Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways

Fu H, You S, Zhao D, An Q, Zhang J, Wang C, Wang D, Li M. · Journal of Cosmetic Dermatology · 2021 March 9

Objective

This study aims to explore the potential protective mechanism of Tremella fuciformis polysaccharides on UVA-induced damage to human dermal fibroblasts cells.

Conclusions

The study highlights the efficacy of snow fungus in alleviating skin damage caused by UVA. Hence it is an effective component of cosmetics in reducing the oxidative stress of UVA

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Insights

These results indicate that a certain concentration of snow fungus polysaccharides can effectively alleviate skin damage caused by UVA, and they may be used as an effective component of cosmetics.

Tremella fuciformis polysaccharides (TFPS) pretreatment can reduce the oxidative stress of UVA-treated human dermal fibroblasts cells. After TFPS pretreatment, the content of ROS and MDA in the cell decreased significantly and the total antioxidant activity was increased. Among them, the active of CAT, SOD, and GSH-Px in the cells increased significantly. TFPS can also protect fibroblasts by up-regulating Nrf2 and down-regulating Keap1 expression. Finally, it was also found that TFPS pretreatment increased the content of collagen I, elastin, and hyaluronic acid (HA) in skin fibroblasts treated with UVA.