Dang Gui
Also known as: Angelica Sinensis
Recent Insights
The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
Dang Gui Ginkgo Folium Goji Berry
Various traditional Chinese medicine treatment strategies could potentially provide an effective alternative in slowing the progression of Chronic Kidney Disease.
Chronic Kidney Disease Dan Shen Dang Gui
We showed that Angelica sinensis is not that stimulatory in breast cancer both in vitro and in vivo, though Angelica sinensis should still be used with caution in estrogen receptor-positive breast cancer patients.
Dang Gui
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis
2023 Oct Annals of Translational Medicine Wu J, Sun Z, Zhang D, Liu H, Wu J, Zhang S
Network Pharmacology Dang Gui Ginkgo Folium Shu Di Huang Goji Berry Retinitis PigmentosaThe research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
Traditional Chinese Medicine in the Treatment of Chronic Kidney Diseases: Theories, Applications, and Mechanisms
2022 Jul 18 Frontiers in Pharmacology Yunlai Wang, Ye Feng, Manman Li, Mo Yang, Gaoxiang Shi, Zihua Xuan, et al.
Review Article Huang Qi Yi Qi Qing Re Gao Dang Gui Qu Feng Tong Luo Recipe Dan Shen Zhen Wu Decoction San Qi Chronic Kidney Disease Fu LingVarious traditional Chinese medicine treatment strategies could potentially provide an effective alternative in slowing the progression of Chronic Kidney Disease.
Medicine–food herb: Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications
2022 Jan Food & Function Long Y, Li D, Yu S, Shi A, Deng J, Wen J, et al.
The role of dietary supplement components in AS for AD intervention is summarized, including vitamin B12, folic acid, arginine, and oleic acid, which can improve the symptoms of AD. Besides, this review focuses on the safety and toxicity evaluation of AS, which provides a basis for its application. This review will provide further support for the research on AD and the application of medicine–food herb AS in a healthy lifestyle in the future.
Review Article Alzheimer's Disease Dang GuiEthnopharmacological Survey of Traditional Chinese Medicine Pharmacy Prescriptions for Dysmenorrhea
2021 Dec 21 Frontiers in Pharmacology Su KH, Su SY, Ko CY, Cheng YC, Huang SS, Chao J
The study concludes that Angelica sinensis (Dang Gui), Ligusticum chuanxiong Hort (Chuan Qiong), Rehmannia glutinosa Libosch (Di Huang), Paeonia lactiflora Pall (Bai Shao), Hedysarum polybotrys Hand.-Mazz (Hong Qi), Lycium chinense Mill (Gou Qi Zi), and Cinnamomum cassia (Gui Zhi) are the seven core medicinal materials frequently used in TCM prescriptions for dysmenorrhea, forming 58 combinations with 107 association rules. The study emphasizes the valuable knowledge on TCM pharmacy prescriptions for dysmenorrhea and suggests potential avenues for future pharmacological research and the development of naturally derived medications.
Network Pharmacology Period Pain
Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke
2021 Sep Phytomedicine Han Y, Chen Y, Zhang Q, Liu BW, Yang L, Xu YH, et al.
A. sinensis is a key agent for ischemic stroke treatment, and worth deeply excavating its therapeutic potentiality with the aid of pharmacological network, computer-aided drug design, artificial intelligence, big data and multi-scale modelling techniques.
Systematic Review Stroke Dang GuiResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
2023 Annals of Translational Medicine Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis Wu J, Sun Z, Zhang D, Liu H, Wu J, Zhang S
Network Pharmacology Ginkgo Folium Goji Berry Retinitis Pigmentosa
The research used various databases such as Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, GeneCards, and the Online Mendelian Inheritance in Man database to gather the ingredients of RALRG and potential targets of RP and RALRG. A protein-protein interaction network was constructed to visualize these interactions. The R program was utilized to perform functional enrichment. The researchers constructed a visual RALRG-RP-pathway pharmacology network using Cytoscape 3.9.1 and applied molecular docking to compute binding affinity.
The research revealed a total of 132 effective active elements in RALRG correlating to 248 target genes. Ninety-two intersection target genes were discovered from the overlap of RP- and RALRG-related genes. These intersection targets were discovered to be primarily involved in oxidative stress, responding to metal ions, and handling chemical stress. Several molecular pathways such as PI3K-AKT and MAPK were identified as closely connected to RP therapy. A potential pharmacology network was designed for the RALRG-RP-pathway with AKT1 and JUN being considered the main targets. The active ingredients luteolin, quercetin, and kaempferol were highlighted as crucial for this mechanism. RALRG overall was established as a main regulator for oxidative stress and PI3K/AKT signaling pathways in the treatment of RP.
