Miscarriage
Also known as: Pregnancy Loss
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Uncovering the pharmacological mechanism of Shou Tai Wan on recurrent spontaneous abortion: A integrated pharmacology strategy-based research
2024 Apr Journal of Ethnopharmacology Yang K, Zeng L, Li Y, Wu L, Xiang W, Wu X, et al.
Shou Tai Wan (STW) was found to regulate PI3K/AKT, MAPK, and FoxO signaling pathways, and in animal experiments with an RSA mouse model, STW reduced embryo absorption rates, balanced Th1/Th2 cytokine expression, and demonstrated immunomodulatory effects by up-regulating the phosphorylation levels of STAT3 and STAT6 proteins and down-regulating STAT1 protein in the STAT signaling pathway. Additionally, STW up-regulated phosphorylation levels of proteins in the MAPK signaling pathway, and increased expression levels of ERK1/2 mRNA and proteins, suggesting potential therapeutic effects in treating RSA through interference with these signaling pathways.
Experimental Study Animal Study Recurrent Spontaneous Abortion Shou Tai Wan
Effects of Acupuncture Combined with Moxibustion on Reproductive and Metabolic Outcomes in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
2022 Mar 31 Evidence-Based Complementary and Alternative Medicine Li P, Peng J, Ding Z, Zhou X, Liang R
Systematic Review Meta-Analysis Moxibustion AcupunctureAmong patients with PCOS, the combined use of acupuncture and moxibustion as a complementary therapy has additional efficacy regarding increased pregnancy and ovulation rates and reduced miscarriage rate.
A Potential Mechanism of Kidney-Tonifying Herbs Treating Unexplained Recurrent Spontaneous Abortion: Clinical Evidence From the Homogeneity of Embryo Implantation and Tumor Invasion
2022 Jan 26 Frontiers in Pharmacology Zhou H, Yang Y, Deng L, Yao Y, Liao X
KTH has great potential for treating URSA. Because the maintenance of pregnancy has a high similarity with tumor invasion, the research relating to tumor mechanisms should also be followed up as it may lead to new ideas and breakthroughs for research into URSA. At the same time, embryonic and decidual cells share a high degree of cellular heterogeneity and spatial structural complexity with tumor cells, and a single cell combined with spatial omics may be the best future approach for validating KTH mechanisms.
Systematic Review Unexplained Recurrent Spontaneous Abortion Kidney-Tonifying Herbs Recurrent Spontaneous Abortion
An Overview of Systematic Reviews of Acupuncture for Infertile Women Undergoing in vitro Fertilization and Embryo Transfer
2021 Apr 20 Frontiers in Public Health Wang X, Wang Y, Wei S, He B, Cao Y, Zhang N, et al.
Systematic Review AcupunctureBased on the current evidence, acupuncture appears to be beneficial to increase the clinical pregnancy rate in women undergoing in vitro fertilization and embryo transfer.
Effectiveness of different acupuncture for infertility: Overview of systematic reviews and network meta-analysis
2020 Dec European Journal of Integrative Medicine Zhang, J., He, Y., Liu, Y., et al.
Systematic Review Meta-Analysis Female FertilityCompared with western medicine, acupuncture significantly increased the pregnancy and ovulation rates, as well as reducing the rate of miscarriages among Chinese women with infertility.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Among patients with PCOS, the combined use of acupuncture and moxibustion as a complementary therapy has additional efficacy regarding increased pregnancy and ovulation rates and reduced miscarriage rate.
2022 Evidence-Based Complementary and Alternative Medicine Effects of Acupuncture Combined with Moxibustion on Reproductive and Metabolic Outcomes in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Li P, Peng J, Ding Z, Zhou X, Liang R
Systematic Review Acupuncture Moxibustion
The systematic review included 25 RCTs assessing the efficacy and safety of acupuncture combined with moxibustion in treating PCOS, and all of them contributed data to the meta-analysis. Evidence of an association between acupuncture and moxibustion therapy and greater increases in the pregnancy rate and ovulation rate and greater reductions in the miscarriage rate and ovarian volume was found. Additionally, patients receiving acupuncture and moxibustion also exhibited greater improvements in some sex hormones (LH level, LH/FSH ratio and total testosterone level) and indicators related to metabolic disorders (fasting insulin level and BMI). Nevertheless, acupoint stimulation therapy had no significant effect on the levels of FSH, DHEAS, or oestradiol.
