Food As Medicine

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Research Articles

Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.

Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis

2024 Nov International Journal of Biological Macromolecules Peng G, Wang S, Zhang H, Xie F, Jiao L, Yuan Y, et al.

Animal Study Gut Microbiota Ulcerative Colitis Intestinal Barrier Snow Fungus

This article was submitted by Jinnan C. and is awaiting moderation..

A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.

Therapeutic Potential of Pomegranate Extract for Women’s Reproductive Health and Breast Cancer

2024 Oct 03 Life Jang JY, Kim D, Im E, Kim ND

PCOS Breast Cancer Pomegranate

This article was submitted by Jinnan C. and is awaiting moderation..

Pomegranate extract could potentially benefit women's reproductive health, enhance fertility, regulate menstrual cycles, support pregnancy, and help treat polycystic ovary syndrome.

Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models

2024 Jul 22 Nutrients Márquez-Garbán DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, et al.

Animal Study Experimental Study Honey Breast Cancer

Manuka honey has demonstrated the potential to inhibit the proliferation of human breast cancer cells and stimulate apoptosis in these cells.

Intake of Blueberries, Anthocyanins, and Risk of Eye Disease in Women

2024 Apr The Journal of Nutrition Sesso HD, Rautiainen S, Park SJ, Kim E, Lee IM, Glynn RJ, et al.

Cohort Study Clinical Study Eye Health Age-Related Macular Degeneration Anthocyanins Blueberry

Greater intake of blueberries considerably decreases the risk of age-related macular degeneration, while a remarkable dietary intake of anthocyanins inversely correlates with cataract incidents.

The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis

2024 Feb 25 Food Science & Nutrition Heydarian A, Tahvilian N, Asbaghi O, Cheshmeh S, Nadery M, Aryaeian N

Systematic Review Cholesterol LDL Plum

Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues.

Research Insights

Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.

A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.

2024 International Journal of Biological Macromolecules Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis Peng G, Wang S, Zhang H, Xie F, Jiao L, Yuan Y, et al.

Animal Study Gut Microbiota Intestinal Barrier Snow Fungus

The methodology used in this research involved isolating TA 2-1, a specific polysaccharide from Tremella Aurantialba, and studying its effects on ulcerative colitis. This was done by introducing it to Caco-2 cells that were undergoing ferroptosis and assessing its impact on cell viability. The influence of TA 2-1 was also examined in mice with artificially induced ulcerative colitis, verifying its ameliorating effects in an in-vivo context. The structure of TA 2-1 and its components were analysed and the polysaccharide's interaction with gut microbiota was explored to understand how it might modulate symptoms or prevent cell death.

The results of this study showed that TA 2-1 does not only decrease the rate of cell death in epithelial cells undergoing ferroptosis, but it also repairs the intestinal barrier by upregulating specific proteins such as claudin-1 and zonula occludens-1. TA 2-1 was also found to suppress lipid peroxidation, thus inhibiting ferroptosis. Further investigation revealed that TA 2-1 may alleviate ulcerative colitis by influencing the composition or metabolites of gut microbiota. This research offers promising insight into the potential of TA 2-1 in treating ulcerative colitis.

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Pomegranate extract could potentially benefit women's reproductive health, enhance fertility, regulate menstrual cycles, support pregnancy, and help treat polycystic ovary syndrome.

2024 Life Therapeutic Potential of Pomegranate Extract for Women’s Reproductive Health and Breast Cancer Jang JY, Kim D, Im E, Kim ND

Breast Cancer PCOS Pomegranate

In establishing the potential benefits of pomegranate extract in women's reproductive health, a wide array of methods was employed. Primarily, these included in vitro studies, animal modeling and certain clinical trials. Analyses of the antioxidant properties of the extract were done to ascertain its effectiveness in reducing oxidative stress and consequently, improving fertility. The influence of pomegranate extract on hormonal imbalances and menstrual regulation was also studied.

Discussions on the results emphasized the potential of pomegranate extract in supporting women's reproductive health. The extract was found beneficial in enhancing fertility, regulating menstruation and supporting pregnancy. Further, it could help in polycystic ovary syndrome therapy by improving insulin sensitivity and reducing oxidative damage. Its rich nutrient composition was appreciated for potentially fostering placental development and fetal growth, thus possibly mitigating the risk of early birth. Apart from reproductive health, some studies pointed towards pomegranate extract's potential anticancer properties, primarily against breast cancer.

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Manuka honey has demonstrated the potential to inhibit the proliferation of human breast cancer cells and stimulate apoptosis in these cells.

2024 Nutrients Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models Márquez-Garbán DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, et al.

Animal Study Breast Cancer Honey

In the experiment, Manuka honey was applied to three different types of cells: MCF-7 human breast cancer cells, MDA-MB-231 breast cancer cells, and non-malignant human mammary epithelial cells. The concentrations applied ranged from 0.3 to 5.0% to observe different effects. In addition to inhibiting cancer cell proliferation, the honey was tested for its ability to cause apoptosis (cell death) among the MCF-7 cells. It was also compared to the effects of tamoxifen, an antiestrogen medication used in breast cancer treatment.

The results showed that Manuka honey was able to significantly inhibit the proliferation of MCF-7 cells, though its effects were less pronounced in the MDA-MB-231 breast cancer cells. The non-malignant cells were not affected. The honey's antitumor activity was comparable to that of tamoxifen. Moreover, Manuka honey stimulated apoptosis in the MCF-7 cells. It was also observed that the honey activated AMPK, which inhibits specific cellular growth signals, and reduced STAT3 levels, a protein often elevated in tumors.

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Greater intake of blueberries considerably decreases the risk of age-related macular degeneration, while a remarkable dietary intake of anthocyanins inversely correlates with cataract incidents.

2024 The Journal of Nutrition Intake of Blueberries, Anthocyanins, and Risk of Eye Disease in Women Sesso HD, Rautiainen S, Park SJ, Kim E, Lee IM, Glynn RJ, et al.

Cohort Study Age-Related Macular Degeneration Anthocyanins Blueberry

Middle-aged and older women, numbering 36,653 and 35,402 originally without cataract and AMD, provided data for the study via semiquantitative food frequency questionnaires. Insights were derived on the consumption of blueberries by these women, with frequency varied from none to over two servings weekly. Additionally, total anthocyanin consumption was analysed, with major subclasses adjusted for energy and then into quintiles. Self-reported risk factors for eye diseases were adjusted in the multivariable hazard ratios.

On analysis, it was found that a significant portion of participants consumed a minimum of one serving of blueberries weekly. Thus, compared to no blueberry intake, it was observed that those consuming the fruit exhibited a decrease in the total instances of AMD, while visually significant AMD remained unaffected. Furthermore, dietary anthocyanin showed a modest yet significant inverse association with cataract occurrences, but no notable correlation with AMD.

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Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues.

2024 Food Science & Nutrition The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis Heydarian A, Tahvilian N, Asbaghi O, Cheshmeh S, Nadery M, Aryaeian N

Systematic Review Cholesterol LDL Plum

The researchers conducted a systematic review and meta-analysis using keyword searches on databases such as PubMed, Scopus, and ISI Web of Science up to a specified date. They were on a mission to find eligible trials that would help ascertain the benefits of plum consumption on adult lipid profiles.

In their observation of the collected data, they concluded that plum, specifically dried plum consumption, had a noteworthy impact on LDL levels, mainly when the subjects were in an unhealthy state. This consumption led to a significant decrease in total cholesterol levels in the unhealthy subjects. Nevertheless, the study couldn't establish major changes in triglycerides and HDL concentrations as a result of the plum consumption.

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Review Articles

Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.

The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis

2024 Feb 25 Food Science & Nutrition Heydarian A, Tahvilian N, Asbaghi O, Cheshmeh S, Nadery M, Aryaeian N

Systematic Review Cholesterol LDL Plum

Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues.

Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies

2024 Jan Phytomedicine Nunes YC, Santos GO, Machado NM, Otoboni AMMB, Laurindo LF, Bishayee A, et al.

Peanuts and their products, containing phytochemicals, can improve metabolic parameters and have the potential to be used as a sustainable and low-cost alternative for the prevention and treatment of MetS and CVD.

Systematic Review Review Article Peanut

A Comprehensive Review on Therapeutic Properties of Lotus Seeds

2024 Jan SSRN Electronic Journal Marik S, Mukherjee (Datta) D, Sengupta S

Lotus seeds have been traditionally used for their therapeutic benefits in treating various diseases, supported by their nutritional components and bioactive properties, making them a valuable functional food.

Review Article Lotus Seed

Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review

2024 Jan 25 Pharmaceuticals Kusuma IY, Perdana MI, Vágvölgyi C, Csupor D, Takó M

Review Article Lemongrass Oil Dandruff Gingivitis Periodontitis Lemongrass

Lemongrass essential oil can effectively treat periodontitis, gingivitis, oral malodour, skin aging, and dandruff, and it is comparable to certain established treatments.

Carrot intake is consistently negatively associated with cancer incidence: A systematic review and meta-analysis of prospective observational studies

2023 Dec 17 Critical Reviews in Food Science and Nutrition Ojobor CC, O’Brien GM, Siervo M, Ogbonnaya C, Brandt K

Meta-Analysis Systematic Review Cancer Carrot

Consuming carrots can significantly decrease the risk of cancer.

Clinical Trials

Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.

A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome. An exploratory analysis

2023 Dec Complementary Therapies in Medicine Kahleova H, Holtz DN, Strom N, La Reau A, Kolipaka S, Schmidt N, et al.

Randomised Controlled Trial Gut Microbiota Plant-Based Diet Hot Flushes Soybean

Changes in gut microbiome associated with a low-fat, vegan diet and cooked soybeans may reduce the frequency and severity of postmenopausal hot flashes.

Effects of an Unripe Avocado Extract on Glycaemic Control in Individuals with Obesity: A Double-Blinded, Parallel, Randomised Clinical Trial

2023 Nov 17 Nutrients Zhao L, Ingram DK, Gumpricht E, De Paoli T, Teong XT, Liu B, et al.

Randomised Controlled Trial Avocado Blood Sugar Glucose

Consumption of unripe avocado extract in the diet may lower postprandial insulin levels in overweight adults with previously elevated insulin levels.

A 4-Week Pecan-Enriched Diet Improves Postprandial Lipid Peroxidation in Aging Adults

2023 Sep 01 Journal of Medicinal Food Cogan B, Pearson RC, Jenkins NT, Paton CM, Cooper JA

Randomised Controlled Trial Postprandial Oxidative Stress Oxidative Stress Pecan

Daily consumption of pecans for a month can help protect against post-meal oxidative stress in aging adults.

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2023 Sep 29 Nutrients Lin YK, Lin YH, Chiang CF, Jingling L

Randomised Controlled Trial Yeast Fish Roe Snow Fungus Cognitive Function

This article was submitted by Jinnan C. and is awaiting moderation..

A beverage formula containing fish roe, snow fungus, and yeast enhances cognitive function by improving memory, response times, and emotional recognition, while reducing anxiety and fatigue.

Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial

2023 Aug The American Journal of Clinical Nutrition Hodges JK, Maiz M, Cao S, Lachcik PJ, Peacock M, McCabe GP, et al.

Experimental Study Clinical Study Randomised Controlled Trial Bone Calcium Blueberry

Moderate consumption of blueberries may effectively reduce bone loss in healthy postmenopausal women.

Study Protocols

Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.

Presentation Slides

Chinese Medicine Research Hub

Journal of Tropical Pharmacy and Chemistry

Animal Study
A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.

2024 International Journal of Biological Macromolecules Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis
Peng G, Wang S, Zhang H, Xie F, Jiao L, Yuan Y, Ma C, Wu H, Meng Z

Chinese Medicine Research Hub

Pomegranate extract could potentially benefit women's reproductive health, enhance fertility, regulate menstrual cycles, support pregnancy, and help treat polycystic ovary syndrome.

2024 Life Therapeutic Potential of Pomegranate Extract for Women’s Reproductive Health and Breast Cancer
Jang JY, Kim D, Im E, Kim ND

Chinese Medicine Research Hub

Animal Study
Manuka honey has demonstrated the potential to inhibit the proliferation of human breast cancer cells and stimulate apoptosis in these cells.

2024 Nutrients Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models
Márquez-Garbán DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, Wadehra M, McCloskey SA, Pietras RJ

Chinese Medicine Research Hub

Cohort Study
Greater intake of blueberries considerably decreases the risk of age-related macular degeneration, while a remarkable dietary intake of anthocyanins inversely correlates with cataract incidents.

2024 The Journal of Nutrition Intake of Blueberries, Anthocyanins, and Risk of Eye Disease in Women
Sesso HD, Rautiainen S, Park SJ, Kim E, Lee IM, Glynn RJ, Buring JE, Christen WG

Chinese Medicine Research Hub

Systematic Review
Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues.

2024 Food Science & Nutrition The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis
Heydarian A, Tahvilian N, Asbaghi O, Cheshmeh S, Nadery M, Aryaeian N

Chinese Medicine Research Hub

Review Article
Lemongrass essential oil can effectively treat periodontitis, gingivitis, oral malodour, skin aging, and dandruff, and it is comparable to certain established treatments.

2024 Pharmaceuticals Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review
Kusuma IY, Perdana MI, Vágvölgyi C, Csupor D, Takó M

Chinese Medicine Research Hub

Data Mining
The traditional Chinese medicine prescription combination of Chrysanthemi Flos, Cassiae Semen, Lycii Fructus, Angelicae Sinensis Radix and Salviae Miltiorrhizae Radix et Rhizoma presents potential for treating retinal diseases.

2024 Traditional Medicine Research Exploring a novel traditional Chinese medicine prescription containing Chrysanthemi Flos for retinal diseases: an integrated strategy of data mining and network pharmacology
Zhang JX, Zhang KL, Chang XW, Gu JF, Wei SB, Zhu BY, Wang Q, Wu DL, Gui SY, Yan H, Duan JA

Chinese Medicine Research Hub

Meta-Analysis
Consuming carrots can significantly decrease the risk of cancer.

2023 Critical Reviews in Food Science and Nutrition Carrot intake is consistently negatively associated with cancer incidence: A systematic review and meta-analysis of prospective observational studies
Ojobor CC, O’Brien GM, Siervo M, Ogbonnaya C, Brandt K

Chinese Medicine Research Hub

Systematic Review
Pomegranate fruit and its phytochemicals may offer a novel, natural alternative for the treatment of pathological anxiety, with fewer adverse effects than traditional medications.