Various traditional Chinese medicine treatment strategies could potentially provide an effective alternative in slowing the progression of Chronic Kidney Disease.
2022 Frontiers in Pharmacology Traditional Chinese Medicine in the Treatment of Chronic Kidney Diseases: Theories, Applications, and Mechanisms Yunlai Wang, Ye Feng, Manman Li, Mo Yang, Gaoxiang Shi, Zihua Xuan, et al.
Review Article Chronic Kidney Disease Dan Shen Fu Ling
The study explores the use of Traditional Chinese Medicine (TCM) and various Chinese materia medica (CMM) to manage Chronic Kidney Disease (CKD). The review delves deeper into the principles and treatment approaches of TCM in battling CKD, dictating that the disease's nature is deficient in the root and excessive in the branches, where deficiency and excess persist simultaneously throughout the condition. The main strategies employed by TCM in the treatment of CKD include invigorating Qi, tonifying kidneys, promoting blood circulation, removing stasis, eliminating heat and dampness, reducing turbidity, and controlling edema.
The discussion highlights the effectiveness of several CMMs in treating CKD, which are undergirded by clinical evidence or experimental studies. Notably, it points out a correlation between the macroscopic view of TCM and the microscopic view of modern medicine. These TCM and CMM strategies are hailed for their multi-targeted and multi-functional characteristics, potentially providing an effective alternative treatment approach for CKD.
We showed that Angelica sinensis is not that stimulatory in breast cancer both in vitro and in vivo, though Angelica sinensis should still be used with caution in estrogen receptor-positive breast cancer patients.
2019 Frontiers in Pharmacology Is Danggui Safe to be Taken by Breast Cancer Patients?-A Skepticism Finally Answered by Comprehensive Preclinical Evidence Yue Grace Gar-Lee, Wong Lok-Sze, Leung Hoi-Wing, Gao Si, Tsang Julia Yuen-Shan, Lin Zhi-Xiu, et al.
The present findings provided further scientific evidences, which showed that the estrogenic herb AS are not that stimulatory in breast cancer both in vitro and in vivo, though it should still be used with caution particularly in ER-positive breast cancer patients. This is the first systematic pre-clinical study to illustrate the safety use of AS in breast cancer patients by providing varied levels of evidences.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Traditional Chinese Medicine in the Treatment of Chronic Kidney Diseases: Theories, Applications, and Mechanisms
2022 Jul 18 Frontiers in Pharmacology Yunlai Wang, Ye Feng, Manman Li, Mo Yang, Gaoxiang Shi, Zihua Xuan, et al.
Review Article Huang Qi Yi Qi Qing Re Gao Dang Gui Qu Feng Tong Luo Recipe Dan Shen Zhen Wu Decoction San Qi Chronic Kidney Disease Fu LingVarious traditional Chinese medicine treatment strategies could potentially provide an effective alternative in slowing the progression of Chronic Kidney Disease.
Medicine–food herb: Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications
2022 Jan Food & Function Long Y, Li D, Yu S, Shi A, Deng J, Wen J, et al.
The role of dietary supplement components in AS for AD intervention is summarized, including vitamin B12, folic acid, arginine, and oleic acid, which can improve the symptoms of AD. Besides, this review focuses on the safety and toxicity evaluation of AS, which provides a basis for its application. This review will provide further support for the research on AD and the application of medicine–food herb AS in a healthy lifestyle in the future.
Review Article Alzheimer's Disease Dang GuiOverview of therapeutic potentiality of Angelica sinensis for ischemic stroke
2021 Sep Phytomedicine Han Y, Chen Y, Zhang Q, Liu BW, Yang L, Xu YH, et al.
A. sinensis is a key agent for ischemic stroke treatment, and worth deeply excavating its therapeutic potentiality with the aid of pharmacological network, computer-aided drug design, artificial intelligence, big data and multi-scale modelling techniques.
Systematic Review Stroke Dang GuiRadix Astragali and Radix Angelicae Sinensis in the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-analysis
2020 Apr 30 Frontiers in Pharmacology Zhang Y, Gu L, Xia Q, Tian L, Qi J, Cao M
RA and RAS are effective and safe in the treatment of IPF, which is beneficial to pulmonary function and exercise tolerance of these patients.
Systematic Review Meta-Analysis Huang Qi Dang GuiStudy Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
Various traditional Chinese medicine treatment strategies could potentially provide an effective alternative in slowing the progression of Chronic Kidney Disease.
We showed that Angelica sinensis is not that stimulatory in breast cancer both in vitro and in vivo, though Angelica sinensis should still be used with caution in estrogen receptor-positive breast cancer patients.
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