In this systematic review, the pregnancy rate among patients who received acupuncture combined with moxibustion reached 50.9%. This value represents a substantial increase compared to that of patients who did not receive acupuncture (27.5%), with an RR of 1.81 and a 4.9% additional increase compared with patients receiving acupuncture + active drugs in the PCOSAct trial (46.0%).
Based on the current evidence, acupuncture appears to be beneficial to increase the clinical pregnancy rate in women undergoing in vitro fertilization and embryo transfer.
2021 Frontiers in Public Health An Overview of Systematic Reviews of Acupuncture for Infertile Women Undergoing in vitro Fertilization and Embryo Transfer Wang X, Wang Y, Wei S, He B, Cao Y, Zhang N, et al.
Systematic Review Acupuncture
This study reviews the SRs of acupuncture for infertile women undergoing IVF-ET. Based on the current evidence, acupuncture appears to be beneficial to increase the CPR in women undergoing IVF-ET. However, there are severe heterogeneity and methodological quality defects, which limit the reliability of results. Further, high-quality primary studies are still needed.
Endometriosis and Adenomyosis can have impact on miscarriage risk in pregnancy.
2020 BioMed Research International Miscarriage on Endometriosis and Adenomyosis in Women by Assisted Reproductive Technology or with Spontaneous Conception: A Systematic Review and Meta-Analysis Yangxue Huang, Xianhong Zhao, Yiyuan Chen, Jie Wang, Weilin Zheng, Lixing Cao
Systematic Review Pregnancy
The study analyzed 39 publications involving 697,984 women to assess the impact of endometriosis (EMS) and adenomyosis (AD) on miscarriage risk. Women with EMS showed increased miscarriage risk in spontaneous conception (SC), but similar risk in assisted reproductive technology (ART) compared to tubal infertility. AD was associated with higher miscarriage risk in ART. Sensitivity analyses supported these conclusions. EMS staging did not significantly alter miscarriage risk. Early-stage EMS showed higher early abortion risk. No significant associations were found between EMS and low birthweight, placental abruption, intrauterine growth restriction, or preeclampsia. EMS correlated with higher odds of antepartum hemorrhage, postpartum hemorrhage, preterm birth, placenta praevia, and stillbirth. SUP and DIE were linked to increased miscarriage risk, while OMA showed no significant association. The findings suggest the need for closer monitoring and follow-up for pregnant women with EMS or AD, particularly in early pregnancy. Standardized recording of EMS types, stages, and miscarriage timing is recommended for future studies.
Compared with western medicine, acupuncture significantly increased the pregnancy and ovulation rates, as well as reducing the rate of miscarriages among Chinese women with infertility.
2020 European Journal of Integrative Medicine Effectiveness of different acupuncture for infertility: Overview of systematic reviews and network meta-analysis Zhang, J., He, Y., Liu, Y., et al.
Systematic Review Female Fertility
Twenty-four eligible RCTs (n=2095) were included in this review. The NMA data showed that warm acupuncture had the highest chances of increasing the rate of pregnancy while acupuncture most positively affected the ovulation rate. On the other hand, a combination of acupuncture and moxibustion had the most significant improvement in endometrial thickness and could reduce the rate of pregnancy loss.
Acupuncture treatment is beneficial in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) for improving the clinical pregnancy, implantation, and live birth outcomes.
2018 European Journal of Integrative Medicine Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: An updated systematic review and meta-analysis Zhang X, Lee MS, Smith CA, Robinson N, Zhou Y, Wu Y, et al.
