Dry Eye

Presentation Slides

Chinese Medicine Research Hub

Network Pharmacology

Chrysanthemum has several active ingredients that can potentially treat dry eye by inhibiting inflammation-related factors and pathways, thus reducing inflammation of lacrimal gland tissue.

2023 TMR Pharmacology Research A network pharmacology-based investigation of the mechanism of action of chrysanthemum in treating dry eye
Cao LY, Long Q, Jiang PF, Peng J, Peng QH

Chinese Medicine Research Hub

Traditional Chinese medicine (TCM) can effectively treat dry eye disease (DED), and combining TCM with Western medicine can significantly enhance therapeutic effects and reduce treatment costs.

2021 Tzu Chi Medical Journal Retrospective evaluation of the curative effect of traditional Chinese medicine on dry eye disease
Yang CC, Su SH, Ho TJ

Chinese Medicine Research Hub

Randomised Controlled Trial

A botanical formula of lutein ester, zeaxanthin, and extracts from blackcurrant, chrysanthemum, and goji berry can effectively lessen eye fatigue and improve macular function.

2020 The American Journal of Clinical Nutrition A novel botanical formula improves eye fatigue and dry eye: a randomized, double-blind, placebo-controlled study
Kan J, Wang M, Liu Y, Liu H, Chen L, Zhang X, Huang C, Liu BY, Gu Z, Du J

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Dry Eye" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Dry Eye" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Dry Eye" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Network Pharmacology published in 2023 in the journal TMR Pharmacology Research found that Chrysanthemum has several active ingredients that can potentially treat dry eye by inhibiting inflammation-related factors and pathways, thus reducing inflammation of lacrimal gland tissue. The study used network pharmacology methods and various databases to further analyze the mechanism of Chrysanthemum in treating dry eye. First, the TCMSP was used to screen for candidate active ingredient molecules of chrysanthemum showcasing requisite oral bioavailability and drug similarity. The active ingredients of chrysanthemum were then identified, followed by target prediction. Cytoscape was used to construct a compound-target network for chrysanthemum. The Online Mendelian Inheritance in Man and DisGeNET databases were utilized to pinpoint pathogenic genes associated with dry eye, and the STRING database produced an interaction network and bar graph to scrutinize protein interactions. Using Venny, a final drug-active ingredient-key target-disease network was created. The study found that Chrysanthemum has eighty active ingredients corresponding to targets for treating dry eye. These key functional targets primarily regulate gene expression, oxidative stress, immune response, apoptosis, proliferation, regulation of cellular inflammation-related factors, and angiogenesis. The primary pathways associated with these key targets include interleukin signaling, metabolism, cytokine signaling in the immune system, immune system, and signal transduction, thereby improving the condition of dry eye primarily through the inhibition of inflammation-related factors.

A published in 2021 in the journal Tzu Chi Medical Journal found that Traditional Chinese medicine (TCM) can effectively treat dry eye disease (DED), and combining TCM with Western medicine can significantly enhance therapeutic effects and reduce treatment costs. The researchers carried out a comprehensive review of studies conducted from 2001 to 2020, focusing on the use of Traditional Chinese Medicine (TCM) and an integration of Chinese and Western medicine for the treatment of DED. Four categories of Chinese medicines were identified for their application in treating DED: anti-oxidants, anti-inflammatory agents, hormone-like agents, and cell-repairing agents. In addition, they also acknowledged the usage of compound herbs like Chi-Ju-Di-Huang-Wan and Qiming granule for alleviating dry eye symptoms. The researchers arrived at significant findings from their examination of multiple studies. The use of Traditional Chinese Medicine (TCM) has shown effective results in the treatment of Dry Eye Disease (DED). Moreover, the integration of TCM with Western medicine has amplified the therapeutic effects in patients while making the treatment cost-effective. This suggests that not only can TCM be a promising approach for treating DED, but a combined treatment strategy with Western medicine can also lead to substantial improvements in curing the condition.

A Randomised Controlled Trial published in 2020 in the journal The American Journal of Clinical Nutrition found that A botanical formula of lutein ester, zeaxanthin, and extracts from blackcurrant, chrysanthemum, and goji berry can effectively lessen eye fatigue and improve macular function. Research methodology involved the distribution of 360 randomly selected participants into four groups where they received placebos and three varied doses of a botanical formula. This formula, given in chewable tablets comprised of 6 mg, 10 mg, or 14 mg of lutein. Each participant was administered these once daily over a period of 90 days, and had three check-ins at the beginning, at day 45, and finally on day 90 of the study. The results of the study indicated that the botanical formula effectively improved the individual scores of participants on eye fatigue symptoms like eye soreness, blurred vision, dry eyes, foreign body sensation, and tearing. Using the formula resulted in a notable decrease in the total score of eye fatigue symptoms at both the 45-day and 90-day intervals as compared to the placebo while also significantly improving visuognosis persistence time. Tear secretion improvement was observed in the groups having 10mg and 14mg lutein formula, supported by the Schirmer test. Furthermore, the results showed an increase in macular pigment optical density with all three doses of the formula, but no significant alterations were observed in the retinal thickness and retinal volume among all the groups at both check-ins.

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