2023 Brain Research Pomegranate (Punica granatum L.) and its phytochemicals as anxiolytic; an underreported effect with therapeutic potential: A systematic review
Flores-Bazán T, Betanzos-Cabrera G, Guerrero-Solano JA, Negrete-Díaz JV, German-Ponciano LJ, Olivo-Ramírez D

Chinese Medicine Research Hub

Randomised Controlled Trial
Changes in gut microbiome associated with a low-fat, vegan diet and cooked soybeans may reduce the frequency and severity of postmenopausal hot flashes.

2023 Complementary Therapies in Medicine A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome. An exploratory analysis
Kahleova H, Holtz DN, Strom N, La Reau A, Kolipaka S, Schmidt N, Hata E, Znayenko-Miller T, Holubkov R, Barnard ND

Chinese Medicine Research Hub

Experimental Study
The compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside from chrysanthemum flowers demonstrated superior antioxidant and anti-osteoporosis effects.

2023 Journal of Science and Technology - HaUI Investigate the antioxidant and anti-osteoporosis activities of compounds isolated from chrysanthemum indicum flowers
Le The Hoai, Nguyen Thi Huong, Bui Thi Thu Trang

Chinese Medicine Research Hub

Randomised Controlled Trial
Consumption of unripe avocado extract in the diet may lower postprandial insulin levels in overweight adults with previously elevated insulin levels.

2023 Nutrients Effects of an Unripe Avocado Extract on Glycaemic Control in Individuals with Obesity: A Double-Blinded, Parallel, Randomised Clinical Trial
Zhao L, Ingram DK, Gumpricht E, De Paoli T, Teong XT, Liu B, Mori TA, Heilbronn LK, Roth GS

Chinese Medicine Research Hub

Systematic Review
Pomegranate can significantly enhance women's health during and after menopause by reducing hot flashes severity and other menopause symptoms.

2023 Phytotherapy Research Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis
Moeini R, Shirafkan H, Gorji N

Chinese Medicine Research Hub

Review Article
Almond consumption has beneficial impacts on cardiovascular diseases, diabetes, obesity, and it can improve cognitive performance and protect against skin aging.

2023 Nutrire Nutritional and health-beneficial values of almond nuts consumption
Ouzir M

Chinese Medicine Research Hub

Review Article
Fruits, especially kiwifruits, and rye bread can enhance bowel movements and help manage chronic constipation better than conventional dietary methods.

2023 Alimentary Pharmacology & Therapeutics Systematic review and meta‐analysis: Foods, drinks and diets and their effect on chronic constipation in adults
Van Der Schoot A, Katsirma Z, Whelan K, Dimidi E

Chinese Medicine Research Hub

Cohort Study
Long-term consumption of green tea can potentially lessen the risk of depression in postmenopausal women by decreasing inflammation and boosting estradiol levels.

2023 Nutrients Long-Term Consumption of Green Tea Can Reduce the Degree of Depression in Postmenopausal Women by Increasing Estradiol
Wan Z, Qin X, Tian Y, Ouyang F, Wang G, Wan Q

Chinese Medicine Research Hub

Clinical Study
Consuming bicarbonate-calcium mineral water, low in sodium, can help manage calcium imbalance and support bone health in perimenopausal women.

2023 Metabolites Supplementing Low-Sodium Bicarbonate–Calcic (Lete)® Water: Effects in Women on Bone and Systemic Metabolism
Marino C, Pagano I, Castaldo G, Grimaldi M, D’Elia M, Santoro A, Conte A, Molettieri P, Parisella C, Buonocore M, D’Ursi AM, Rastrelli L

Chinese Medicine Research Hub

Animal Study
A combination of soybean germ extract and a probiotic significantly improved menopause-related conditions and mood in an ovariectomized rat model.

2023 Nutrients Anti-Menopausal Effect of Soybean Germ Extract and Lactobacillus gasseri in the Ovariectomized Rat Model
Lee SH, Lim TJ, Yun EJ, Kim KH, Lim S

Chinese Medicine Research Hub

Experimental Study
Phenolic extracts from turmeric and ginger have significant anti-inflammatory effects and enhance wound healing in Wistar rats.

2023 Cosmetics Effect of Phenolic Compounds Extracted from Turmeric (Curcuma longa L.) and Ginger (Zingiber officinale) on Cutaneous Wound Healing in Wistar Rats
Bouchama C, Zinedine A, Rocha JM, Chadli N, El Ghadraoui L, Chabir R, Raoui SM, Errachidi F

Chinese Medicine Research Hub

Network Pharmacology
The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.

2023 Annals of Translational Medicine Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis
Wu J, Sun Z, Zhang D, Liu H, Wu J, Zhang S

Chinese Medicine Research Hub

Cohort Study
Avocado consumption is linked to better glucose regulation, with metabolomic biomarkers of avocado intake showing even stronger associations with lower glycemia.

2023 The Journal of Nutrition Associations between Metabolomic Biomarkers of Avocado Intake and Glycemia in the Multi-Ethnic Study of Atherosclerosis
Wood AC, Goodarzi MO, Senn MK, Gadgil MD, Graca G, Allison MA, Tzoulaki I, Mi MY, Greenland P, Ebbels T, Elliott P, Tracy RP, Herrington DM, Rotter JI

Chinese Medicine Research Hub

Review Article
Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.

2023 Food Chemistry Advances The whole pomegranate (Punica granatum. L), biological properties and important findings: A review
Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, Zugasti-Cruz A, Ascacio-Valdés JA

Chinese Medicine Research Hub

Randomised Controlled Trial
A beverage formula containing fish roe, snow fungus, and yeast enhances cognitive function by improving memory, response times, and emotional recognition, while reducing anxiety and fatigue.

2023 Nutrients Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Lin YK, Lin YH, Chiang CF, Jingling L

Chinese Medicine Research Hub

Randomised Controlled Trial
Daily consumption of pecans for a month can help protect against post-meal oxidative stress in aging adults.

2023 Journal of Medicinal Food A 4-Week Pecan-Enriched Diet Improves Postprandial Lipid Peroxidation in Aging Adults
Cogan B, Pearson RC, Jenkins NT, Paton CM, Cooper JA

Chinese Medicine Research Hub

Experimental Study
Lycium barbarum polysaccharide may decrease apoptosis in retinal photoreceptor cells of retinitis pigmentosa mice by suppressing nuclear factor-kappa B/NOD-like receptor thermal protein domain-associated protein 3 pathway.

2023 Digital Chinese Medicine Inhibition of photoreceptor apoptosis in mice with retinitis pigmentosa through NF-κB/NLRP3 pathway suppression with Lycium barbarum polysaccharide
Wang Y, Deng Y, Lu J, Peng J, Zhou Y, Yang Y, Peng Q

Chinese Medicine Research Hub

Animal Study
Fermented Pueraria lobata root extract and Glycine max extract showed estrogen-like activities, reducing depressive symptoms in menopausal mice but not increasing female cancer risks.

2023 Journal of Functional Foods Effects of Pueraria lobata root and Glycine max (L.) Merrill extracts fermented with Lactiplantibacillus plantarum on the depressive-like behavior in ovariectomized mice via upregulation of hippocampal BDNF
Ha J, Jang HM, Choi I

Chinese Medicine Research Hub

Review Article
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.

2023 PharmaNutrition Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits
Tan ST, Tan SS, Tan CX

Chinese Medicine Research Hub

Systematic Review
Pomegranate consumption positively affects triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels.

2023 Journal of Functional Foods The effects of pomegranate consumption on lipid profile in adults: A systematic review and meta-analysis
Bahari H, Rezaiian F, Goudarzi K, Nooshan Mirmohammadali S, Asbaghi O, sadat Hosseini kolbadi K, Naderian M, Hosseini A

Chinese Medicine Research Hub

Review Article
Soybean intake can potentially reduce risks of several cancers, type 2 diabetes, osteoporosis, and hot flashes, and it may negatively impact some drug treatments and cause allergies.

2023 Journal of Microbiology and Biotechnology Benefits of Soybean in the Era of Precision Medicine: A Review of Clinical Evidence
Kang JH, Dong Z, Shin SH

Chinese Medicine Research Hub

Review Article
Plums, which are rich in bioactive compounds, antioxidants, and vitamins, can help maintain blood glucose level, bone health, heart health and even treat certain cancers.

2023 International Journal of Food Properties A comprehensive review on the availability of bioactive compounds, phytochemicals, and antioxidant potential of plum ( Prunus Domestica )
Ayub H, Nadeem M, Mohsin M, Ambreen S, Khan F, Oranab S, Rahim M, Zubair khalid M, Zongo E, Zarlasht M, Ullah S

Chinese Medicine Research Hub

Network Pharmacology
The compounds apocarotenoids and carotenoids found in saffron extract could potentially interact with multiple targets, helping to manage the symptoms of polycystic ovary syndrome.

2023 Medicine Network pharmacology-based strategic prediction and target identification of apocarotenoids and carotenoids from standardized Kashmir saffron (Crocus sativus L.) extract against polycystic ovary syndrome
Tiwari A, Modi SJ, Girme A, Hingorani L

Chinese Medicine Research Hub

Experimental Study
Moderate consumption of blueberries may effectively reduce bone loss in healthy postmenopausal women.

2023 The American Journal of Clinical Nutrition Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial
Hodges JK, Maiz M, Cao S, Lachcik PJ, Peacock M, McCabe GP, McCabe LD, Cladis DP, Jackson GS, Ferruzzi MG, Lila MA, Bailey RL, Martin BR, Weaver CM

Chinese Medicine Research Hub

Meta-Analysis
Blueberry consumption significantly improves two-back test accuracy, suggesting potential cognitive benefits.

2023 CNS & Neurological Disorders - Drug Targets The Potential Effect of Blueberry on Cognitive Health and Mood State based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis
Soveid N, Barkhidarian B, Moradi S, Gholami F, Rasaei N, Himmerich H, Mirzaei K

Chinese Medicine Research Hub

Network Pharmacology
Gold kiwifruit extracts contained different bioactive materials which showed selective cytotoxic activity against human oral tumor cells and displayed anti-HIV, antioxidant, and antibacterial activities.

2023 Journal of Ethnopharmacology Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts
Motohashi N, Shirataki Y, Kawase M, Tani S, Sakagami H, Satoh K, Kurihara T, Nakashima H, Mucsi I, Varga A, Molnár J

Chinese Medicine Research Hub

Experimental Study
The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.

2023 Foods Sleep-Enhancing Effect of Water Extract from Jujube (Zizyphus jujuba Mill.) Seeds Fermented by Lactobacillus brevis L32
Bae GY, Ahn Y, Hong KB, Jung EJ, Suh HJ, Jo K

Chinese Medicine Research Hub

Review Article
The Mediterranean diet and reduced intake of trans fatty acids, saturated fatty acids, and discretionary foods like fast food and sugar-sweetened beverages may improve fertility rates.

2023 Human Reproduction Update Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies
Alesi S, Habibi N, Silva TR, Cheung N, Torkel S, Tay CT, Quinteros A, Winter H, Teede H, Mousa A, Grieger JA, Moran LJ

Chinese Medicine Research Hub

Systematic Review
Natural calcium-rich mineral waters offer a bioavailable calcium source, beneficial for bone health, cardiovascular function, weight management, and overall well-being.

2023 Nutrients Exploring the Potential Benefits of Natural Calcium-Rich Mineral Waters for Health and Wellness: A Systematic Review
Pop MS, Cheregi DC, Onose G, Munteanu C, Popescu C, Rotariu M, Turnea MA, Dograru G, Ionescu EV, Oprea D, Iliescu MG, Minea M, Stanciu LE, Silișteanu SC, Oprea C

Chinese Medicine Research Hub

Systematic Review
There is evidence to support significant improvements to total sleep time and sleep efficiency with the ingestion of tart cherries.

2023 Current Sleep Medicine Reports Too Sour to be True? Tart Cherries (Prunus cerasus) and Sleep: a Systematic Review and Meta-analysis
Stretton B, Eranki A, Kovoor J, Bacchi S, Gupta A, Maddern G, Boyd M

Chinese Medicine Research Hub

Review Article
Honey intake has observed beneficial effects on various health aspects like cardiovascular, metabolic risk factors, and wound healing, primarily replacing other sweeteners.

2023 Nutrients A Comprehensive Review of the Effect of Honey on Human Health
Palma-Morales M, Huertas JR, Rodríguez-Pérez C

Chinese Medicine Research Hub

Animal Study
Jin Si Huang Ju tea, a traditional Chinese beverage, contains compounds that potentially reduce lipids, mitigate insulin resistance and reduce liver inflammation in vitro.

2023 European Journal of Medicinal Chemistry Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease
Li X, Li R, Wang X, Zhang X, Xiao Z, Wang H, Sun W, Yang H, Yu P, Hu Q, Guo Q, Sun H

Chinese Medicine Research Hub

Systematic Review
Oat consumption can significantly improve lipid profiles, particularly reducing total cholesterol and LDL cholesterol, with potential positive effects on triglycerides and HDL cholesterol under certain conditions.

2023 Current Problems in Cardiology Effect of Oat (Avena sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-density Lipoprotein Cholesterol (HDL-C): An Updated Systematic Review
Amerizadeh A, Ghaheh HS, Vaseghi G, Farajzadegan Z, Asgary S

Chinese Medicine Research Hub

Review Article
Nutrition, particularly an anti-inflammatory Mediterranean diet supplemented with oily fish and omega-3 supplements, can potentially reduce inflammation and improve symptoms of rheumatoid arthritis.

2023 Autoimmunity Reviews Nutrition and its role in prevention and management of rheumatoid arthritis
Nikiphorou E, Philippou E

Chinese Medicine Research Hub

Review Article
Crocin, a compound derived from saffron, has shown considerable potential in hindering tumor growth and improving immune status, across various malignant tumors.

2023 PeerJ Advances on the anti-tumor mechanisms of the carotenoid Crocin
Bao X, Hu J, Zhao Y, Jia R, Zhang H, Xia L

Chinese Medicine Research Hub

Review Article
Pomegranate and its components could offer considerable potential as dietary supplements or supports in treatment for cardiovascular and non-cardiovascular diseases.

2023 Antioxidants An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate
Benedetti G, Zabini F, Tagliavento L, Meneguzzo F, Calderone V, Testai L

Chinese Medicine Research Hub

Systematic Review
Vitamin D supplementation significantly reduces pain levels in people suffering from primary dysmenorrhea.

2023 Nutrients Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Chen YC, Chiang YF, Lin YJ, Huang KC, Chen HY, Hamdy NM, Huang TC, Chang HY, Shieh TM, Huang YJ, Hsia SM

Chinese Medicine Research Hub

Review Article
Eating apples and apple products can enhance health by protecting the cardiovascular system, combating cancer and cognitive impairment, and improving hair growth, among other beneficial effects.

