GERD
GERD (Gastroesophageal Reflux Disease) is a chronic condition where stomach acid flows back into the esophagus, causing symptoms such as heartburn and regurgitation.
Also known as: Acid Reflux, Gastroesophageal Reflux Disease, Heartburn
Recent Insights
Bicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life.
GERD Mineral Water
Positive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life.
GERD Indigestion
Patients receiving acupuncture combined with western medicine had a superior global symptom improvement compared with those receiving western medicine alone for gastro-oesophageal reflux disease.
Digestive Health GERD
Hydrogen carbonate-rich mineral water significantly reduces heartburn frequency and severity, improving quality of life with excellent tolerability.
GERD Hydrogen Carbonate Mineral Water
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
How to submit an article:
- Registered users can submit any published journal article that has a unique DOI (Digital Object Identifier) name or link to Research Hub.
- For example, you can paste the full DOI link:
https://doi.org/10.1109/5.771073
or just the DOI name:10.1109/5.771073
into the field above and click submit. - The person who is first to submit a valid article to Research Hub will forever be credited for it, and every article submission earns you +6 Research Points.
Heartburn relief with bicarbonate-rich mineral water: results of the randomised, placebo-controlled phase-III trial STOMACH STILL
2023 Feb BMJ Open Gastroenterology Labenz J, Anschütz M, Walstab J, Wedemeyer RS, Wolters H, Schug B
Randomised Controlled Trial GERD Mineral WaterBicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life.
Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review
2020 May 21 World Journal of Gastroenterology Guo Y, Wei W, Chen JD
GERD IndigestionPositive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life.
Efficacy of Chinese Herbal Formula Sini Zuojin Decoction in Treating Gastroesophageal Reflux Disease: Clinical Evidence and Potential Mechanisms
2020 Feb 27 Frontiers in Pharmacology Li Shaowei, Huang Mengfen, Wu Guojing, Huang Weihan, Huang Zhanhui, Yang Xiaoqian, et al.
Chinese herbal formula Sini Zuojin Decoction (SNZJD) might be useful in the treatment of Gastroesophageal Reflux Disease (GERD).
Systematic Review Si Ni Zuo Jin Decoction GERDAcupuncture for the treatment of gastro-oesophageal reflux disease: a systematic review and meta-analysis
2017 Oct Acupuncture in Medicine Zhu, J., Guo, Y., Liu, S., et al.
Systematic Review Meta-Analysis GERD Digestive HealthPatients receiving acupuncture combined with western medicine had a superior global symptom improvement compared with those receiving western medicine alone for gastro-oesophageal reflux disease.
Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis
2017 Feb 19 Evidence-Based Complementary and Alternative Medicine Yunkai Dai, Yunzhan Zhang, Danyan Li, Jintong Ye, Weijing Chen, Ling Hu
Evidence from this systematic review shows that modified Banxia Xiexin decoction (MBXD) has a positive efficacy in the treatment of gastroesophageal reflux disease (GERD).
Systematic Review Meta-AnalysisResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Bicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life.
2023 BMJ Open Gastroenterology Heartburn relief with bicarbonate-rich mineral water: results of the randomised, placebo-controlled phase-III trial STOMACH STILL Labenz J, Anschütz M, Walstab J, Wedemeyer RS, Wolters H, Schug B
Randomised Controlled Trial Mineral Water
The STOMACH STILL trial, a multicentre, double-blind, randomized, placebo-controlled study, assessed the effectiveness of Staatl. Fachingen STILL mineral water in relieving heartburn. Adult patients with frequent heartburn episodes for at least six months, but without severe reflux oesophagitis, were recruited. They consumed 1.5 liters per day of either the mineral water (verum) or placebo for six weeks. Primary endpoint was a reduction of at least five points in the Reflux Disease Questionnaire score for heartburn. Secondary endpoints included overall symptom reduction, health-related quality of life measures (QOLRAD), rescue medication intake, and safety/tolerability.
Of the 148 patients randomized, 143 completed the trial. The responder rate was significantly higher in the mineral water group (84.72%) compared to the placebo group (63.51%). Significant improvements were observed in the ‘heartburn’ dimension and overall Reflux Disease Questionnaire scores for the mineral water group. Additionally, three out of five Quality of Life in Reflux and Dyspepsia domains showed improvement: ‘food/drink problems,’ ‘emotional distress,’ and ‘vitality.’ The verum group also reported a decrease in rescue medication use. Only three patients experienced treatment-related adverse events. The study concluded that Staatl. Fachingen STILL mineral water is superior to placebo in relieving heartburn and enhancing health-related quality of life.
Positive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life.
2020 World Journal of Gastroenterology Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review Guo Y, Wei W, Chen JD
Indigestion
In this systematic review, we pooled randomized controlled trials with mechanistic investigations of acupuncture or electroacupuncture in improving dyspeptic symptoms, and illustrated the existing results that may provide potential explanations for the therapeutic effects. The findings of included studies in this review suggest that acupuncture and electroacupuncture can improve gastric motility and accommodation, regulate gastrointestinal hormones and mental status, and alter certain central and autonomic functions in patients with functional dyspepsia. However, due to limitations in the included articles, high-quality studies with well-planned designs and multiregional investigations are necessary to provide more convincing and credible evidence.
