Snow Fungus

Presentation Slides

Chinese Medicine Research Hub

Randomised Controlled Trial

A beverage formula containing fish roe, snow fungus, and yeast enhances cognitive function by improving memory, response times, and emotional recognition, while reducing anxiety and fatigue.

2023 Nutrients Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Lin YK, Lin YH, Chiang CF, Jingling L

Chinese Medicine Research Hub

Experimental Study

Tremella fuciformis polysaccharides effectively reduce inflammation in ulcerative colitis, promoting healing by restoring intestinal and mucus barrier functions.

2021 International Journal of Biological Macromolecules Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function
Xu Y, Xie L, Zhang Z, et al

Chinese Medicine Research Hub

Systematic Review

Tremella polysaccharide is a safe natural active ingredient, which can be used in the prevention, treatment and rehabilitation of diseases.

2021 International Journal of Immunopathology and Pharmacology A review on the production, structure, bioactivities and applications of Tremella polysaccharides
Ma, X., Yang, M., He, Y., Zhai, C., & Li, C.

Chinese Medicine Research Hub

Systematic Review

These results indicate that a certain concentration of snow fungus polysaccharides can effectively alleviate skin damage caused by UVA, and they may be used as an effective component of cosmetics.

2021 Journal of Cosmetic Dermatology Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways
Fu H, You S, Zhao D, An Q, Zhang J, Wang C, Wang D, Li M.

Chinese Medicine Research Hub

Systematic Review

Tremella fuciformis polysaccharide alleviated hydrogen peroxide‑induced oxidative stress and apoptosis in skin fibroblasts via upregulation of SIRT1 expression, indicating that TFPS may act as a potential therapeutic agent for oxidative‑stress‑associated skin diseases and aging.

2017 Molecular Medicine Reports Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1
Shen T, Duan C, Chen B, Li M, Ruan Y, Xu D, Shi D, Yu D, Li J, Wang C.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Snow Fungus" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Snow Fungus" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Snow Fungus" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Randomised Controlled Trial published in 2023 in the journal Nutrients found that A beverage formula containing fish roe, snow fungus, and yeast enhances cognitive function by improving memory, response times, and emotional recognition, while reducing anxiety and fatigue. In the study, 64 volunteers were divided into two equal groups, with one group consuming a placebo and the other consuming the formula beverage for a duration of 8 weeks. Cognitive testing was performed initially and at two follow-up points, weeks 4 and 8. Variables tested included memory recall, identification of objects over time, response times, emotional recognition from facial expressions and self-reported anxiety and fatigue levels. The results demonstrated that by weeks 4 and 8, those who consumed the formula beverage showed notable advancements in cognitive functions. These individuals were able to remember objects better and had quicker response times. Notably, they also registered a significant improvement in recognizing happy faces and displayed reduced anxiety and fatigue. Overall, the beverage holds promise as an intervention tool for cognitive improvement in individuals reporting subjective cognitive issues.

A Experimental Study published in 2021 in the journal International Journal of Biological Macromolecules found that Tremella fuciformis polysaccharides effectively reduce inflammation in ulcerative colitis, promoting healing by restoring intestinal and mucus barrier functions. In this study, two models were utilized to investigate the impacts of Tremella fuciformis polysaccharides on ulcerative colitis: a dextran sodium sulfate-induced mice model and a lipopolysaccharide-stimulated model using Caco-2 cells. First, the dextran sodium sulfate-induced mice ulcerative colitis model was administered with the Tremella fuciformis polysaccharides. Effects were observed across several indicators such as body weight, colon length, and thickness, as well as intestinal permeability. Following that, histopathological analysis and electron microscope examinations helped delve deeper into the relationship, uncovering a reduction in inflammatory cell infiltration and a restoration of the intestinal epithelial barrier integrity. The lipopolysaccharide-stimulated Caco-2 cells model was used to further understand the role of these polysaccharides in reducing expressions of pro-inflammatory cytokines and increasing expressions related to intestinal barrier and mucus barrier.

A Systematic Review published in 2021 in the journal International Journal of Immunopathology and Pharmacology found that Tremella polysaccharide is a safe natural active ingredient, which can be used in the prevention, treatment and rehabilitation of diseases. Tremella polysaccharide is a full-functioning active substance, and any of its activities are not independent, but complementary to other activities. For example, Tremella polysaccharides can participate in various physiological activities such as type II diabetes, cardiovascular disease, metabolic syndrome, inflammation and aging by regulating the expression of SIRT1 protein, which is in line with the guidelines of eastern medicine to maintain the dynamic balance of the human body through conditioning. Tremella polysaccharides are non-toxic and harmless natural ingredients that can be used for long-term contact with the human body by smearing or oral administration. It means that Tremella polysaccharides are suitable for the daily health needs of sub-healthy people and can be widely used in food, medicine and daily chemical products.

A Systematic Review published in 2021 in the journal Journal of Cosmetic Dermatology found that These results indicate that a certain concentration of snow fungus polysaccharides can effectively alleviate skin damage caused by UVA, and they may be used as an effective component of cosmetics. Tremella fuciformis polysaccharides (TFPS) pretreatment can reduce the oxidative stress of UVA-treated human dermal fibroblasts cells. After TFPS pretreatment, the content of ROS and MDA in the cell decreased significantly and the total antioxidant activity was increased. Among them, the active of CAT, SOD, and GSH-Px in the cells increased significantly. TFPS can also protect fibroblasts by up-regulating Nrf2 and down-regulating Keap1 expression. Finally, it was also found that TFPS pretreatment increased the content of collagen I, elastin, and hyaluronic acid (HA) in skin fibroblasts treated with UVA.

A Systematic Review published in 2017 in the journal Molecular Medicine Reports found that Tremella fuciformis polysaccharide alleviated hydrogen peroxide‑induced oxidative stress and apoptosis in skin fibroblasts via upregulation of SIRT1 expression, indicating that TFPS may act as a potential therapeutic agent for oxidative‑stress‑associated skin diseases and aging. We demonstrated that pretreatment with TFPS suppressed H2O2-induced oxidative stress and apoptosis in skin fibroblasts in a concentration-dependent manner and possessed excellent antioxidative properties. Therefore, our present findings may provide a theoretical basis for TFPS as an alternative herbal food supplement and potential pharmacotherapy for skin injury and aging. However, given that TFPS contains several polysaccharides and has a variety of pharmacological effects, our study, which focused on oxidative stress inhibition and anti-apoptotic effects, has limitations. Further studies are required to define the potential protective mechanisms of TFPS in H2O2-induced skin injury. In summary, we revealed that TFPS exhibits protective properties against hydrogen peroxide-induced oxidative stress and apoptosis mainly by upregulating SIRT1 and promoting downstream signaling, suggesting that TFPS is a potential therapeutic agent for oxidative stress-related skin diseases and skin aging.

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