2023 Food Science & Nutrition Does an apple a day keep away diseases? Evidence and mechanism of action
Zhang Y, Zeng M, Zhang X, Yu Q, Zeng W, Yu B, Gan J, Zhang S, Jiang X

Chinese Medicine Research Hub

Experimental Study
Zhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties.

2023 Biomedicine & Pharmacotherapy Protective effect of ZYMT, a traditional Chinese patent medicine in a mouse model of retinitis pigmentosa
Huang Z, Huang Q, Xu K, Liang L, Li Y, Zhou W, Ning N, Zhou J, Hu J, Liu S, Dang L

Chinese Medicine Research Hub

Experimental Study
Bee-collected pollen and bee bread, particularly when artificially fermented, demonstrate significant antiviral activity against the H1N1 strain of the influenza A virus.

2023 Foods Antiviral Activity of Beebread, Bee-Collected Pollen and Artificially Fermented Pollen against Influenza A Virus
Dimitriou T, Asoutis Didaras N, Barda C, Skopeliti D, Kontogianni K, Karatasou K, Skaltsa H, Mossialos D

Chinese Medicine Research Hub

Clinical Study
Consuming two medium-sized green kiwifruits an hour before bed can improve sleep quality and recovery stress balance among elite athletes.

2023 Nutrients The Impact of Kiwifruit Consumption on the Sleep and Recovery of Elite Athletes
Doherty R, Madigan S, Nevill A, Warrington G, Ellis JG

Chinese Medicine Research Hub

Review Article
Berry fruits such as blueberries, cranberries, raspberries, and strawberries could potentially improve gut microbiota and reverse dysbiosis in chronic kidney disease patients.

2023 Nutrition Reviews Blueberry, cranberry, raspberry, and strawberry as modulators of the gut microbiota: target for treatment of gut dysbiosis in chronic kidney disease? From current evidence to future possibilities
Coutinho-Wolino KS, Melo MFS, Mota JC, Mafra D, Guimarães JT, Stockler-Pinto MB

Chinese Medicine Research Hub

Systematic Review
Saffron shows promising improvements in dealing with women's health issues related to labor, childbirth, premenstrual syndrome and menopause.

2023 Modern Care Journal Efficacy of Saffron (Crocus sativus L.) in Premenstrual Syndrome, Labor, Childbirth, and Menopause: A Systematic Review of Clinical Trials
Irani M, Rahmanian A, Soltani N

Chinese Medicine Research Hub

Systematic Review
Honey dressing significantly promotes healing and reduces recovery time in managing diabetic foot ulcers.

2023 Journal of Tissue Viability Use of honey in diabetic foot ulcer: Systematic review and meta-analysis
Yildiz Karadeniz E, Kaplan Serin E

Chinese Medicine Research Hub

Systematic Review
Consumption of natural mineral water increases diuresis in both humans and animals, evident sometimes after just one intake.

2023 International Journal of Environmental Research and Public Health Natural Mineral Water and Diuresis: A Systematic Review
Vitali M, Fontana M, De Giorgi A, Marotta D, Crucianelli S, Antonucci A, Protano C

Chinese Medicine Research Hub

Review Article
Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases.

2023 Frontiers in Nutrition Eating more sardines instead of fish oil supplementation: Beyond omega-3 polyunsaturated fatty acids, a matrix of nutrients with cardiovascular benefits
Santos HO, May TL, Bueno AA

Chinese Medicine Research Hub

Experimental Study
The anthocyanins from the Gardenblue variety of blueberries exhibit strong antiproliferative effects on various cancer cells, especially liver cancer cells.

2023 Molecules The Extraction and High Antiproliferative Effect of Anthocyanin from Gardenblue Blueberry
Zhao F, Wang J, Wang W, Lyu L, Wu W, Li W

Chinese Medicine Research Hub

Case Report
The combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.

2023 Journal of Personalized Medicine The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
Grandi G, Botticelli L, Fraia PD, Babalini C, Masini M, Unfer V

Chinese Medicine Research Hub

Clinical Study
Consuming a honey-based gel, such as 'Bear Strength honey gel,' led to a notable reduction in diastolic and mean arterial blood pressure, with gender-specific improvements in redox status among healthy adults.

2023 Biomedical Reports Evaluation of the effects of a honey‑based gel on blood redox biomarkers and the physiological profile of healthy adults: A pilot study
Patouna A, Sevdalis P, Papanikolaou K, Kourti M, Skaperda Z, Jamurtas A, Kouretas D

Chinese Medicine Research Hub

Review Article
Green tea helps alleviate symptoms in multiple benign gynecological disorders, primarily due to a compound called Epigallocatechin-3-gallate.

2023 Nutrients Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
Hazimeh D, Massoud G, Parish M, Singh B, Segars J, Islam MS

Chinese Medicine Research Hub

Randomised Controlled Trial
Consumption of fresh or dried kiwifruit in the evening improves aspects of sleep quality and mood, potentially mediated through changes in serotonin metabolism.

2023 Frontiers in Nutrition Acute effects of fresh versus dried Hayward green kiwifruit on sleep quality, mood, and sleep-related urinary metabolites in healthy young men with good and poor sleep quality
Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ

Chinese Medicine Research Hub

Korean pear extracts appear to alleviate air pollution-related respiratory hypersensitivity by modulating beneficial gut microflora and suppressing pro-inflammatory cytokines.

2023 Journal of Medicinal Food Effects of Pear Extracts on Microbiome and Immunocytokines to Alleviate Air Pollution-Related Respiratory Hypersensitivity
Yang M, Lee U, Cho HR, Lee KB, Shin YJ, Bae MJ, Park KY

Chinese Medicine Research Hub

Systematic Review
Our dose-response analysis indicated that moderate green tea consumption (500–1000 mL/d) was associated with a 21% to 24% lower risk of stroke.

2023 Nutrition Green tea consumption and the risk of stroke: A systematic review and meta-analysis of cohort studies
Wang ZM, Chen B, Zhou B, Zhao D, Wang LS

Chinese Medicine Research Hub

Systematic Review
Almond consumption can significantly reduce the serum concentration of the inflammatory mediator, Interleukin-6, in adults but no significant effect is found on C-reactive protein.

2023 Complementary Therapies in Medicine A systematic review and meta-analysis of almond effect on C-reactive protein and interleukin-6 in adults
Hariri M, Amirkalali B, Baradaran HR, Gholami A

Chinese Medicine Research Hub

Clinical Study
Preclinical studies related to osteoporosis have reported favorable effects of honey on cortical and trabecular bone microstructure, bone strength, and oxidative stress.

2023 Antioxidants Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer
Martiniakova M, Kovacova V, Mondockova V, Zemanova N, Babikova M, Biro R, Ciernikova S, Omelka R

Chinese Medicine Research Hub

Clinical Study
Clinical studies related to breast cancer have revealed that honey is effective in increasing blood cell counts, interleukin-3 levels, and quality of life.

Chinese Medicine Research Hub

Cohort Study
Ginger consumption could counteract the negative influence of disgust, induced by sexual body fluids, on sexual arousal in individuals.

2023 The Journal of Sex Research Effects of Ginger on Disgust, Sexual Arousal, and Sexual Engagement: A Placebo-Controlled Experiment
Wen G, Zhang Y, Nyman TJ, Jern P, Santtila P

Chinese Medicine Research Hub

Experimental Study
Chrysanthemum morifolium contains natural bioactive compounds, including 29 types of phenolics, which display significant antioxidant activity.

2023 Egyptian Journal of Chemistry Chemical Investigation of Phenolic Profiles and Antioxidant Activity of Chrysanthemum morifolium
Youssef H, Ali S, Sanad M, Dawood D

Chinese Medicine Research Hub

Review Article
Oats, in various edible forms, can regulate appetite hormones, aid weight management, strengthen the immune system, and contribute to gut health, making them effective for obesity management.

2023 Current Nutrition Reports Impact of Oats on Appetite Hormones and Body Weight Management: A Review
Shehzad A, Rabail R, Munir S, Jan H, Fernández-Lázaro D, Aadil RM

Chinese Medicine Research Hub

Review Article
Australian native plums contain phytochemicals that exhibit health benefits such as cardiovascular and liver protection.

2023 Food Reviews International Australian Native Plum: A Review of the Phytochemical and Health Effects
Li J, Liu H, Mazhar MS, Quddus S, Agar OT, Suleria HAR

Chinese Medicine Research Hub

Animal Study
Kiwifruit polysaccharides may alleviate the toxic effects of acrylamide by improving gut health and enhancing bile acid metabolism.

2023 Frontiers in Nutrition Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice
Chen M, Chen X, Wang K, Cai L, Liu N, Zhou D, Jia W, Gong P, Liu N, Sun Y

Chinese Medicine Research Hub

Systematic Review
Saffron supplementation significantly decreased oxidative stress markers and has beneficial effects in reducing oxidative stress.

2023 Frontiers in Medicine Effect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials
Abedi A, Ghobadi H, Sharghi A, Iranpour S, Fazlzadeh M, Aslani MR

Chinese Medicine Research Hub

Randomised Controlled Trial
Bicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life.

2023 BMJ Open Gastroenterology Heartburn relief with bicarbonate-rich mineral water: results of the randomised, placebo-controlled phase-III trial STOMACH STILL
Labenz J, Anschütz M, Walstab J, Wedemeyer RS, Wolters H, Schug B

Chinese Medicine Research Hub

Cohort Study
Regular consumption of raw carrots is associated with a significant, dose-dependent reduction in lung cancer incidence, suggesting a potential cancer-protective effect attributed to polyacetylenic compounds, particularly falcarinol and falcarindiol, present in raw carrots.

2023 Nutrients Carrot Intake and Risk of Developing Cancer: A Prospective Cohort Study
Deding U, Baatrup G, Kaalby L, Kobaek-Larsen M

Chinese Medicine Research Hub

Clinical Study
Avocado consumption correlates with a wider variety of healthier food choices, offering potential benefits for weight control strategies.

2023 PLOS One Identifying usual food choices with avocados in a clinical trial cohort of overweight and obese adults in Australia
Guan VX, Neale EP, Probst YC

Chinese Medicine Research Hub

Randomised Controlled Trial
Pomegranate extract supplements can help improve clinical symptoms and lower blood cell counts associated with inflammation in patients with allergic asthma.

2023 Frontiers in Pharmacology Does pomegranate extract supplementation improve the clinical symptoms of patients with allergic asthma? A double-blind, randomized, placebo-controlled trial
Hosseini SA, Shateri Z, Abolnezhadian F, Maraghi E, Haddadzadeh Shoushtari M, Zilaee M

Chinese Medicine Research Hub

Randomised Controlled Trial
Pomegranate juice supplementation has been found to effectively decrease testosterone levels in overweight and obese women diagnosed with polycystic ovary syndrome.

2023 Phytotherapy Research The effect of concentrated pomegranate juice on biomarkers of inflammation, oxidative stress, and sex hormones in overweight and obese women with polycystic ovary syndrome: A randomized controlled trial
Abedini M, Ramezani‐Jolfaie N, Ghasemi‐Tehrani H, Tarrahi MJ, Amani R

Chinese Medicine Research Hub

Review Article
Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.

2023 Journal of the Science of Food and Agriculture Carrot and carotene and multiple health outcomes: an umbrella review of the evidence
Yi X, Li J, Liao D, Peng G, Zheng X, Xu H, Zhang T, Ai J

Chinese Medicine Research Hub

Review Article
Honey exhibits multifaceted benefits for brain health, acting as a memory booster, neuroprotective agent, anti-stress, and anti-nociceptive substance, fostering potential therapeutic applications to enhance overall cognitive well-being.

2023 Frontiers in Aging Neuroscience Honey on brain health: A promising brain booster
Zamri NA, Ghani N, Ismail CAN, Zakaria R, Shafin N

Chinese Medicine Research Hub

Randomised Controlled Trial
The combination of dark chocolate with herbs could be one of the therapies for period pain.

2023 Journal of Tropical Pharmacy and Chemistry Effect of Combination of Dark Chocolate and Herbal Ingredients for Dysmenorrhea in Late Adolescents
Azizah RNP, Anggreini P, Prasetya F

Chinese Medicine Research Hub

Cohort Study
Heavy coffee consumption increases the risk of cardiovascular disease mortality in individuals with severe hypertension, while green tea consumption does not.

2023 Journal of the American Heart Association Coffee and Green Tea Consumption and Cardiovascular Disease Mortality Among People With and Without Hypertension
Teramoto M, Yamagishi K, Muraki I, Tamakoshi A, Iso H

Chinese Medicine Research Hub

Animal Study
Specific fractions of Lycium barbarum, commonly known as Goji berry, reduce heart and kidney damage caused by anthracyclines while possibly enhancing their therapeutic effects.

2023 Biotechnology & Biotechnological Equipment Cardio- and nephroprotective effects of fractions isolated from Lycium barbarum (goji berry) in models of cardio- and nephrotoxicity in rats
Hvarchanova N, Stoeva S, Radeva-Ilieva M, Zhelev I, Georgieva M, Dzhenkov D, Georgiev KD

Chinese Medicine Research Hub

Cohort Study
Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency.

2023 Nutrients Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor HS, Singh B, Flaminia A, Flores VA, Christman GM, Huang H, Johnson JJ, Zhang H

Chinese Medicine Research Hub

Clinical Study
Chrysanthemum extract can be utilised as a natural ingredient to lessen post-meal cholesterol levels and enhance antioxidant status, after eating a high-fat meal.

2023 Molecules Analysis of Chemical Constituents of Chrysanthemum morifolium Extract and Its Effect on Postprandial Lipid Metabolism in Healthy Adults
Chen L, Sun J, Pan Z, Lu Y, Wang Z, Yang L, Sun G

Chinese Medicine Research Hub

Network Pharmacology
Chrysanthemum has several active ingredients that can potentially treat dry eye by inhibiting inflammation-related factors and pathways, thus reducing inflammation of lacrimal gland tissue.

2023 TMR Pharmacology Research A network pharmacology-based investigation of the mechanism of action of chrysanthemum in treating dry eye
Cao LY, Long Q, Jiang PF, Peng J, Peng QH

Chinese Medicine Research Hub

Systematic Review
Carrot consumption, beyond its β- and α-carotene content, significantly reduces cancer risk, highlighting polyacetylenes as potential anti-cancer agents, urging active promotion of carrot intake.

2023 SSRN Electronic Journal Carrot Intake is Consistently Negatively Associated with Cancer Incidence: A Systematic Review and Meta-Analysis of Prospective Observational Studies
Ojobor CC, O'Brien GM, Siervo M, Ogbonnaya C, Brandt K

Chinese Medicine Research Hub

Review Article
Pomegranate and its active components can protect against natural and chemical toxic agents, impacting mechanisms such as oxidative stress, inflammation, apoptosis, and liver or cardiac function regulation.