Patients receiving acupuncture combined with western medicine had a superior global symptom improvement compared with those receiving western medicine alone for gastro-oesophageal reflux disease.
2017 Acupuncture in Medicine Acupuncture for the treatment of gastro-oesophageal reflux disease: a systematic review and meta-analysis Zhu, J., Guo, Y., Liu, S., et al.
Systematic Review Digestive Health
A total of 12 trials involving 1235 patients were included. Meta-analyses demonstrated that patients receiving MA/EA combined with WM had a superior global symptom improvement compared with those receiving WM alone with no significant heterogeneity. Recurrence rates of those receiving MA/EA alone were lower than those receiving WM with low heterogeneity, while global symptom improvement (six studies) and symptom scores (three studies) were similar. Descriptive analyses suggested that acupuncture also improves quality of life in patients with GORD.
Hydrogen carbonate-rich mineral water significantly reduces heartburn frequency and severity, improving quality of life with excellent tolerability.
2016 World Journal of Gastrointestinal Pathophysiology Efficacy and tolerability of hydrogen carbonate-rich water for heartburn Beer AM
Clinical Study Hydrogen Carbonate Mineral Water
This open, single-center, single-arm clinical pilot study involved 50 patients aged 18-64, suffering from heartburn at least twice weekly for over three months. Excluding those with severe diseases or on heartburn medication, participants drank 1.5 liters of hydrogen carbonate-rich mineral water daily for six weeks, with 300 ml consumed at each meal. The study included five visits for monitoring. Efficacy was assessed through patient self-assessments in a heartburn diary, symptom-specific questionnaires (Reflux Disease Questionnaire, Quality of Life in Reflux and Dyspepsia, Gastrointestinal Quality of Life Index), and overall health-related quality of life using the SF-12. Efficacy and safety were evaluated using the Wilcoxon test, χ2 test, and U-test, considering changes in symptoms and vital signs.
The study reported significant reductions in heartburn occurrences at week 6 in both the intention-to-treat and per-protocol populations. The average weekly heartburn episodes decreased by 5.1, and the duration of symptoms reduced by 19 minutes. Symptom frequency decreased in 89.6% of patients, and symptom duration in 79.2%. There were improvements in all dimensions of the RDQ and disease-specific quality of life. Both patients and investigators rated the water’s efficacy positively, with no serious adverse events reported. Additionally, a slight but significant decrease in both systolic and diastolic blood pressure was observed. The study concluded that hydrogen carbonate-rich mineral water is effective and well-tolerated in alleviating heartburn, enhancing quality of life.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Efficacy of Chinese Herbal Formula Sini Zuojin Decoction in Treating Gastroesophageal Reflux Disease: Clinical Evidence and Potential Mechanisms
2020 Feb 27 Frontiers in Pharmacology Li Shaowei, Huang Mengfen, Wu Guojing, Huang Weihan, Huang Zhanhui, Yang Xiaoqian, et al.
Chinese herbal formula Sini Zuojin Decoction (SNZJD) might be useful in the treatment of Gastroesophageal Reflux Disease (GERD).
Systematic Review Si Ni Zuo Jin Decoction GERDAcupuncture for the treatment of gastro-oesophageal reflux disease: a systematic review and meta-analysis
2017 Oct Acupuncture in Medicine Zhu, J., Guo, Y., Liu, S., et al.
Systematic Review Meta-Analysis GERD Digestive HealthPatients receiving acupuncture combined with western medicine had a superior global symptom improvement compared with those receiving western medicine alone for gastro-oesophageal reflux disease.
Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis
2017 Feb 19 Evidence-Based Complementary and Alternative Medicine Yunkai Dai, Yunzhan Zhang, Danyan Li, Jintong Ye, Weijing Chen, Ling Hu
Evidence from this systematic review shows that modified Banxia Xiexin decoction (MBXD) has a positive efficacy in the treatment of gastroesophageal reflux disease (GERD).
Systematic Review Meta-AnalysisConsistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders
2015 Aug 05 The American Journal of Chinese Medicine Wei Ling, Yi Huang, Jia-Hua Xu, Yang Li, Yan-Mei Huang, Hai-Bing Ling, et al.
Systematic Review Meta-AnalysisClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Heartburn relief with bicarbonate-rich mineral water: results of the randomised, placebo-controlled phase-III trial STOMACH STILL
2023 Feb BMJ Open Gastroenterology Labenz J, Anschütz M, Walstab J, Wedemeyer RS, Wolters H, Schug B
Randomised Controlled Trial GERD Mineral WaterBicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life.
Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders
2015 Jan The American Journal of Chinese Medicine Ling W, Huang Y, Xu JH, Li Y, Huang YM, Ling HB, et al.
The consistent therapeutic efficacy of the single TCM formula on GERD and BRD indirectly indicates reflux as a common pathogenesis in reflux-associated GI disorders.
Randomised Controlled Trial Wen Dan TangStudy Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Randomised Controlled Trial
Bicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life.
