Anaemia
Recent Insights
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
Anaemia Haemoglobin Honey
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
Anaemia Erythropoietin Iron
Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Anaemia Erythropoietin Iron
Maintenance of sufficient vitamin D status may be important in preventing anemia, particularly in diseases characterized by inflammation.
Anaemia Ferritin Vitamin D
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia
2022 Aug 04 Journal of Asian Multicultural Research for Medical and Health Science Study A A, Astuti A, Leli L, Saad R
Randomised Controlled Trial Anaemia Pregnancy Honey HaemoglobinHoney, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
Iron deficiency without anaemia: a diagnosis that matters
2021 Mar Clinical Medicine Al-Naseem A, Sallam A, Choudhury S, Thachil J
The review concludes that IDWA is poorly recognized by clinicians despite its high prevalence, emphasizes the importance of iron sufficiency during pregnancy, highlights the need for preoperative correction of IDWA to reduce transfusion and postoperative anaemia risk, and recommends oral iron as the first-line treatment, with intravenous supplementation in specific situations.
Review ArticleA Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
2020 Nov 26 Frontiers in Pharmacology Chen J, Tsim KWK
Review Article Anaemia Iron ErythropoietinFlavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia
2020 Nov 02 JAMA Oncology Li N, Zhao G, Wu W, Zhang M, Liu W, Chen Q, et al.
Among patients with IDA, oral iron supplements alone were equivalent to oral iron supplements plus vitamin C in improving hemoglobin recovery and iron absorption. These findings suggest that on-demand vitamin C supplements are not essential to take along with oral iron supplements for patients with IDA.
Randomised Controlled Trial Anaemia Vitamin C Iron Deficiency Anaemia
Efficacy and safety of Danggui Buxue Decoction in combination with western medicine treatment of anemia for renal anemia: a systematic review and meta-analysis
2017 Mar Annals of Translational Medicine Zhao MM, Zhang Y, Li LS, Yu ZK, Li B
Danggui Buxue Decoction in combination with conventional western medicine (CWM) for renal anemia might be superior to CWM alone and there was no adverse event in the experimental group, it might be more effective when the ratio of Radix Astragali to Radix Angelicae Sinensis was 5:1. However, the quality of included studies was not high, and less attention was paid to the safety, high quality randomized controlled trials are needed to further confirm the findings.
Systematic Review Meta-Analysis Anaemia Renal AnemiaResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
2022 Journal of Asian Multicultural Research for Medical and Health Science Study Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia A A, Astuti A, Leli L, Saad R
Randomised Controlled Trial Haemoglobin Honey Pregnancy
This quasi-experimental study with a pretest-posttest design involved 30 pregnant women divided into two groups: one receiving Fe (Control Group) and the other Honey + Fe (Intervention Group) for 60 days. Blood and urine analyses revealed a remarkable increase in hemoglobin levels in the Honey + Fe group (2.80 ± 0.26 g/dl), surpassing the Fe control group (0.80 ± 0.13 g/dl). Moreover, the Intervention Group demonstrated a notable decrease in 8-Ohdg levels (-4.23 ± 1.32 nmol/ml, p = 0.031), indicating reduced oxidative stress, while the Fe control group exhibited less significant changes (2.98 ± 1.30 nmol/ml, p = 0.322). Independent T Test confirmed the Honey + Fe group's superior effectiveness in increasing hemoglobin levels and decreasing 8-Ohdg levels in anemic pregnant women (p = 0.001 and p = 0.002, respectively).
The study underscores the synergistic benefits of honey and iron supplementation in enhancing hemoglobin levels and mitigating oxidative stress among anemic pregnant women. The robust findings, supported by statistical significance, emphasize the potential clinical relevance of incorporating honey into anemia management strategies, offering a more effective approach compared to iron supplementation alone.
Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence Chen J, Tsim KWK
Review Article Erythropoietin Iron
Jujube promotes erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, possesses potential capacity in recycling heme iron during erythrophagocytosis, exhibits bidirectional role in regulating immune response under different conditions, contains numerous minerals including iron.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence Chen J, Tsim KWK
Review Article Erythropoietin Iron
Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. Thus, the blood-nourishing function of jujube is being proposed here. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia.
Maintenance of sufficient vitamin D status may be important in preventing anemia, particularly in diseases characterized by inflammation.
2015 Current Opinion in Endocrinology, Diabetes & Obesity Vitamin D and anemia Smith EM, Tangpricha V
Review Article Ferritin Vitamin D
Vitamin D has previously been found to be associated with anemia in various healthy and diseased populations. Recent studies indicate that the association may differ between race and ethnic groups and is likely specific to anemia of inflammation. The mechanism underlying this association involves the reduction of proinflammatory cytokines by vitamin D and the direct suppression of hepcidin mRNA transcription. There is also evidence that vitamin D may be protective against anemia by supporting erythropoiesis. Other calciotropic hormones including fibroblast growth factor 23, and parathyroid hormone have also been found to be associated with iron homeostasis and erythropoiesis.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Iron deficiency without anaemia: a diagnosis that matters
2021 Mar Clinical Medicine Al-Naseem A, Sallam A, Choudhury S, Thachil J
The review concludes that IDWA is poorly recognized by clinicians despite its high prevalence, emphasizes the importance of iron sufficiency during pregnancy, highlights the need for preoperative correction of IDWA to reduce transfusion and postoperative anaemia risk, and recommends oral iron as the first-line treatment, with intravenous supplementation in specific situations.
Review ArticleA Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
2020 Nov 26 Frontiers in Pharmacology Chen J, Tsim KWK
Review Article Anaemia Iron ErythropoietinFlavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
Efficacy and safety of Danggui Buxue Decoction in combination with western medicine treatment of anemia for renal anemia: a systematic review and meta-analysis
2017 Mar Annals of Translational Medicine Zhao MM, Zhang Y, Li LS, Yu ZK, Li B
Danggui Buxue Decoction in combination with conventional western medicine (CWM) for renal anemia might be superior to CWM alone and there was no adverse event in the experimental group, it might be more effective when the ratio of Radix Astragali to Radix Angelicae Sinensis was 5:1. However, the quality of included studies was not high, and less attention was paid to the safety, high quality randomized controlled trials are needed to further confirm the findings.
Systematic Review Meta-Analysis Anaemia Renal AnemiaVitamin D and anemia
2015 Dec Current Opinion in Endocrinology, Diabetes & Obesity Smith EM, Tangpricha V
Review Article Vitamin D Ferritin AnaemiaMaintenance of sufficient vitamin D status may be important in preventing anemia, particularly in diseases characterized by inflammation.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia
2022 Aug 04 Journal of Asian Multicultural Research for Medical and Health Science Study A A, Astuti A, Leli L, Saad R
Randomised Controlled Trial Anaemia Pregnancy Honey HaemoglobinHoney, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia
2020 Nov 02 JAMA Oncology Li N, Zhao G, Wu W, Zhang M, Liu W, Chen Q, et al.
Among patients with IDA, oral iron supplements alone were equivalent to oral iron supplements plus vitamin C in improving hemoglobin recovery and iron absorption. These findings suggest that on-demand vitamin C supplements are not essential to take along with oral iron supplements for patients with IDA.
Randomised Controlled Trial Anaemia Vitamin C Iron Deficiency AnaemiaPresentation Slides
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
Maintenance of sufficient vitamin D status may be important in preventing anemia, particularly in diseases characterized by inflammation.
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