2023 Phytomedicine Protective effects of pomegranate (Punica granatum) and its main components against natural and chemical toxic agents: A comprehensive review
Hosseini A, Razavi BM, Hosseinzadeh H

Chinese Medicine Research Hub

Review Article
Through innovative refinement, nanocurcumin, evolved from turmeric's primary component curcumin, has improved characteristics and pharmaceutical potential, particularly in drug delivery systems.

2023 Reference Series in Phytochemistry Bioactive Compounds and Biological Activities of Turmeric (Curcuma longa L.)
Jyotirmayee B, Nayak SS, Mohapatra N, Sahoo S, Mishra M, Mahalik G

Chinese Medicine Research Hub

Experimental Study
Pu-erh tea can potentially prevent depression-like behaviors induced by nighttime blue light from electronic devices by reshaping gut microbiota and increasing short-chain fatty acids generation.

2023 Food & Function Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors
Zhao S, Hu S, Sun K, Luo L, Zeng L

Chinese Medicine Research Hub

Review Article
Consumption of tea and coffee may possibly provide anti-inflammatory effects, contributing to reduced cardiovascular risk and mortality.

2023 Pharmacological Research Coffee or tea: Anti-inflammatory properties in the context of atherosclerotic cardiovascular disease prevention
Surma S, Sahebkar A, Banach M

Chinese Medicine Research Hub

Network Pharmacology
Compound Chrysanthemum extract may alleviate visual fatigue through its interaction with several components, targets, and pathways.

2022 Computational and Mathematical Methods in Medicine Network Pharmacology, Molecular Docking, and Molecular Dynamic-Based Investigation on the Mechanism of Compound Chrysanthemum in the Treatment of Asthenopia
Qiu J, Zheng B, Zhou H, Ye C, Shi M, Shi S, Wu S

Chinese Medicine Research Hub

Experimental Study
Vincentka natural mineral water reduces gastric damage and improves antioxidant capacity in an animal model of acute gastric ulcers.

2022 Physiological Research Mineral Water Vincentka and its Influence on Mucosal Ulcers
BUDINSKAYA K, NÁDENÍČEK J, STRAČINA T, HENDRYCH M, PÍREK O, BARTÁKOVÁ A, ŠUDÁKOVÁ M, SVÍZELA V, NOVÁKOVÁ Z, NOVÁKOVÁ M, BABULA P

Chinese Medicine Research Hub

Randomised Controlled Trial
Consuming green kiwifruits is associated with a clinically relevant increase of ≥ 1.5 complete spontaneous bowel movements per week in those experiencing constipation.

2022 American Journal of Gastroenterology Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort—Results of an International Multicenter Randomized Controlled Trial
Gearry R, Fukudo S, Barbara G, Kuhn-Sherlock B, Ansell J, Blatchford P, Eady S, Wallace A, Butts C, Cremon C, Barbaro MR, Pagano I, Okawa Y, Muratubaki T, Okamoto T, Fuda M, Endo Y, Kano M, Kanazawa M, Nakaya N, Nakaya K, Drummond L

Chinese Medicine Research Hub

Systematic Review
Menthacarin, derived from peppermint and caraway oil, effectively reduces symptoms, offers a safe alternative to risky drugs like cisapride, and shows promise for managing stomach problems in primary care.

2022 Digestive Diseases Menthacarin, a proprietary peppermint oil and caraway oil combination, improves multiple complaints in patients with functional gastrointestinal disorders – a systematic review and meta-analysis
Madisch A, Frieling T, Zimmermann A, Hollenz M, Labenz J, Stracke B, Miehlke S

Chinese Medicine Research Hub

Systematic Review
Avocado consumption may lead to a reduction in total cholesterol and low-density lipoprotein cholesterol levels in people with high cholesterol without impacting body weight.

2022 Journal of the Academy of Nutrition and Dietetics Avocado Consumption and Cardiometabolic Health: A Systematic Review and Meta-Analysis
James-Martin G, Brooker PG, Hendrie GA, Stonehouse W

Chinese Medicine Research Hub

Review Article
Carrot's bioactive compounds can regulate immune response, reduce oxidative stress, and prevent damaging oxidative destruction, making it a potential preventive tool for various diseases.

2022 Journal of Functional Foods Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
Anjani G, Ayustaningwarno F, Eviana R

Chinese Medicine Research Hub

Systematic Review
Tart cherry juice shows promise in aiding blood sugar control and supporting heart health, highlighting its potential as a natural dietary addition.

2022 Complementary Therapies in Medicine Effects of tart cherry juice consumption on cardio-metabolic risk factors: A systematic review and meta-analysis of randomized-controlled trials
Moosavian SP, Maharat M, Chambari M, Moradi F, Rahimlou M

Chinese Medicine Research Hub

Animal Study
Pu-erh tea and its ingredient theabrownin improve liver, jejunum, and adipose tissue functions in metabolic syndrome mice, modulating circadian rhythm, glycerophospholipid, and linoleic acid metabolism.

2022 Food Research International Pu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Hou Y, Zhang Z, Cui Y, Peng C, Fan Y, Tan C, Wang Q, Liu Z, Gong J

Chinese Medicine Research Hub

Randomised Controlled Trial
Drinking pomegranate juice and sumac can help reduce symptoms in outpatients diagnosed with COVID-19, alongside standard treatment.

2022 Mediators of Inflammation The Effect of Pomegranate Juice and Sumac Consumption in the Treatment of Outpatients with COVID-19
Forouzanfar F, Ahmadpoor M, Farahi MM, Hadianfar A, Sahebkar A, Esmaily H, Nematy M, Rakhshandeh H

Chinese Medicine Research Hub

Randomised Controlled Trial
In women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones.

2022 Frontiers in Nutrition A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial
Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, Mohammadi-Sartang M, Wong A, Babajafari S, Mazloomi SM

Chinese Medicine Research Hub

Experimental Study
The type of dairy production system can influence the overall and specific levels of microRNAs, potentially affecting the functional potential of dairy products.

2022 Veterinary Sciences Differences in the microRNAs Levels of Raw Milk from Dairy Cattle Raised under Extensive or Intensive Production Systems
Abou el qassim L, Alonso J, Zhao K, Le Guillou S, Diez J, Vicente F, Fernández-Sanjurjo M, Iglesias-Gutiérrez E, Guan L, Royo LJ

Chinese Medicine Research Hub

Cohort Study
Frequent consumption of sugar-sweetened coffee can adversely affect blood sugar control in patients with diabetes mellitus in Korea.

2022 Metabolites Sugar-Sweetened Coffee Intake and Blood Glucose Management in Korean Patients with Diabetes Mellitus
Yoo H, Park K

Chinese Medicine Research Hub

Network Pharmacology
Two varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine.

2022 International Journal of Molecular Sciences Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative Analyses
Wang Y, Li Y, Guo W, Yang X, Qu J, Gao M, Chen S, Dong J, Li Q, Wang T

Chinese Medicine Research Hub

Experimental Study
The ethanol extract from green kiwifruit peel enhances sleep duration and onset, proving to be a potential natural aid for treating sleep disorders.

2022 Nutrients Effects of Green Kiwifruit Peel Extract on Sleep-Wake Profiles in Mice: A Polysomnographic Study Based on Electroencephalogram and Electromyogram Recordings
Kim D, Yoon M, Kim S, Um MY, Cho S

Chinese Medicine Research Hub

Review Article
Green tea's catechins demonstrate therapeutic effects against neurodegenerative diseases via anti-inflammatory, antioxidant actions, and activating diverse brain cellular pathways.

2022 Molecules Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits
Afzal O, Dalhat MH, Altamimi ASA, Rasool R, Alzarea SI, Almalki WH, Murtaza BN, Iftikhar S, Nadeem S, Nadeem MS, Kazmi I

Chinese Medicine Research Hub

Review Article
Eating two gold kiwifruit daily can lead to significant improvements in mood and energy, thereby boosting psychological well-being in adults.

2022 Nutrients The Role of Kiwifruit in Supporting Psychological Well-Being: A Rapid Review of the Literature
Billows M, Kakoschke N, Zajac IT

Chinese Medicine Research Hub

Network Pharmacology
Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.

2022 Frontiers in Immunology Characterization of immunomodulatory responses induced by manuka honey
Masad RJ, Nasser RA, Bashir G, Mohamed YA, Al-Sbiei A, Al-Saafeen BH, Fernandez-Cabezudo MJ, Al-Ramadi BK

Chinese Medicine Research Hub

Review Article
Chinese jujube contains cAMP, a compound usually absent in plant cells, which may accelerate our understanding of plant cAMP metabolism.

2022 Acta Horticulturae Advances on cAMP research in Chinese jujube fruit
Yuan Y, Liu ZG, Feng C, Liu MJ

Chinese Medicine Research Hub

Experimental Study
Pu-erh tea, through the increase of Cinnabarinic acid, can improve obesity induced by circadian rhythm disorders by enhancing fat metabolism and altering gut microbes.

2022 Food Chemistry Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity
Hu S, Hu C, Luo L, Zhang H, Zhao S, Liu Z, Zeng L

Chinese Medicine Research Hub

Randomised Controlled Trial
Pomegranate extract consumption improves antioxidant levels, reduces oxidative stress and cardiovascular risk factors including blood pressure and body fat, and increases lean body mass.

2022 Antioxidants Antioxidant Properties and Beneficial Cardiovascular Effects of a Natural Extract of Pomegranate in Healthy Volunteers: A Randomized Preliminary Single-Blind Controlled Study
Al-Dujaili EAS, Casey C, Stockton A

Chinese Medicine Research Hub

Randomised Controlled Trial
A diet low in fat, vegan, and inclusive of daily cooked soybeans significantly reduces the frequency and severity of hot flashes in postmenopausal women.

2022 Menopause A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial
Barnard ND, Kahleova H, Holtz DN, Znayenko-Miller T, Sutton M, Holubkov R, Zhao X, Galandi S, Setchell KDR

Chinese Medicine Research Hub

Randomised Controlled Trial
Two gold kiwifruit daily are as effective as fiber-matched psyllium in treating constipation in adults and should be considered as a treatment option.

2022 Nutrients Two Gold Kiwifruit Daily for Effective Treatment of Constipation in Adults—A Randomized Clinical Trial
Bayer SB, Heenan P, Frampton C, Wall CL, Drummond LN, Roy NC, Gearry RB

Chinese Medicine Research Hub

Systematic Review
Kiwifruit and kiwifruit extracts may have a positive impact on constipation in adults by increasing weekly bowel movements, reducing abdominal pain, and minimizing straining.

2022 Canadian Journal of Gastroenterology and Hepatology Kiwifruit and Kiwifruit Extracts for Treatment of Constipation: A Systematic Review and Meta-Analysis
Eltorki M, Leong R, Ratcliffe EM

Chinese Medicine Research Hub

Randomised Controlled Trial
A daily intake of 50 grams of prunes can maintain hip bone density in postmenopausal women, potentially reducing hip fracture risks.

2022 The American Journal of Clinical Nutrition Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study
De Souza MJ, Strock NCA, Williams NI, Lee H, Koltun KJ, Rogers C, Ferruzzi MG, Nakatsu CH, Weaver C

Chinese Medicine Research Hub

Randomised Controlled Trial
The combined use of chamomile and saffron with usual medication enhances the efficacy against depression and ensures long term improvement.

2022 Heliyon A randomized clinical trial to test efficacy of chamomile and saffron for neuroprotective and anti-inflammatory responses in depressive patients
Ahmad S, Azhar A, Tikmani P, Rafique H, Khan A, Mesiya H, Saeed H

Chinese Medicine Research Hub

Review Article
Consuming 2-3 cups of coffee daily can help prevent cardiovascular disease and drinking at least 3 cups of green tea has similar benefits.

2022 Trends in Cardiovascular Medicine Coffee and tea on cardiovascular disease (CVD) prevention
Chieng D, Kistler PM

Chinese Medicine Research Hub

Review Article
Recent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.

2022 Melatonin Research Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey
Kim TK, Fabisiak A, Brzeminski P, Reiter RJ, Slominski AT

Chinese Medicine Research Hub

Experimental Study
Carotenoid-rich foods like orange carrots were more effective in mitigating Non-alcoholic fatty liver disease than those with low carotenoid levels.

2022 Frontiers in Nutrition Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression
Balbuena E, Cheng J, Eroglu A

Chinese Medicine Research Hub

Review Article
Adzuki beans' high lysine content, antioxidative, antibacterial, and anti-inflammatory properties highlight their dual-use as a nutritious food source and a therapeutic agent for various diseases.

2022 Molecules Nutritional Composition, Efficacy, and Processing of Vigna angularis (Adzuki Bean) for the Human Diet: An Overview
Wang Y, Yao X, Shen H, Zhao R, Li Z, Shen X, Wang F, Chen K, Zhou Y, Li B, Zheng X, Lu S

Chinese Medicine Research Hub

Randomised Controlled Trial
Consumption of wild blueberries over six months can improve cognitive performance and speed of processing information amongst older adults.

2022 Nutritional Neuroscience Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial.
Cheatham CL, Canipe LG, Millsap G, Stegall JM, Chai SC, Sheppard KW, Lila MA

Chinese Medicine Research Hub

Systematic Review
Meta-analysis revealed that lavender, particularly L. angustifolia, significantly reduces stress, making it a potentially valuable component in stress management programs.

2022 Complementary Therapies in Medicine The effect of lavender on stress in individuals: A systematic review and meta-analysis
Ghavami T, Kazeminia M, Rajati F

Chinese Medicine Research Hub

Systematic Review
Prunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women.

2022 Advances in Nutrition The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women
Damani JJ, De Souza MJ, VanEvery HL, Strock NCA, Rogers CJ

Chinese Medicine Research Hub

Review Article
Pomegranate extract and its phytochemicals can potentially inhibit severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) and improve gut microbiota, preventing obesity and diabetes.

2022 Biomedicine & Pharmacotherapy Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L. (pomegranate) plant extracts: A review
Maphetu N, Unuofin JO, Masuku NP, Olisah C, Lebelo SL

Chinese Medicine Research Hub

Experimental Study
Pomegranate juice extract may reduce the damage to the endometrium in Polycystic ovary syndrome through its antioxidant, anti-inflammatory, anti-fibrotic, and anti-proliferative effects.

2022 Morphologie Role of pomegranate extract in restoring endometrial androgen receptor expression, proliferation, and pinopodes in a rat model of polycystic ovary syndrome
Ibrahim MAA, Sadek MT, Sharaf Eldin HEM

Chinese Medicine Research Hub

Experimental Study
Using grape seed oil in the sardine canning process enhances the lipid nutritional quality and increases the fat, protein, and ash contents.