Labenz J, Anschütz M, Walstab J, Wedemeyer RS, Wolters H, Schug B
Positive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life.
Guo Y, Wei W, Chen JD
Systematic Review
Patients receiving acupuncture combined with western medicine had a superior global symptom improvement compared with those receiving western medicine alone for gastro-oesophageal reflux disease.
Zhu, J., Guo, Y., Liu, S., Su, X., Li, Y., Yang, Y., Hou, L., Wang, G., Zhang, J., Chen, J. J. D., Wang, Q., Wei, R., & Wei, W.
Clinical Study
Hydrogen carbonate-rich mineral water significantly reduces heartburn frequency and severity, improving quality of life with excellent tolerability.
Beer AM
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for GERD" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for GERD" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for GERD" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Randomised Controlled Trial published in 2023 in the journal BMJ Open Gastroenterology found that Bicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life. The STOMACH STILL trial, a multicentre, double-blind, randomized, placebo-controlled study, assessed the effectiveness of Staatl. Fachingen STILL mineral water in relieving heartburn. Adult patients with frequent heartburn episodes for at least six months, but without severe reflux oesophagitis, were recruited. They consumed 1.5 liters per day of either the mineral water (verum) or placebo for six weeks. Primary endpoint was a reduction of at least five points in the Reflux Disease Questionnaire score for heartburn. Secondary endpoints included overall symptom reduction, health-related quality of life measures (QOLRAD), rescue medication intake, and safety/tolerability. Of the 148 patients randomized, 143 completed the trial. The responder rate was significantly higher in the mineral water group (84.72%) compared to the placebo group (63.51%). Significant improvements were observed in the ‘heartburn’ dimension and overall Reflux Disease Questionnaire scores for the mineral water group. Additionally, three out of five Quality of Life in Reflux and Dyspepsia domains showed improvement: ‘food/drink problems,’ ‘emotional distress,’ and ‘vitality.’ The verum group also reported a decrease in rescue medication use. Only three patients experienced treatment-related adverse events. The study concluded that Staatl. Fachingen STILL mineral water is superior to placebo in relieving heartburn and enhancing health-related quality of life.
A published in 2020 in the journal World Journal of Gastroenterology found that Positive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life. In this systematic review, we pooled randomized controlled trials with mechanistic investigations of acupuncture or electroacupuncture in improving dyspeptic symptoms, and illustrated the existing results that may provide potential explanations for the therapeutic effects. The findings of included studies in this review suggest that acupuncture and electroacupuncture can improve gastric motility and accommodation, regulate gastrointestinal hormones and mental status, and alter certain central and autonomic functions in patients with functional dyspepsia. However, due to limitations in the included articles, high-quality studies with well-planned designs and multiregional investigations are necessary to provide more convincing and credible evidence.
A Systematic Review published in 2017 in the journal Acupuncture in Medicine found that Patients receiving acupuncture combined with western medicine had a superior global symptom improvement compared with those receiving western medicine alone for gastro-oesophageal reflux disease. A total of 12 trials involving 1235 patients were included. Meta-analyses demonstrated that patients receiving MA/EA combined with WM had a superior global symptom improvement compared with those receiving WM alone with no significant heterogeneity. Recurrence rates of those receiving MA/EA alone were lower than those receiving WM with low heterogeneity, while global symptom improvement (six studies) and symptom scores (three studies) were similar. Descriptive analyses suggested that acupuncture also improves quality of life in patients with GORD.
A Clinical Study published in 2016 in the journal World Journal of Gastrointestinal Pathophysiology found that Hydrogen carbonate-rich mineral water significantly reduces heartburn frequency and severity, improving quality of life with excellent tolerability. This open, single-center, single-arm clinical pilot study involved 50 patients aged 18-64, suffering from heartburn at least twice weekly for over three months. Excluding those with severe diseases or on heartburn medication, participants drank 1.5 liters of hydrogen carbonate-rich mineral water daily for six weeks, with 300 ml consumed at each meal. The study included five visits for monitoring. Efficacy was assessed through patient self-assessments in a heartburn diary, symptom-specific questionnaires (Reflux Disease Questionnaire, Quality of Life in Reflux and Dyspepsia, Gastrointestinal Quality of Life Index), and overall health-related quality of life using the SF-12. Efficacy and safety were evaluated using the Wilcoxon test, χ2 test, and U-test, considering changes in symptoms and vital signs. The study reported significant reductions in heartburn occurrences at week 6 in both the intention-to-treat and per-protocol populations. The average weekly heartburn episodes decreased by 5.1, and the duration of symptoms reduced by 19 minutes. Symptom frequency decreased in 89.6% of patients, and symptom duration in 79.2%. There were improvements in all dimensions of the RDQ and disease-specific quality of life. Both patients and investigators rated the water’s efficacy positively, with no serious adverse events reported. Additionally, a slight but significant decrease in both systolic and diastolic blood pressure was observed. The study concluded that hydrogen carbonate-rich mineral water is effective and well-tolerated in alleviating heartburn, enhancing quality of life.
Moderation Tools
Topic
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.
No access to full-text —Rachael L 8 Apr 2022