Diarrhoea

Presentation Slides

Chinese Medicine Research Hub

Systematic Review

Traditional Chinese medicine therapies, like acupuncture and moxibustion, effectively alleviate irritable bowel syndrome with diarrhea symptoms, and reduce recurrence rates.

2022 Frontiers in Medicine External therapy of traditional Chinese medicine for treating irritable bowel syndrome with diarrhea: A systematic review and meta-analysis
Wei X, Wen Y, Wei Y, Liang X, Ma X, Zhang B, Tang X

Chinese Medicine Research Hub

Meta-Analysis

Acupuncture combined with moxibustion showed the best outcomes in terms of efficacy and quality of life improvement for adults with irritable bowel syndrome complicated with diarrhea.

2022 Computational and Mathematical Methods in Medicine Acupuncture and Moxibustion in the Treatment of Adult Diarrhea Irritable Bowel Syndrome: A Network Meta-analysis
Jiang X, Guo X, Zhou J, Ye S

Chinese Medicine Research Hub

Clinical Study

The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.

2022 Journal of Acupuncture and Tuina Science Clinical study on Tuina plus Shen Ling Bai Zhu San in treating children with diarrhea due to spleen deficiency
Li J

Chinese Medicine Research Hub

Systematic Review

Acupuncture treatment can improve the clinical effectiveness of diarrhea-predominant irritable bowel syndrome or functional diarrhea.

2020 Neural Plasticity Acupuncture for Adults with Diarrhea-Predominant Irritable Bowel Syndrome or Functional Diarrhea: A Systematic Review and Meta-Analysis
Jianbo Guo, Xiaoxiao Xing, Jiani Wu, Hui Zhang, Yongen Yun, Zongshi Qin, and Qingyong He

Chinese Medicine Research Hub

Randomised Controlled Trial

Dark chocolate with high cocoa content can affect colonic functionality and stimulate certain brain regions in healthy adults.

2019 British Journal of Nutrition Effect of cocoa on the brain and gut in healthy subjects: a randomised controlled trial
Fox M, Meyer-Gerspach AC, Wendebourg MJ, Gruber M, Heinrich H, Sauter M, Woelnerhanssen B, Koeberle D, Juengling F

Chinese Medicine Research Hub

Systematic Review

Acupuncture may improve diarrhoea-predominant irritable bowel syndrome better than drugs and has the fewest side effects.

2018 Evidence-Based Complementary and Alternative Medicine Acupuncture for Diarrhoea-Predominant Irritable Bowel Syndrome: A Network Meta-Analysis
Zhu L, Ma Y, Ye S, Shu Z

Chinese Medicine Research Hub

Clinical Study

Drinking alkaline-reduced water can improve the quality of life in patients suffering from diarrhea-predominant irritable bowel syndrome.

2018 Evidence-Based Complementary and Alternative Medicine Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study
Shin DW, Yoon H, Kim HS, Choi YJ, Shin CM, Park YS, Kim N, Lee DH

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Diarrhoea" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Diarrhoea" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Diarrhoea" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2022 in the journal Frontiers in Medicine found that Traditional Chinese medicine therapies, like acupuncture and moxibustion, effectively alleviate irritable bowel syndrome with diarrhea symptoms, and reduce recurrence rates. Adhering to the guidelines for systematic reviews, multiple databases including PubMed and Cochrane Library, and several Chinese databases were thoroughly searched. The focus was randomized controlled trials that compared traditional Chinese external therapies with western medicine for irritable bowel syndrome with diarrhea up until the end of 2021. Two authors were independently responsible for screening, data extraction and study assessment. Study quality assessment involved both the Jadad scale and Cochrane Collaborative's risk of bias tool. Meta-analysis was performed on the data collated using Review Manager software. The gathered data revealed that of the twenty-one studies examined, including a total of 1,862 subjects, acupuncture and moxibustion were the most prevalent external therapies. The results of the meta-analysis indicated that in comparison to the control group, the experimental group demonstrated marked improvement. Notably, the experimental group had superior clinical effectiveness rates, better clinical cure rates, and reduced recurrence. Additionally, there was significant improvement in irritable bowel syndrome related quality of life within the experimental group. Despite these promising results, the publication bias of the included studies was noted as a potential limitation.

A Meta-Analysis published in 2022 in the journal Computational and Mathematical Methods in Medicine found that Acupuncture combined with moxibustion showed the best outcomes in terms of efficacy and quality of life improvement for adults with irritable bowel syndrome complicated with diarrhea. The study was conducted by searching major databases, including PubMed, The Cochrane Library, Embase, and database from China, for randomized controlled trials. These trials explored the effects of acupuncture and moxibustion on individuals suffering from irritable bowel syndrome complicated with diarrhea. The selected studies underwent a rigorous bias assessment and their data were analyzed using Stata 16.0 statistical software. The analysis encompassed 21 studies overall, considering 1626 patients undergoing 8 different therapeutic measures. The study found that treatments such as acupuncture, warming needle moxibustion, and a combination of acupuncture with sandwiched or heat-sensitive moxibustion revealed significantly improved outcomes when compared to the drug pinaverium bromide. On the other hand, pinaverium bromide demonstrated the lowest efficacy and effect on quality of life. The most frequently used acupuncture points were GV20, GV29, ST 25, ST37, ST36, SP6, LR3, and CV12.