2022 Journal of Food Science and Technology Variations in nutritional quality and fatty acids composition of sardine (Sardina pilchardus) during canning process in grape seed and olive oils
Bouriga N, Rjiba Bahri W, Mili S, Massoudi S, Quignard JP, Trabelsi M

Chinese Medicine Research Hub

Experimental Study
Chrysanthemum extract has protective effects on light-damaged retinas, reducing oxidative stress and improving cellular viability.

2022 BMC Complementary Medicine and Therapies The effect of a chrysanthemum water extract in protecting the retina of mice from light damage
Gong Y, Wang X, Wang Y, Hao P, Wang H, Guo Y, Zhang W

Chinese Medicine Research Hub

Experimental Study
Oral administration of Tremella fuciformis polysaccharides may constitute a new, effective therapy for Atopic dermatitis, improving both immune response and intestinal microbiota.

2022 Frontiers in Pharmacology Tremella fuciformis polysaccharides alleviate induced atopic dermatitis in mice by regulating immune response and gut microbiota
Xie L, Yang K, Liang Y, Zhu Z, Yuan Z, Du Z

Chinese Medicine Research Hub

Randomised Controlled Trial
Chamomile sachets could be a viable alternate treatment for primary dysmenorrhea, as they've shown similar effects to mefenamic acid in reducing pain and bleeding.

2022 The Open Public Health Journal Comparing the Effect of Chamomile and Mefenamic Acid on Primary Dysmenorrhea Symptoms and Menstrual Bleeding: A Randomized Clinical Trial
Shabani F, Narenji F, Vakilian K, Zareian MA, Bozorgi M, Bioos S, Nejatbakhsh F

Chinese Medicine Research Hub

Network Pharmacology
Fresh raw wildflower honey, particularly at concentrations of 10–30%, exhibit comparable efficacy to manuka honey in inhibiting antibiotic-resistant "superbugs" implicated in wound infections, offering a potentially cost-effective alternative for wound care in the United States.

2022 Antibiotics Both Manuka and Non-Manuka Honey Types Inhibit Antibiotic Resistant Wound-Infecting Bacteria
Hewett SR, Crabtrey SD, Dodson EE, Rieth CA, Tarkka RM, Naylor K

Chinese Medicine Research Hub

Systematic Review
Aromatherapy, specifically lavender, appears to be an effective, affordable, and holistic approach to reducing the length of labour in expectant women.

2022 Journal of Obstetrics and Gynaecology Effectiveness of aromatherapy in reducing duration of labour: a systematic review
Ghiasi A, Bagheri L, Sharaflari F

Chinese Medicine Research Hub

Review Article
Depression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses.

2022 Molecules Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
Zakaria FH, Samhani I, Mustafa MZ, Shafin N

Chinese Medicine Research Hub

Randomised Controlled Trial
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.

2022 Journal of Asian Multicultural Research for Medical and Health Science Study Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia
A A, Astuti A, Leli L, Saad R

Chinese Medicine Research Hub

Review Article
Honey, owing to its bioactive compounds, demonstrates potential in treating COVID-19 symptoms by reducing oxidative damage and enhancing the immune system.

2022 Applied Sciences Honey as an Adjuvant in the Treatment of COVID-19 Infection: A Review
Soares S, Bornet M, Grosso C, Ramalhosa MJ, Gouvinhas I, Garcia J, Rodrigues F, Delerue-Matos C

Chinese Medicine Research Hub

Meta-Analysis
Green tea supplementation can significantly reduce body weight in women with polycystic ovary syndrome, hence potentially beneficial in its clinical management.

2022 Nutrition Research Green tea promotes weight loss in women with polycystic ovary syndrome: Systematic review and meta-analysis
Colonetti L, Grande AJ, Toreti IR, Ceretta LB, da Rosa MI, Colonetti T

Chinese Medicine Research Hub

Randomised Controlled Trial
Inhalation and massage therapy with lavender essential oil significantly mitigates perceived labour pain in women.

2022 Explore: The Journal of Science & Healing Determining the effect of inhalation and lavender essential oil massage therapy on the severity of perceived labor pain in primiparous women: A randomized controlled trial
Karatopuk S, Yarıcı F

Chinese Medicine Research Hub

Bananas and plantains contain compounds with anti-inflammatory, anti-apoptotic, and antioxidative properties that hold promise for potentially reversing neurological disorders.

2022 Foods Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules
Oyeyinka BO, Afolayan AJ

Chinese Medicine Research Hub

Randomised Controlled Trial
Despite previous suggestions, daily avocado consumption for six months did not decrease visceral adipose tissue volume in individuals with elevated waist circumference.

2022 Journal of the American Heart Association Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial
Lichtenstein AH, Kris‐Etherton PM, Petersen KS, Matthan NR, Barnes S, Vitolins MZ, Li Z, Sabaté J, Rajaram S, Chowdhury S, Davis KM, Galluccio J, Gilhooly CH, Legro RS, Li J, Lovato L, Perdue LH, Petty G, Rasmussen AM, Segovia‐Siapco G, Sirirat R, Su

Chinese Medicine Research Hub

Randomised Controlled Trial
Soybean lettuce extract effectively reduces symptoms of menopause syndrome without notable side effects.

2022 Nutrients Evaluation of the Effectiveness of Fermented Soybean-Lettuce Powder for Improving Menopausal Symptoms
Han AL, Lee HK, Chon HS, Pae HO, Kim MS, Shin YI, Kim S

Chinese Medicine Research Hub

Experimental Study
Goji berry supplementation can potentially improve gut microbiota and prevent liver injury caused by acute alcohol consumption.

2022 Frontiers in Nutrition Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake
Guo L, Guan Q, Duan W, Ren Y, Zhang XJ, Xu HY, Shi JS, Wang FZ, Lu R, Zhang HL, Xu ZH, Li H, Geng Y

Chinese Medicine Research Hub

Review Article
Jujube nutrients may offer potential therapeutic benefits including antioxidant, antibacterial, anti-inflammatory functions, and improving sleep quality and learning.

2022 Journal of Agricultural and Food Chemistry Wild Jujube (Ziziphus jujuba var. spinosa): A Review of Its Phytonutrients, Health Benefits, Metabolism, and Applications
Hua Y, Xu X, Guo S, Xie H, Yan H, Ma X, Niu Y, Duan JA

Chinese Medicine Research Hub

Cohort Study
Moderate consumption of carrots is associated with a lower incidence of colorectal cancer, implying a potential cancer prevention effect in a certain dose-range.

2022 Frontiers in Nutrition Association of Dietary Carrot/Carotene Intakes With Colorectal Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Jiang Z, Chen H, Li M, Wang W, Fan C, Long F

Chinese Medicine Research Hub

Randomised Controlled Trial
Avocado honey, rich in bioactive compounds, can serve as a natural sweetener without negatively impacting anthropometric and biochemical parameters.

2022 CyTA - Journal of Food Effect of avocado honey on anthropometric and biochemical parameters in healthy subjects: a pilot randomised controlled trial
Hernández Salazar M, Flores A, Ramírez E, Llaca Díaz J, Rodríguez B, Castro H

Chinese Medicine Research Hub

Animal Study
Cooked adzuki beans contribute notably to preventing obesity and regulating gut microbiota composition, while also alleviating systemic inflammation and metabolic disorders.

2022 Frontiers in Nutrition Cooked Adzuki Bean Reduces High-Fat Diet-Induced Body Weight Gain, Ameliorates Inflammation, and Modulates Intestinal Homeostasis in Mice
Zhao Q, Liu Z, Zhu Y, Wang H, Dai Z, Yang X, Ren X, Xue Y, Shen Q

Chinese Medicine Research Hub

Randomised Controlled Trial
Cocoa extract supplementation in older adults reduced cardiovascular disease related death rates, but did not significantly lessen total cardiovascular events.

2022 The American Journal of Clinical Nutrition Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
Sesso HD, Manson JAE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Carrick WR, Anderson GL

Chinese Medicine Research Hub

Review Article
Saffron plant's various parts contain bioactive compounds that, when extracted using innovative techniques, show significant potential for use in food, nutraceutical and drug formulations.

2022 Applied Food Research Bioactive constituents of saffron plant: Extraction, encapsulation and their food and pharmaceutical applications
Bakshi RA, Sodhi NS, Wani IA, Khan ZS, Dhillon B, Gani A

Chinese Medicine Research Hub

Systematic Review
Dietary strategies, such as caloric restriction and ketogenic diets, can alleviate chronic pain and enhance quality of life.

2022 International Journal of Environmental Research and Public Health The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review
Cuevas-Cervera M, Perez-Montilla J, Gonzalez-Muñoz A, Garcia-Rios M, Navarro-Ledesma S

Chinese Medicine Research Hub

Systematic Review
Higher daily tea consumption, especially green tea, is linked to a lower risk of cerebral hemorrhage in adults.

2022 Acta Neurologica Belgica Tea consumption and cerebral hemorrhage risk: a meta-analysis
Cheng P, Zhang J, Liu W, Sun Q, Fu Z, Lin H, Bi S, Zhu J

Chinese Medicine Research Hub

Animal Study
Certain natural mineral waters, when combined with a low-calorie diet, effectively reduce cholesterol and glucose levels in mice with metabolic syndrome.

2022 Frontiers in Nutrition Natural Mineral Waters and Metabolic Syndrome: Insights From Obese Male and Female C57BL/6 Mice on Caloric Restriction
Narciso L, Martinelli A, Torriani F, Frassanito P, Bernardini R, Chiarotti F, Marianelli C

Chinese Medicine Research Hub

Animal Study
Fermented gold kiwi extract exhibits antioxidant properties, providing protection to the stomach lining and reducing inflammation, making it promising for treating gastritis and gastric ulcers.

2022 Applied Sciences Gastroprotective Effects of Fermented Gold Kiwi (Actinidia chinenesis L.) Extracts on HCl/EtOH-Induced Gastric Injury in Rats
Jeon EJ, Choi JH, Lee NY, Oh HJ, Kwon HS, Kwon J

Chinese Medicine Research Hub

Experimental Study
Berries, largely due to their phenolic compounds, enhance internal antioxidant status and positively influence gut microbiota composition, promoting beneficial bacteria and suppressing harmful types.

2022 Antioxidants Evaluation of Antioxidant Capacity and Gut Microbiota Modulatory Effects of Different Kinds of Berries
Chen J, Shu Y, Chen Y, Ge Z, Zhang C, Cao J, Li X, Wang Y, Sun C

Chinese Medicine Research Hub

Review Article
Cherries and blueberries, rich in phenolic compounds, can be effectively used in pharmaceutical products, smart foods, functional beverages, and nutraceuticals to prevent or treat diseases.

2022 Molecules Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties
Gonçalves AC, Nunes AR, Flores-Félix JD, Alves G, Silva LR

Chinese Medicine Research Hub

Randomised Controlled Trial
Consuming New Zealand green kiwifruit improves sleep quality, mood, and increases the concentration of serotonin metabolites.

2022 NSNZ 2021 Acute Evening Consumption of Green Kiwifruit in Young Men Enhances Waking Alertness, Mood and Increases 5-Hydroxyindoleacetic Acid in Urine
Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ

Chinese Medicine Research Hub

Systematic Review
Ginger, native to Southeast Asia, possesses antioxidant and antiviral properties, contributing to healthy ageing and potential prevention of age-related disorders.

2022 Oxidative Medicine and Cellular Longevity Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties
Ozkur M, Benlier N, Takan I, Vasileiou C, Georgakilas AG, Pavlopoulou A, Cetin Z, Saygili EI

Chinese Medicine Research Hub

Animal Study
Walnut seed skin extract demonstrates potential hepato-renal protective effects, inhibiting inflammatory responses, oxidative stress and apoptosis, in kidney-damaged Sprague-Dawley rats.

2022 Cytokine The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia/reperfusion damage
Askin S, Askin H, Dursun E, Palabiyik E, Uguz H, Cakmak , Koc K

Chinese Medicine Research Hub

Review Article
Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects.

2022 Phytomedicine Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment
Xue P, Zhang G, Zhang J, Ren L

Chinese Medicine Research Hub

Meta-Analysis
Blueberry and cranberry consumption significantly lowered fasting blood glucose and glycated hemoglobin levels in individuals with diabetes.

2022 Nutrition, Metabolism and Cardiovascular Diseases Effects of blueberry and cranberry on type 2 diabetes parameters in individuals with or without diabetes: A systematic review and meta-analysis of randomized clinical trials
Delpino FM, Figueiredo LM, Gonçalves da Silva T, Flores TR

Chinese Medicine Research Hub

Randomised Controlled Trial
Inhalation aromatherapy using lavender and chamomile essential oils effectively reduces depression, anxiety, and stress levels in community-dwelling older adults.

2022 Explore: The Journal of Science & Healing The effects of Lavender and Chamomile essential oil inhalation aromatherapy on depression, anxiety and stress in older community-dwelling people: A randomized controlled trial
Ebrahimi H, Mardani A, Basirinezhad MH, Hamidzadeh A, Eskandari F

Chinese Medicine Research Hub

Review Article
Consuming kiwifruit, particularly the green variety, can effectively alleviate upper gastrointestinal symptoms like abdominal discomfort, pain, and indigestion.

2022 Advances in Nutrition Habitual Green Kiwifruit Consumption Is Associated with a Reduction in Upper Gastrointestinal Symptoms: A Systematic Scoping Review
Bayer SB, Frampton CM, Gearry RB, Barbara G

Chinese Medicine Research Hub

Experimental Study
Pu-erh tea may prevent circadian rhythm disorders by promoting tryptophan metabolism and signaling interactions in the gut-liver-brain axis.

2022 Journal of Agricultural and Food Chemistry Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism
Hu S, Luo L, Bian X, Liu RH, Zhao S, Chen Y, Sun K, Jiang J, Liu Z, Zeng L

Chinese Medicine Research Hub

Randomised Controlled Trial
Chamomile vaginal gel effectively improved the sexual function of postmenopausal women, and can be a potential treatment option for those unable to undergo hormone therapy.

2022 The Journal of Sexual Medicine Effect of Chamomile Vaginal Gel on the Sexual Function in Postmenopausal Women: A Double-Blind Randomized Controlled Trial
Bosak Z, Iravani M, Moghimipour E, Haghighizadeh M, Jelodarian P

Chinese Medicine Research Hub

Cohort Study
Eating more avocados, specifically two servings a week, is associated with a significantly lesser risk of cardiovascular disease and coronary heart disease.

2022 Journal of the American Heart Association Avocado Consumption and Risk of Cardiovascular Disease in US Adults
Pacheco LS, Li Y, Rimm EB, Manson JAE, Sun Q, Rexrode K, Hu FB, Guasch‐Ferré M

Chinese Medicine Research Hub

Randomised Controlled Trial
Green tea extract, specifically epigallocatechin gallate, can inhibit tumor growth and enhance the quality of life in women suffering from uterine fibroids.