Systematic Review
Statistically significant differences were observed in rates of clinical pregnancy, live birth, and implantation rate between the acupuncture and the control groups. No significant differences were found for biochemical pregnancies, ongoing pregnancies, or miscarriage between the two groups. Adverse events were described in 4 studies.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Effects of Acupuncture Combined with Moxibustion on Reproductive and Metabolic Outcomes in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
2022 Mar 31 Evidence-Based Complementary and Alternative Medicine Li P, Peng J, Ding Z, Zhou X, Liang R
Systematic Review Meta-Analysis Moxibustion AcupunctureAmong patients with PCOS, the combined use of acupuncture and moxibustion as a complementary therapy has additional efficacy regarding increased pregnancy and ovulation rates and reduced miscarriage rate.
A Potential Mechanism of Kidney-Tonifying Herbs Treating Unexplained Recurrent Spontaneous Abortion: Clinical Evidence From the Homogeneity of Embryo Implantation and Tumor Invasion
2022 Jan 26 Frontiers in Pharmacology Zhou H, Yang Y, Deng L, Yao Y, Liao X
KTH has great potential for treating URSA. Because the maintenance of pregnancy has a high similarity with tumor invasion, the research relating to tumor mechanisms should also be followed up as it may lead to new ideas and breakthroughs for research into URSA. At the same time, embryonic and decidual cells share a high degree of cellular heterogeneity and spatial structural complexity with tumor cells, and a single cell combined with spatial omics may be the best future approach for validating KTH mechanisms.
Systematic Review Unexplained Recurrent Spontaneous Abortion Kidney-Tonifying Herbs Recurrent Spontaneous AbortionAn Overview of Systematic Reviews of Acupuncture for Infertile Women Undergoing in vitro Fertilization and Embryo Transfer
2021 Apr 20 Frontiers in Public Health Wang X, Wang Y, Wei S, He B, Cao Y, Zhang N, et al.
Systematic Review AcupunctureBased on the current evidence, acupuncture appears to be beneficial to increase the clinical pregnancy rate in women undergoing in vitro fertilization and embryo transfer.
Effectiveness of different acupuncture for infertility: Overview of systematic reviews and network meta-analysis
2020 Dec European Journal of Integrative Medicine Zhang, J., He, Y., Liu, Y., et al.
Systematic Review Meta-Analysis Female FertilityCompared with western medicine, acupuncture significantly increased the pregnancy and ovulation rates, as well as reducing the rate of miscarriages among Chinese women with infertility.
Miscarriage on Endometriosis and Adenomyosis in Women by Assisted Reproductive Technology or with Spontaneous Conception: A Systematic Review and Meta-Analysis
2020 Dec 8 BioMed Research International Yangxue Huang, Xianhong Zhao, Yiyuan Chen, Jie Wang, Weilin Zheng, Lixing Cao
Systematic Review Meta-Analysis PregnancyEndometriosis and Adenomyosis can have impact on miscarriage risk in pregnancy.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Presentation Slides
Among patients with PCOS, the combined use of acupuncture and moxibustion as a complementary therapy has additional efficacy regarding increased pregnancy and ovulation rates and reduced miscarriage rate.
Based on the current evidence, acupuncture appears to be beneficial to increase the clinical pregnancy rate in women undergoing in vitro fertilization and embryo transfer.
Endometriosis and Adenomyosis can have impact on miscarriage risk in pregnancy.
Compared with western medicine, acupuncture significantly increased the pregnancy and ovulation rates, as well as reducing the rate of miscarriages among Chinese women with infertility.
Acupuncture treatment is beneficial in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) for improving the clinical pregnancy, implantation, and live birth outcomes.
Acupuncture was a feasible intervention and reduced threatened miscarriage symptoms when compared to a touch intervention.
Despite its widespread use during assisted reproductive technology (ART) cycles, acupuncture does not appear to improve live birth or pregnancy rates in couples dealing with subfertility.
The meta-analysis suggests that acupuncture does not provide significant benefits in improving the outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments.
Complementary and alternative medicine (CAM) therapies have the potential to provide supportive care for women presenting with threatened miscarriage.
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