A Clinical Study published in 2022 in the journal Journal of Acupuncture and Tuina Science found that The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone. Methodology: The paper reports on a clinical trial involving a total of 105 children diagnosed with diarrhea due to spleen deficiency. These children were randomly allocated into two separate groups: a control group and an observation group. The control group, consisting of 52 children, were exclusively treated with Shen Ling Bai Zhu San orally. The observation group, on the other hand, consisted of 53 children who received an additional Tuina treatment along with Shen Ling Bai Zhu San. Results: After implementing the treatments, it was found that every child in the observation group showed improvement, compared to 90% improvement rate in the control group. This correlated to a decrease in scores of primary and secondary symptoms of traditional Chinese medicine in both groups post-treatment. Furthermore, the children in the observation group who received both treatments had even lower symptom scores than the control group who only received Shen Ling Bai Zhu San. The treatments were also well-tolerated with no significant adverse reactions reported.

A Systematic Review published in 2020 in the journal Neural Plasticity found that Acupuncture treatment can improve the clinical effectiveness of diarrhea-predominant irritable bowel syndrome or functional diarrhea. In this systematic review and meta-analysis, the effectiveness and safety of 31 acupuncture concerned studies for patients with IBS-D or FD were evaluated. We found that acupuncture can significantly reduce the number of stools per week in IBS-D or FD patients, improve patients’ overall symptoms, improve the total effective rate, decrease the recurrence rate, and reduce the pain level of patients. Based on the results, we believe that acupuncture can improve the quality of life of patients with IBS-D or FD. Although the number of adverse events in the acupuncture group was similar to that in the control group, the majority of adverse events in the acupuncture group were subcutaneous hemorrhage. With such slight adverse events, we have observed that acceptance among patients has not been reduced. Moreover, the withdrawal rate of patients in the acupuncture group was still slightly lower than that in the control group.

A Randomised Controlled Trial published in 2019 in the journal British Journal of Nutrition found that Dark chocolate with high cocoa content can affect colonic functionality and stimulate certain brain regions in healthy adults. The study involved a controlled, randomised experiment including healthy volunteers who were given 100g of either dark chocolate (with 72% cocoa content) or white chocolate (with no cocoa content) for five consecutive days. The volunteers then recorded any abdominal symptoms and stool consistency using the Bristol Stool Score. Gastric emptying as well as intestinal and colonic transit time were examined using scintigraphy and marker studies, while the activity in different brain regions was assessed using combined positron emission tomography-computed tomography imaging techniques. The study found that dark chocolate did not alter the functionality of the upper gastrointestinal tract. Nevertheless, it was observed that the consumption of dark chocolate led to harder stool consistency. As for the brain, an increased uptake of fluorodeoxyglucose was noticed within the visual cortex, with other regions like the somatosensory, motor and pre-frontal cortices also showing heightened activity. This suggests that dark chocolate may potentially influence certain brain functions.

A Systematic Review published in 2018 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture may improve diarrhoea-predominant irritable bowel syndrome better than drugs and has the fewest side effects. Acupuncture may improve diarrhoea-predominant irritable bowel syndrome better than drugs and has the fewest side effects. Sham acupuncture may have curative effect except for placebo effect. In the future, it is necessary to perform highly qualified research to prove this result. Pinaverium bromide also has good curative effects with fewer side effects than other drugs.

A Clinical Study published in 2018 in the journal Evidence-Based Complementary and Alternative Medicine found that Drinking alkaline-reduced water can improve the quality of life in patients suffering from diarrhea-predominant irritable bowel syndrome. In this study, twenty-seven patients with diarrhea-predominant irritable bowel syndrome were divided into two groups: one group that drank at least 2 liters of alkaline-reduced water a day, and a control group that drank placebo water. The duration of the experiment was eight weeks, during which symptom scores (including quality of life and abdominal pain/discomfort), stool form, and frequency were evaluated via questionnaires both before and after the treatment duration. The results indicated that an overall greater percentage of patients in the alkaline-reduced water group experienced symptom improvement across the majority of the treatment period compared to the control group. Specifically, the quality of life score in the alkaline-reduced water group significantly improved, a change which was significantly more substantial than the minor improvement seen in the control group. The report about abdominal pain also showed its reduction in both groups, but this change did not significantly differ between the two groups.

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