2022 International Journal of Health Sciences The use of green tea in the treatment of symptomatic uterine fibroids
Badawy A, Shady NW, Maklad SMA, Ait-Allah AS

Chinese Medicine Research Hub

Meta-Analysis
Regular peanut consumption appears to positively influence lipid metabolism, reducing levels of triglycerides in the blood.

2022 Frontiers in Nutrition Effect of Peanut Consumption on Cardiovascular Risk Factors: A Randomized Clinical Trial and Meta-Analysis
Parilli-Moser I, Hurtado-Barroso S, Guasch-Ferré M, Lamuela-Raventós RM

Chinese Medicine Research Hub

Review Article
Pu-erh tea possesses therapeutic mechanisms potentially beneficial for metabolic diseases due to its interaction with liver and gut microbiome.

2022 Journal of Traditional Chinese Medical Sciences Pu-erh tea: A review of a healthful brew
Jia W, Rajani C, Lv A, Fan TP, Zheng X

Chinese Medicine Research Hub

Experimental Study
Ethanol and n-hexane extracts of Chrysanthemum indicum reveal potent anticancer activity against HepG2 cancer cells by promoting apoptosis and reducing cell proliferation.

2022 Pak-Euro Journal of Medical and Life Sciences In Vitro Study to Evaluate the Anticancer Potential of Chrysanthemum indicum, Therapeutic Plant
Mehboob Z, Sharif S, Lodhi MS, Zaigham K

Chinese Medicine Research Hub

Experimental Study
Saffron and its bioactive molecules, notably crocins, have been found to be as effective as common antidepressants in treating depression disorders.

2022 Molecules Anti-Depressant Properties of Crocin Molecules in Saffron
Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, Jafari SM

Chinese Medicine Research Hub

Systematic Review
Among the mentioned plants, castor oil and date fruit have more evidence in cervical ripening and onset of labor.

2022 Journal of Isfahan Medical School The Effect of Outpatient Herbal Drugs on Cervical Ripening and Onset of Labor: A Systematic Review and Meta-Analysis
Ghasemi M, Ebrahimzadeh-Zagami S, Ghavami V.

Chinese Medicine Research Hub

Review Article
Pomegranate juice, due to its unique bioactive compounds, could potentially alleviate complications related to SARS-CoV-2 infections, especially in patients with pre-existing chronic diseases.

2022 Journal of Nutrition and Metabolism Possible Beneficial Effects of Fresh Pomegranate Juice in SARS-CoV-2 Infection Conditions
Banihani SA

Chinese Medicine Research Hub

Review Article
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.

2022 Pharmacological Research - Modern Chinese Medicine Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, Yu MC, Lu KC, Kuo KL

Chinese Medicine Research Hub

Systematic Review
Edible medicinal plants like saffron, chamomile, dill seeds, and castor oil have demonstrated positive effects on various aspects of labor, indicating potential natural alternatives for aiding childbirth.

2022 Current Drug Discovery Technologies Edible Medicinal Plants on Facilitating Childbirth: A Systematic Review
Ivari FR, Vatanchi AM, Yousefi M, Badaksh F, Salari R

Chinese Medicine Research Hub

Clinical Study
Lavender aromatherapy is more effective in reducing pain intensity during active Phase I labor than lemon aromatherapy.

2022 Jurnal Kebidanan Comparison of The Effectiveness of Lavender and Lemon Aromatherapy Toward Reducing Pain Labor During Active Phase of First Stage
Lestari CI, Amilia R, Rospia ED

Chinese Medicine Research Hub

Randomised Controlled Trial
The intake of date palm enhances the sexual function in infertile couples.

2022 BMC Research Notes The effect of date palm on sexual function in infertile couples: a double-blind controlled clinical trial
Jahromi AR, Mosallanezhad Z, Hosini FS, Jamali S, Sharifi N

Chinese Medicine Research Hub

Review Article
Cherry juice, when consumed several days before exercise, hastens muscle function recovery post-exercise, making it a valuable 'precovery' intervention.

2022 Scandinavian Journal of Medicine & Science in Sports “Precovery” versus recovery: Understanding the role of cherry juice in exercise recovery
McHugh MP

Chinese Medicine Research Hub

Systematic Review
Higher consumption of coffee and specifically decaffeinated coffee raises the risk of rheumatoid arthritis, while caffeinated coffee, tea and caffeine intake doesn't.

2022 Frontiers in Nutrition Caffeine, Coffee, Tea and Risk of Rheumatoid Arthritis: Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies
Asoudeh F, Dashti F, Jayedi A, Hemmati A, Fadel A, Mohammadi H

Chinese Medicine Research Hub

Randomised Controlled Trial
Chamomile was found to be less effective than mefenamic acid for relieving cyclic menstrual pain.

2022 Evidence-Based Practice Is chamomile effective to treat cyclic menstrual pain?
Alcaraz EM, Laumbach SG, Amico J

Chinese Medicine Research Hub

Randomised Controlled Trial
The proprietary herbal blend LN18178 significantly boosts testosterone levels, muscle strength and mid-upper arm circumference in young, healthy males.

2022 Journal of Dietary Supplements A Proprietary Herbal Blend Containing Extracts of Punica granatum Fruit Rind and Theobroma cocoa Seeds Increases Serum Testosterone Level in Healthy Young Males: A Randomized, Double-Blind Placebo-Controlled Study
Sreeramaneni PGA, Yalamanchi A, Konda MR, Cherukuri SHV, Maroon JC

Chinese Medicine Research Hub

Review Article
Ginger, peppermint and caraway oil combination showed strong effectiveness in managing upper gastrointestinal complaints, with melatonin and marine alginate demonstrating moderate evidence.

2022 Nutrients Effectiveness of Nutritional Ingredients on Upper Gastrointestinal Conditions and Symptoms: A Narrative Review
Schulz RM, Ahuja NK, Slavin JL

Chinese Medicine Research Hub

Systematic Review
Raspberry consumption can help to reduce blood glucose levels and stabilize the blood lipid profile due to its bioactive compounds.

2022 Journal of Medicinal Food Raspberry (Rubus idaeus L.), a Promising Alternative in the Treatment of Hyperglycemia and Dyslipidemias
Piña-Contreras N, Martínez-Moreno AG, Ramírez-Anaya JDP, Espinoza-Gallardo AC, Valdés EHM

Chinese Medicine Research Hub

Review Article
Carrots, rich in carotenoids, flavonoids, and vitamins, have numerous health benefits including antioxidants, immune enhancement, and anti-cancer properties.

2022 International Journal of Innovative Research in Engineering & Management An Analysis of Health Benefits of Carrot
Varshney K, Mishra K

Chinese Medicine Research Hub

Systematic Review
Plums, specifically European and Japanese species, exhibit anti-inflammatory and antioxidant properties that may be used for the treatment and prevention of cancer.

2022 Biomedicine & Pharmacotherapy Cancer protective effects of plums: A systematic review
Bahrin AA, Moshawih S, Dhaliwal JS, Kanakal MM, Khan A, Lee KS, Goh BH, Goh HP, Kifli N, Ming LC

Chinese Medicine Research Hub

Randomised Controlled Trial
Four weeks' treatment with pomegranate supplement greatly helps in alleviating menopausal symptoms and enhancing the quality of life in menopausal women.

2022 Complementary Therapies in Medicine Effects of pomegranate supplement on menopausal symptoms and quality of life in menopausal women: A double-blind randomized placebo-controlled trial
Adel-Mehraban MS, Tansaz M, Mohammadi M, Yavari M

Chinese Medicine Research Hub

Review Article
Equol, a powerful estrogen-like compound derived from soy, could be key to better health in postmenopausal women if gut microbiome could be altered to facilitate its production.

2022 Nutrients Maximizing the Estrogenic Potential of Soy Isoflavones through the Gut Microbiome: Implication for Cardiometabolic Health in Postmenopausal Women
Leonard LM, Choi MS, Cross TWL

Chinese Medicine Research Hub

Systematic Review
Consumption of sesame seeds and its products positively influences human glucose metabolism, potentially making it a beneficial addition to glucose-lowering diets.

2022 Phytotherapy Research Consumption of sesame seeds and sesame products has favorable effects on blood glucose levels but not on insulin resistance: A systematic review and meta‐analysis of controlled clinical trials
Sohouli MH, Haghshenas N, Hernández‐Ruiz , Shidfar F

Chinese Medicine Research Hub

Clinical Study
Daily oral consumption of one avocado enhances the elasticity and firmness of the facial skin in healthy women.

2022 Journal of Cosmetic Dermatology Avocado Consumption Increased Skin Elasticity and Firmness in Women ‐ A Pilot Study
Henning SM, Guzman JB, Thames G, Yang J, Tseng CH, Heber D, Kim J, Li Z

Chinese Medicine Research Hub

Review Article
Curcumin, a spice used in Indian cooking, shows potential therapeutic effects in various retinal diseases, including during the COVID era.

2022 Graefe's Archive for Clinical and Experimental Ophthalmology Role of Curcumin in Retinal Diseases—A review
Chandrasekaran PR, Madanagopalan VG

Chinese Medicine Research Hub

Randomised Controlled Trial
A daily dose of Chrysanthemum flower extract was found to significantly reduce serum uric acid levels, potentially improving hyperuricemia.

2022 Functional Foods in Health and Disease Effects of luteolin-rich chrysanthemum flower extract on purine base absorption and blood uric acid in Japanese subjects
Takara T, Yamamoto K, Suzuki N, Yamashita S, Iio S, Kakinuma T, Baba A, Takeda S, Yamada W, Nagata M, Shimoda H

Chinese Medicine Research Hub

Review Article
Goji berries, notably their polysaccharides, exhibit protective effects against inflammatory bowel disease through the preservation of healthy gut microbiota.

2022 Critical Reviews in Food Science and Nutrition Prebiotic effects of goji berry in protection against inflammatory bowel disease
Sun Q, Du M, Kang Y, Zhu MJ

Chinese Medicine Research Hub

Meta-Analysis
Oat supplementation interventions can improve cardiovascular health markers among adults, regardless of their diet or metabolic conditions.

2022 European Journal of Nutrition Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials
Llanaj E, Dejanovic GM, Valido E, Bano A, Gamba M, Kastrati L, Minder B, Stojic S, Voortman T, Marques-Vidal P, Stoyanov J, Metzger B, Glisic M, Kern H, Muka T

Chinese Medicine Research Hub

Experimental Study
Ellagic acid, found naturally in pomegranates, significantly inhibits growth and migration of gastric cancer cells without causing notable side effects.

2022 Human & Experimental Toxicology The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells
Cheshomi H, Bahrami AR, Rafatpanah H, Matin MM

Chinese Medicine Research Hub

Meta-Analysis
Saffron intake might aid in reducing depressive symptoms but it should not be regarded as an exclusive solution for treating depression.

2022 Pharmacological Research Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis
Musazadeh V, Zarezadeh M, Faghfouri AH, Keramati M, Ghoreishi Z, Farnam A

Chinese Medicine Research Hub

Review Article
The flower of Chrysanthemum morifolium, widespread in Asia, has been discovered as a treatment for diverse diseases, including obesity, heart disease, and cancer, due to its beneficial phytoconstituents.

2022 Reference Series in Phytochemistry Chrysanthemum morifolium Ramat.: A Medicinal Plant with Diverse Traditional Uses, Bioactive Constituents, and Pharmacological Activities
Pandey J, Bastola T, Dhakal B, Poudel A, Devkota HP

Chinese Medicine Research Hub

Review Article
Chrysanthemums, popular floricultural crops, not only hold significant ornamental value but also exhibit various therapeutic potentials including antioxidant, antimicrobial, and anticancer activities.

2022 South African Journal of Botany Chrysanthemum, an ornamental genus with considerable medicinal value: A comprehensive review
Hadizadeh H, Samiei L, Shakeri A

Chinese Medicine Research Hub

Review Article
Adzuki and Mung beans have great potential as functional foods for health promotion and disease prevention, offering an excellent source of essential nutrients and biodiversity for sustainable agriculture.

2022 International Review of Neurobiology A survey of biological nitrogen fixation in adzuki beans, soybeans, and mung beans, three legumes in traditional Chinese medicine
Shahrajabian MH, Sun W, Cheng Q

Chinese Medicine Research Hub

Meta-Analysis
Isoflavone supplementation noticeably impacts menopausal symptoms and hormonal changes in postmenopausal women.

2022 Nutrition Research and Practice Effect of isoflavone supplementation on menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials
Kang I, Rim CH, Yang HS, Choe JS, Kim JY, Lee M

Chinese Medicine Research Hub

Theoretical Article
The jujube tree bears fruit endowed with substantial nutritional value and contains numerous phytochemical components with reported antioxidant, anti-cancer and neuroprotective properties.

2022 Traditional Medicine Research Jujube (Ziziphus jujuba Mill. (Rhamnaceae)): a review on its pharmacological properties and phytochemistry
Aafi E, Reza M, Mirabzadeh M

Chinese Medicine Research Hub

Systematic Review
Fresh and dried ginger displays key botanical, phytochemical and ethnopharmacological differences, which are fundamental for their specific clinical uses in treating gastrointestinal issues.

2022 The American Journal of Chinese Medicine Zingiber officinale: A Systematic Review of Botany, Phytochemistry and Pharmacology of Gut Microbiota-Related Gastrointestinal Benefits
Lai W, Yang S, Lin X, Zhang X, Huang Y, Zhou J, Fu C, Li R, Zhang Z

Chinese Medicine Research Hub

Meta-Analysis
Tea supplements, especially green tea, significantly decrease fasting blood glucose and fasting insulin levels and reduce body weight in women with polycystic ovary syndrome.

2021 Frontiers in Endocrinology Effects of Tea Consumption on Anthropometric Parameters, Metabolic Indexes and Hormone Levels of Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Shen W, Pan Y, Jin B, Zhang Z, You T, Qu Y, Han M, Yuan X, Zhang Y

Chinese Medicine Research Hub

Experimental Study
Consuming oats significantly lessens total and LDL cholesterol levels and mediates a prebiotic effect on the gut microbiome, contributing to its cholesterol-lowering ability.

2021 Frontiers in Immunology The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial
Xu D, Feng M, Chu YF, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y

Chinese Medicine Research Hub

Review Article
Fresh Hass avocados have been found to reduce cardiovascular disease risk, assist weight loss, improve cognitive function, and promote colonic microbiota health.

