifically concerning late-onset Alzheimer disease.
The findings showcase a consistent trend linking reduction in vascular diseases, obesity, arthritis, cancer, cognitive decline, and specifically Alzheimer's disease with increased adherence to a Mediterranean dietary pattern, particularly high intake of extra-virgin olive oil. Certain dietary components such as fruits, seeds, legumes, and vegetables contribute to the benefits. However, olive oil stands out as the chief dietary fat in Mediterranean countries. It provides plentiful monounsaturated fatty acids, beneficial polyphenols, and other antioxidants, which play a crucial part in these health benefits. The most striking discovery is extra-virgin olive oil's potential to mitigate the effects of adverse vascular factors, indicating a promising approach to preventing late-onset Alzheimer's disease.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Extra Virgin Olive Oil (EVOO), a Mediterranean Diet Component, in the Management of Muscle Mass and Function Preservation
2022 Aug 30 Nutrients Salucci S, Bartoletti-Stella A, Bavelloni A, Aramini B, Blalock WL, Fabbri F, et al.
The review suggests that due to its anti-inflammatory and antioxidative properties, EVOO supplementation has the potential to delay/prevent the loss of muscle mass and function associated with sarcopenia in aging individuals, emphasizing the need for further research to assess its effectiveness in dietary supplementation.
Theoretical Article Review Article Muscle MassThe clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach
2022 Aug 04 Frontiers in Nutrition Seidita A, Soresi M, Giannitrapani L, Di Stefano V, Citarrella R, Mirarchi L, et al.
The study concludes that the Mediterranean diet (MD) enriched with extra virgin olive oil (EVOO) offers potential health benefits, including antioxidant, anti-inflammatory, insulin-sensitizing, cardioprotective, antiatherogenic, neuroprotective, immunomodulatory, and anticancer activities. However, the authors emphasize the need for further research to fully understand the clinical efficacy and the underlying biochemical and molecular mechanisms of EVOO in treating metabolic syndrome and its associated complications.
Review Article Metabolic Syndrome Extra Virgin Olive OilTherapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update
2022 Mar 31 Nutrients Jiménez-Sánchez A, Martínez-Ortega AJ, Remón-Ruiz PJ, Piñar-Gutiérrez A, Pereira-Cunill JL, García-Luna PP
Review Article Type 2 Diabetes Cardiovascular DiseaseExtra virgin olive oil (EVOO) has beneficial health properties and can promote cardiovascular health, lipoprotein metabolism, and diabetes management in clinical nutrition.
Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms
2022 Jan 12 Molecules Moral R, Escrich E
The experimental in vivo and in vitro data suggest that EVOO and its compounds, through various mechanisms including changes in epigenetics, transcriptome, and protein expression, exhibit a protective effect on mammary carcinogenesis, making EVOO in the context of the Mediterranean diet a healthy choice and its components promising adjuvants in anticancer strategies.
Experimental Study Review Article Olive Oil Breast Cancer Extra Virgin Olive OilEffect of extra virgin olive oil consumption on glycemic control: A systematic review and meta-analysis
2021 Jun Nutrition, Metabolism and Cardiovascular Diseases Dehghani F, Morvaridzadeh M, Pizarro AB, Rouzitalab T, Khorshidi M, Izadi A, et al.
EVOO intake had no significant effect on fasting blood glucose, insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), but a decreasing trend was observed.
Systematic Review Meta-Analysis Glycaemic Control Extra Virgin Olive Oil Blood SugarClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study
2020 Nov 10 Journal of Alzheimer's Disease Tsolaki M, Lazarou E, Kozori M, Petridou N, Tabakis I, Lazarou I, et al.
Clinical Study Randomised Controlled Trial Extra Virgin Olive Oil Cognitive Function Alzheimer's DiseaseHigh phenolic early harvest extra virgin olive oil shows notable improvement in cognitive function compared to a moderate phenolic version and the Mediterranean diet alone.
The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis
2020 Jan 03 European Journal of Clinical Nutrition Morvaridi M, Jafarirad S, Seyedian SS, Alavinejad P, Cheraghian B
Extra virgin olive oil (EVOO) consumption led to a significant decrease in inflammatory markers (erythrocyte sedimentation rate and high-sensitivity C-reactive protein) and improved gastrointestinal symptoms, including reduced bloating, constipation, fecal urgency, incomplete defecation, and overall gastrointestinal symptom severity in ulcerative colitis (UC) patients.
Clinical Study Randomised Controlled Trial Ulcerative ColitisPresentation Slides
Extra virgin olive oil (EVOO) has beneficial health properties and can promote cardiovascular health, lipoprotein metabolism, and diabetes management in clinical nutrition.
Extra virgin olive oil high in minor polar compounds significantly improves kidney function, reduces oxidative stress, inflammation, and ultimately benefits the body composition.
High phenolic early harvest extra virgin olive oil shows notable improvement in cognitive function compared to a moderate phenolic version and the Mediterranean diet alone.
The Mediterranean diet, especially the high consumption of extra-virgin olive oil, significantly reduces the risks of vascular diseases and Alzheimer's.
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