2021 Nutrients A Comprehensive Review of Hass Avocado Clinical Trials, Observational Studies, and Biological Mechanisms
Dreher ML, Cheng FW, Ford NA

Chinese Medicine Research Hub

Randomised Controlled Trial
Medical-grade honey outperforms conventional treatment in healing cold sores, reducing healing time and alleviating associated symptoms like pain and itching.

2021 Pharmaceuticals Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores—A Clinical Study
Naik PP, Mossialos D, Wijk B, Novakova P, Wagener FADTG, Cremers NAJ

Chinese Medicine Research Hub

Systematic Review
Turmeric curcuminoids are associated with better pain relief than NSAIDs in knee osteoarthritis.

2021 Complementary Therapies in Medicine The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis
An-Fang Hsiao, Yi-Chieh Lien, I-Shiang Tzeng, Chien-Ting Liu, Sheng-Hsun Chou, Yi-Shiung Horng

Chinese Medicine Research Hub

Review Article
Pomegranate juice and its bioactive components may serve as cost-effective, next-generation non-pharmacologic anticancer therapies, particularly against colorectal and prostate cancer.

2021 Current Drug Delivery Pomegranate, its Components, and Modern Deliverable Formulations as Potential Botanicals in the Prevention and Treatment of Various Cancers
Hussein L, Gouda M, Buttar HS

Chinese Medicine Research Hub

Review Article
Cinnamomum cassia, or cinnamon, exhibits promising therapeutic benefits in combating gastritis by targeting inflammation pathways, according to preclinical studies.

2021 Applied Biological Chemistry Potential and beneficial effects of Cinnamomum cassia on gastritis and safety: Literature review and analysis of standard extract
Lee JH, Park DH, Lee S, Seo HJ, Park SJ, Jung K, Kim SY, Kang KS

Chinese Medicine Research Hub

Experimental Study
Cocoa bean husk, a by-product of cocoa processing, exhibits potent antioxidant and anticancer effects on prostate cancer cells due to its high phenolic compound content.

2021 Molecular & Cellular Toxicology Antioxidant and apoptotic activity of cocoa bean husk extract on prostate cancer cells
Choi J, Yang C, Lim W, Song G, Choi H

Chinese Medicine Research Hub

Review Article
The pomegranate plant has a rich inventory of phytochemical constituents showing pharmacological efficiency in treating cardiovascular and endocrine diseases.

2021 Journal of Nutrition and Metabolism Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials
Eghbali S, Askari SF, Avan R, Sahebkar A

Chinese Medicine Research Hub

Randomised Controlled Trial
High avocado intake significantly reduces the intake of energy and various macro and micronutrients in Hispanic/Latino families.

2021 Nutrients Effects of Different Allotments of Avocados on the Nutritional Status of Families: A Cluster Randomized Controlled Trial
Pacheco LS, Bradley RD, Denenberg JO, Anderson CAM, Allison MA

Chinese Medicine Research Hub

Systematic Review
Eating kiwifruits improves bowel movements and decreases stool consistency, also providing anti-inflammatory and antioxidant benefits to the gut barrier.

2021 Future Pharmacology Kiwifruit (Actinidia spp.) Dietary Consumption for Constipation: A Systematic Review and Meta-Analysis
Antonelli M, Donelli D

Chinese Medicine Research Hub

Cohort Study
Consumption of sardines can effectively prevent type 2 diabetes mellitus and hypertension, particularly in senior citizens, due to their high omega 3, EPA, and DHA content.

2021 Muhammadiyah International Public Health and Medicine Proceeding The Benefits of Consuming Sardines to Prevent Hypertension and Type 2 Diabetes Mellitus for Senior Citizens
Nurdiana Febriyanti V

Chinese Medicine Research Hub

Cohort Study
Sardines are highly proven to be able to effectively prevent type 2 diabetes, prevent hypertension, and lower blood pressure, especially for senior citizens.

Chinese Medicine Research Hub

Randomised Controlled Trial
Date fruit consumption appears to be useful for promoting and increasing breast milk quantity in breastfeeding mothers. Date fruits may be an alternative galactagogue.

2021 Breastfeeding Medicine The Effects of Date Fruit Consumption on Breast Milk Quantity and Nutritional Status of Infants
Modepeng T, Pavadhgul P, Bumrungpert A, Kitipichai W

Chinese Medicine Research Hub

Systematic Review
Date fruit consumption several weeks prior to delivery can decrease the need for labor induction and/or augmentation and might have a beneficial effect on labor duration.

2021 Explore: The Journal of Science & Healing The effect of late pregnancy date fruit consumption on delivery progress – A meta-analysis
Sagi-Dain L, Sagi S

Chinese Medicine Research Hub

Randomised Controlled Trial
Consumption of one avocado per day can potentially reduce visceral adiposity and subsequently decrease the risk of diabetes and cardiovascular disease.

2021 Contemporary Clinical Trials The design and rationale of a multi-center randomized clinical trial comparing one avocado per day to usual diet: The Habitual Diet and Avocado Trial (HAT)
Reboussin DM, Kris-Etherton PM, Lichtenstein AH, Li Z, Sabate J, Matthan NR, Petersen K, Rajaram S, Vitolins M, Ford N

Chinese Medicine Research Hub

Randomised Controlled Trial
Inhalation of chamomile oil significantly reduces pain after cesarean section in first-time mothers, decreasing the need for analgesics.

2021 Current Reviews in Clinical and Experimental Pharmacology Effect of Chamomile Oil on Cesarean Section Pain in Primiparous Women: A Randomized Clinical Trial
Zardosht R, Basiri A, Sahebkar A, Emami SA

Chinese Medicine Research Hub

Systematic Review
Green tea treatment has shown potential in improving oral hygiene and gingival health, and reducing periodontitis and caries.

2021 Japanese Dental Science Review Impact of Green Tea (Camellia Sinensis) on periodontitis and caries. Systematic review and meta-analysis
Mazur M, Ndokaj A, Jedlinski M, Ardan R, Bietolini S, Ottolenghi L

Chinese Medicine Research Hub

Systematic Review
Green tea supplementation improves total antioxidant capacity and impacts oxidative stress based on dose levels in adults.

2021 Antioxidants Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Rasaei N, Asbaghi O, Samadi M, Setayesh L, Bagheri R, Gholami F, Soveid N, Casazza K, Wong A, Suzuki K, Mirzaei K

Chinese Medicine Research Hub

Systematic Review
Cinnamon supplementation may significantly enhance metabolic status in women with polycicstic ovary syndrome, notably improving high-density lipoprotein and insulin sensitivity, and decreasing low-density lipoprotein, triglyceride, and blood glucose levels.

2021 Journal of Ovarian Research Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review
Maleki V, Faghfouri AH, Tabrizi FPF, Moludi J, Saleh-Ghadimi S, Jafari-Vayghan H, Qaisar SA

Chinese Medicine Research Hub

Experimental Study
Tiger nut and walnut supplementation in diets can improve testosterone levels and help control vasoconstriction, potentially benefiting hypertensive individuals.

2021 Nutrients Cyperus esculentus L. and Tetracarpidium conophorum Müll. Arg. Supplemented Diet Improved Testosterone Levels, Modulated Ectonucleotidases and Adenosine Deaminase Activities in Platelets from L-NAME-Stressed Rats
Olabiyi AA, Morsch VM, Oboh G, Schetinger MRC

Chinese Medicine Research Hub

Review Article
Green tea and its component EGCG, demonstrate potential as a treatment for endometriosis by inhibiting growth, invasion, adhesion and angiogenesis.

2021 Critical Reviews in Food Science and Nutrition Therapeutic effects of green tea on endometriosis
Chen X, Man GCW, Hung SW, Zhang T, Fung LWY, Cheung CW, Chung JPW, Li TC, Wang CC

Chinese Medicine Research Hub

Review Article
Cocoa, including its often discarded shell, has promising potential in providing benefits to human health due to its high content of health-boosting phytochemicals.

2021 Journal of Food Composition and Analysis Cocoa and cocoa bean shells role in human health: An updated review
Cinar Z, Atanassova M, Tumer TB, Caruso G, Antika G, Sharma S, Sharifi-Rad J, Pezzani R

Chinese Medicine Research Hub

Randomised Controlled Trial
Chamomile capsules prove effective in reducing emotional symptoms related to menstrual cycles.

2021 European Journal of Obstetrics & Gynecology and Reproductive Biology: X The effect of Matricaria chamomile on menstrual related mood disorders
Najafi Mollabashi E, Ziaie T, Bostani Khalesi Z

Chinese Medicine Research Hub

Review Article
Lavender aromatherapy, whether administered through massage or inhalation, appears effective in reducing active phase labor pain.

2021 Disease and Diagnosis Effect of Aromatherapy with Lavender on Labor Pain: A Literature Review
Hatami Rad R

Chinese Medicine Research Hub

Systematic Review
Almond-based diets may be effective in promoting short-chain fatty acid-producing bacteria and lowering glycated haemoglobin and body mass index in patients with type 2 diabetes compared with control.

2021 Nutrients The Effects of Almonds on Gut Microbiota, Glycometabolism, and Inflammatory Markers in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Ojo O, Wang XH, Ojo OO, Adegboye ARA

Chinese Medicine Research Hub

Clinical Study
Consumption of green tea enriched with a citrus polyphenol, α-glucosyl hesperidin, can prevent weight gain and reduce body mass index, especially in individuals under 50 years.

2021 Scientific Reports The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial
Yoshitomi R, Yamamoto M, Kumazoe M, Fujimura Y, Yonekura M, Shimamoto Y, Nakasone A, Kondo S, Hattori H, Haseda A, Nishihira J, Tachibana H

Chinese Medicine Research Hub

Systematic Review
Green tea extract could be considered a potential agent to attenuate PCOS complications mainly due to its effect on weight loss and glycemic levels.

2021 Reproductive Biology and Endocrinology A comprehensive insight into effects of green tea extract in polycystic ovary syndrome: a systematic review
Maleki V, Taheri E, Varshosaz P, Tabrizi FPF, Moludi J, Jafari-Vayghan H, Shadnoush M, Jabbari SHY, Seifoleslami M, Alizadeh M

Chinese Medicine Research Hub

Systematic Review
Soy food intake, particularly fermented soy products, appear to have a protective effect on fracture risk among Asian women, especially in early menopause.

2021 Complementary Medicine Research Soy Foods and the Risk of Fracture: A Systematic Review of Prospective Cohort Studies
Akhavan Zanjani M, Rahmani S, Mehranfar S, Zarrin M, Bazyar H, Moradi Poodeh B, Zare Javid A, Hosseini SA, Sadeghian M

Chinese Medicine Research Hub

Animal Study
Adzuki beans, when added to a high-fat diet, lessen obesity, improve liver function, enhance insulin sensitivity, and balance gut microbiota.

2021 Nutrients Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice
Zhao Q, Hou D, Fu Y, Xue Y, Guan X, Shen Q

Chinese Medicine Research Hub

Randomised Controlled Trial
Pomegranate extract supplement shows potential in improving glycemic indicators, serum lipids, anthropometrics, and blood pressure in patients with nonalcoholic fatty liver disease.

2021 Phytotherapy Research The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double‐blind clinical trial
Goodarzi R, Jafarirad S, Mohammadtaghvaei N, Dastoorpoor M, Alavinejad P

Chinese Medicine Research Hub

Randomised Controlled Trial
A new method for assessing the effects of therapies on atherosclerosis shows that pomegranate juice/extract has a significant influence on carotid vessel-wall-plus-plaque thickness.

2021 Ultrasound in Medicine & Biology Three-dimensional ultrasound assessment of effects of therapies on carotid atherosclerosis using vessel wall thickness maps
Zhao Y, Spence JD, Chiu B

Chinese Medicine Research Hub

Systematic Review
Chocolate and cocoa product consumption significantly improved lipid profiles, but had no significant effect on other heath aspects such as cognitive function and blood pressure.

2021 Nutrients The Health Effects of Chocolate and Cocoa: A Systematic Review
Tan TYC, Lim XY, Yeo JHH, Lee SWH, Lai NM

Chinese Medicine Research Hub

Network Pharmacology
A combination of extracts from chrysanthemum were found to be more effective in treating hyperuricemia and potentially developing anti-hyperuricemic functional foods.

2021 Plants Hypouricemic Effects of Chrysanthemum indicum L. and Cornus officinalis on Hyperuricemia-Induced HepG2 Cells, Renal Cells, and Mice
Kim OK, Yun JM, Lee M, Kim D, Lee J

Chinese Medicine Research Hub

Experimental Study
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.

2021 Complementary Therapies in Medicine Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data
Coyle ME, Liu J, Yang H, Wang K, Zhang AL, Guo X, Lu C, Xue CC

Chinese Medicine Research Hub

Systematic Review
Drinking coffee may be linked to lower mortality risk in type 2 diabetes patients.

2021 Nutrition, Metabolism and Cardiovascular Diseases Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose–response meta-analysis of cohort studies
Shahinfar H, Jayedi A, Khan TA, Shab-Bidar S

Chinese Medicine Research Hub

Review Article
Pu-erh tea, with its complex components, interacts greatly with gut microbiomes and holds significant potential for healthcare applications.

2021 Food Chemistry Effects of bioactive components of Pu-erh tea on gut microbiomes and health: A review
Liu JY, He D, Xing YF, Zeng W, Ren K, Zhang C, Lu Y, Yang S, Ou SJ, Wang Y, Xing XH

Chinese Medicine Research Hub

Experimental Study
Zeaxanthin dipalmitate, a wolfberry-derived carotenoid, can delay retinal degeneration in mice modelling Retinitis Pigmentosa mainly through its anti-inflammatory and oxidative stress effects.

2021 Journal of Neurochemistry Wolfberry‐derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways
Liu F, Liu X, Zhou Y, Yu Y, Wang K, Zhou Z, Gao H, So KF, Vardi N, Xu Y

Chinese Medicine Research Hub

Systematic Review
A variety of Chinese herbal medicines have been reported to effectively prevent or treat nonalcoholic fatty liver disease by regulation of the gut microbiota and the gut-liver axis.

2021 Chinese Medicine Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology
Yang XF, Lu M, You L, Gen H, Yuan L, Tian T, Li CY, Xu K, Hou J, Lei M

Chinese Medicine Research Hub

Animal Study
Adzuki bean extracts have shown more potential than black soybean extracts in lowering blood pressure in hypertensive rats, acting on the renin-angiotensin system.

2021 Foods Black Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats
Jeong EW, Park SY, Yang YS, Baek YJ, Yun DM, Kim HJ, Go GW, Lee HG

Chinese Medicine Research Hub

Animal Study
Omega-3 fatty acids found in selected fish oils, particularly smoked eel, effectively managed dyslipidemia and reduced cardiovascular disease risk factors.

2021 Journal of Medicinal Food Influence of Omega-3 Fatty Acid-Rich Fish Oils on Hyperlipidemia: Effect of Eel, Sardine, Trout, and Cod Oils on Hyperlipidemic Mice
Kontostathi M, Isou S, Mostratos D, Vasdekis V, Demertzis N, Kourounakis A, Vitsos A, Kyriazi M, Melissos D, Tsitouris C, Karalis E, Klamarias L, Dania F, Papaioannou GT, Roussis V, Polychronopoulos E, Anastassopoulou J, Theophanides T, Rallis MC, Black H

Chinese Medicine Research Hub

Experimental Study
Chrysanthemum, a traditional Chinese medicine, shows significant antioxidant activity and hepatoprotective effects, making it a potential resource for functional foods and medicinal materials.

2021 Chemistry & Biodiversity Comparison of Chemical Constituents and Pharmacological Effects of Different Varieties of Chrysanthemum Flos in China
Chen L, Liu Y, Huang X, Zhu Y, Li J, Miao Y, Du H, Liu D

Chinese Medicine Research Hub

Systematic Review
Green tea consumption has been found to be effective in preventing the contraction of influenza infections.

2021 Molecules Anti-Influenza with Green Tea Catechins: A Systematic Review and Meta-Analysis
Rawangkan A, Kengkla K, Kanchanasurakit S, Duangjai A, Saokaew S

Chinese Medicine Research Hub

Systematic Review
Ginger significantly improves sperm health, enhancing quality parameters like count, viability, motility, morphology and DNA integrity, thereby boosting fertility.

2021 Veterinary Medicine and Science A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans
Gholami‐Ahangaran M, Karimi‐Dehkordi M, Akbari Javar A, Haj Salehi M, Ostadpoor M

Chinese Medicine Research Hub

Review Article
The date palm enhances both male and female fertility parameters through its nutritional attributes and antioxidant functionality.

2021 Metabolites Therapeutic Potential of Date Palm against Human Infertility: A Review
Shehzad M, Rasheed H, Naqvi SA, Al-Khayri JM, Lorenzo JM, Alaghbari MA, Manzoor MF, Aadil RM

Chinese Medicine Research Hub

Experimental Study
Tremella fuciformis polysaccharides effectively reduce inflammation in ulcerative colitis, promoting healing by restoring intestinal and mucus barrier functions.

2021 International Journal of Biological Macromolecules Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function
Xu Y, Xie L, Zhang Z, et al

Chinese Medicine Research Hub

Review Article
Date palm tree products and by-products are exceptionally rich in bioactive compounds offering potential health benefits, therefore suitable to be used as natural ingredients in food manufacturing.

2021 Food Reviews International Date Fruit and Its By-products as Promising Source of Bioactive Components: A Review
Echegaray N, Gullón B, Pateiro M, Amarowicz R, Misihairabgwi JM, Lorenzo JM

Chinese Medicine Research Hub

Review Article
Almonds can support colonic microbiota health by promoting microflora richness and diversity, increasing the ratio of symbiotic to pathogenic microflora, and concentrations of health-promoting colonic bioactives.

2021 Nutrients A Comprehensive Review of Almond Clinical Trials on Weight Measures, Metabolic Health Biomarkers and Outcomes, and the Gut Microbiota
Dreher ML

Chinese Medicine Research Hub

Review Article
Recent systematic reviews and meta-analyses of nut RCTs showed that almonds were the only nut that had a small but significant decrease in both mean body mass and fat mass, compared to control diets.

2021 Nutrients A Comprehensive Review of Almond Clinical Trials on Weight Measures, Metabolic Health Biomarkers and Outcomes, and the Gut Microbiota
Dreher ML

Chinese Medicine Research Hub

Systematic Review
The consumption of cocoa or dark chocolate can reduce low-density lipoprotein cholesterol and fasting blood sugar levels in diabetic patients.

2021 Phytotherapy Research The effect of cocoa/dark chocolate consumption on lipid profile, glycemia, and blood pressure in diabetic patients: A meta‐analysis of observational studies
Darand M, Hajizadeh Oghaz M, Hadi A, Atefi M, Amani R

Chinese Medicine Research Hub

Review Article
In reproductive health, honey can improve infertility, protect the postmenopausal reproductive tract, prevent toxic effects, maintain sperm quality by restoring testosterone levels and treat vulvovaginal candidiasis infections.

2021 Molecules Protective Roles of Honey in Reproductive Health: A Review
Zaid SSM, Ruslee SS, Mokhtar MH

Chinese Medicine Research Hub

Review Article
Curcumin, with its anti-inflammatory, antioxidant, antimicrobial and antimutagenic properties, is a potential therapeutic agent for retinal diseases.

2021 Clinical Ophthalmology Recent Advances and Disputes About Curcumin in Retinal Diseases
Nebbioso M, Franzone F, Greco A, Gharbiya M, Bonfiglio V, Polimeni A

Chinese Medicine Research Hub

Experimental Study
Fructus Lycii and Salvia miltiorrhiza Bunge extract improve retinal morphology and function by regulating the Nrf2/HO-1 pathway to curb oxidative reactions.

2021 Journal of Ethnopharmacology Fructus Lycii and Salvia miltiorrhiza Bunge extract alleviate retinitis pigmentosa through Nrf2/HO-1 signaling pathway
Ou C, Jiang P, Tian Y, Yao Z, Yang Y, Peng J, Zeng M, Song H, Peng Q

Chinese Medicine Research Hub

Randomised Controlled Trial
Lavandula angustifolia essential oil inhalation seemed to enhance overall sleep patterns, quality, and efficiency in postmenopausal women with insomnia.

2021 Complementary Therapies in Medicine Lavender essential oil on postmenopausal women with insomnia: Double-blind randomized trial
dos Reis Lucena L, dos Santos-Junior JG, Tufik S, Hachul H

Chinese Medicine Research Hub

Systematic Review
Phytoestrogens, used in various forms, have shown improvement in urogenital menopause symptoms and improved women's sexual function, promoting overall quality of life.

2021 European Journal of Obstetrics & Gynecology and Reproductive Biology Impact of phytoestrogens on treatment of urogenital menopause symptoms: A systematic review of randomized clinical trials
Abdi F, Rahnemaei FA, Roozbeh N, Pakzad R

Chinese Medicine Research Hub

Clinical Study
Green tea therapy can significantly improve rheumatoid arthritis symptoms, correlating with changes in specific circulating serum molecules, miR-125b and miR-146a.

2021 Journal of Herbal Medicine Circulating microRNAs expression as predictors of clinical response in rheumatoid arthritis patients treated with green tea
Al-Rawaf HA, Alghadir AH, Gabr SA

Chinese Medicine Research Hub

Review Article
There is a notable gap in scientific research on the potential health benefits and antioxidant activity of matcha tea compared to green tea.

2021 Applied Sciences Retrospecting the Antioxidant Activity of Japanese Matcha Green Tea–Lack of Enthusiasm?
Sivanesan I, Gopal J, Muthu M, Chun S, Oh JW

Chinese Medicine Research Hub

Randomised Controlled Trial
Consumption of blueberry supplement did not show significant improvement in metabolic health markers, however, it induced changes in gene expression, indicating a potential longer-term effect.

2021 Genes & Nutrition An 8-week freeze-dried blueberry supplement impacts immune-related pathways: a randomized, double-blind placebo-controlled trial
Rousseau M, Horne J, Guénard F, de Toro-Martín J, Garneau V, Guay V, Kearney M, Pilon G, Roy D, Couture P, Couillard C, Marette A, Vohl MC

Chinese Medicine Research Hub

Systematic Review
Cocoa-rich products consumption can improve mood and affect in the short term.

2021 Critical Reviews in Food Science and Nutrition The effect of cocoa-rich products on depression, anxiety, and mood: A systematic review and meta-analysis
Fusar-Poli L, Gabbiadini A, Ciancio A, Vozza L, Signorelli MS, Aguglia E

Chinese Medicine Research Hub

Review Article
Green tea and its chief bioactive component have the potential to improve certain female reproductive disorders such as endometriosis, polycystic ovary syndrome, and dysmenorrhea.

2021 Molecules Beneficial Effects of Green Tea Catechins on Female Reproductive Disorders: A Review
Kamal DAM, Salamt N, Zaid SSM, Mokhtar MH

Chinese Medicine Research Hub

Randomised Controlled Trial
Eating sardines twice a week for a year significantly reduces the risk of developing type 2 diabetes in prediabetic individuals aged 65 and above.

2021 Clinical Nutrition Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial
Díaz-Rizzolo DA, Serra A, Colungo C, Sala-Vila A, Sisó-Almirall A, Gomis R

Chinese Medicine Research Hub

Randomised Controlled Trial
A one-year, sardine-enriched diet in an elderly population with pre-diabetes exerts a greater protective effect against developing type 2 diabetes and cardiovascular events.

Chinese Medicine Research Hub

Experimental Study
Black pepper and its major component, piperine, can effectively regulate anemia of inflammation by reducing the overexpression of hepcidin, a hormone that controls iron levels.

2021 Free Radical Biology and Medicine Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway
Banerjee S, Katiyar P, Kumar L, Kumar V, Saini SS, Krishnan V, Sircar D, Roy P

Chinese Medicine Research Hub

Systematic Review
Coffee consumption, particularly boiled coffee, may increase levels of certain cardiovascular risk markers, but no strong link was found to anti-inflammatory effects.

2021 The American Journal of Medicine Impact of Coffee Consumption on Physiological Markers of Cardiovascular Risk: A Systematic Review
Daneschvar HL, Smetana GW, Brindamour L, Bain PA, Mukamal KJ

Chinese Medicine Research Hub

Randomised Controlled Trial
Combining resistance training with saffron supplementation enhances happiness levels and increases dopamine and serotonin concentrations more than resistance training alone.

2021 Physiology & Behavior Impact of saffron (Crocus Sativus Linn) supplementation and resistance training on markers implicated in depression and happiness levels in untrained young males
Moghadam BH, Bagheri R, Roozbeh B, Ashtary-Larky D, Gaeini AA, Dutheil F, Wong A

Chinese Medicine Research Hub

Systematic Review
Consumption of certain foods like rapeseed/canola oil, avocados, and turmeric can lead to moderate to large reductions in LDL cholesterol levels.

2021 Nutrition, Metabolism and Cardiovascular Diseases The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials
Schoeneck M, Iggman D

Chinese Medicine Research Hub

Review Article
Pomegranate has a variety of phytochemicals which possess wide-ranging activities including antioxidant, antimicrobial, anti-oncogenic properties, and resistance to cerebrovascular disease.

2021 Journal of Ethnopharmacology A unique understanding of traditional medicine of pomegranate, Punica granatum L. and its current research status
Ge S, Duo L, Wang J, GegenZhula , Yang J, Li Z, Tu Y

Chinese Medicine Research Hub

Experimental Study
Two French natural mineral waters (NMW1 and NMW2) show anti-inflammatory effects and can reduce intestinal inflammation in mice with induced colitis.

2021 International Journal of Molecular Sciences Beneficial Effects of Natural Mineral Waters on Intestinal Inflammation and the Mucosa-Associated Microbiota
Barnich N, Rodrigues M, Sauvanet P, Chevarin C, Denis S, Le Goff O, Faure-Imbert D, Hanh T, Roques CF, Chassaing B, Alric M

Chinese Medicine Research Hub

Systematic Review
Tremella polysaccharide is a safe natural active ingredient, which can be used in the prevention, treatment and rehabilitation of diseases.

2021 International Journal of Immunopathology and Pharmacology A review on the production, structure, bioactivities and applications of Tremella polysaccharides
Ma, X., Yang, M., He, Y., Zhai, C., & Li, C.

Chinese Medicine Research Hub

Randomised Controlled Trial
Adding oat bran to the diet of pregnant women with gestational diabetes can help significantly reduce their fasting and postprandial blood glucose levels.

2021 BMC Endocrine Disorders The effect of oat bran consumption on gestational diabetes: a randomized controlled clinical trial
Barati Z, Iravani M, Karandish M, Haghighizadeh MH, Masihi S

Chinese Medicine Research Hub

Randomised Controlled Trial
Avocado/soy unsaponifiables effectively treat osteoarthritis by controlling the balance between oxidant and antioxidant molecular markers.

2021 Journal of Complementary and Integrative Medicine Avocado/soy unsaponifiables can redress the balance between serum antioxidant and oxidant levels in patients with osteoarthritis: a double-blind, randomized, placebo-controlled, cross-over study
Jangravi Z, Basereh S, Zaree Mahmoudabadi A, Saberi M, Alishiri GH, Korani M

Chinese Medicine Research Hub

Systematic Review
These results indicate that a certain concentration of snow fungus polysaccharides can effectively alleviate skin damage caused by UVA, and they may be used as an effective component of cosmetics.

2021 Journal of Cosmetic Dermatology Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways
Fu H, You S, Zhao D, An Q, Zhang J, Wang C, Wang D, Li M.

Chinese Medicine Research Hub

Systematic Review
Epidemiological studies suggest that the consumption of spicy chilli food is associated with reduced risk of all-cause as well as heart disease–related mortality.

2021 Angiology Association of Spicy Chilli Food Consumption With Cardiovascular and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies
Ofori-Asenso R, Mohsenpour MA, Nouri M, Faghih S, Liew D, Mazidi M.

Chinese Medicine Research Hub

Systematic Review
Isoflavones found in soybeans can reduce risks of certain cancers and alleviate menopause-related symptoms among women, such as vasomotor syndromes, spinal bone loss, and hypertension.

2021 International Journal of Molecular Sciences Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview
Chen LR, Chen KH

Chinese Medicine Research Hub

Cohort Study
Moderate coffee consumption may potentially reduce the risk of low HDL-C and high fasting blood glucose amongst Korean male adults.

2021 Nutrients Association of Coffee Consumption and Its Types According to Addition of Sugar and Creamer with Metabolic Syndrome Incidence in a Korean Population from the Health Examinees (HEXA) Study
Tan LJ, Jeon HJ, Park SH, Kim SA, Lim K, Chung S, Chang PS, Lee J, Kang D, Shin S

Chinese Medicine Research Hub

Review Article
Pomegranate demonstrates anti-proliferative, anti-oxidant, anti-inflammatory properties that can effectively control the progression of various respiratory diseases.

2021 Journal of Food Biochemistry Therapeutic properties of Punica granatum L (pomegranate) and its applications in lung‐based diseases: A detailed review
Shaikh SB, Bhandary YP

Chinese Medicine Research Hub

Systematic Review
A systematic analysis indicates that ginger has a higher safety profile than NSAIDs for pain relief, with a smaller number of gastric side effects and fewer kidney risks.

2021 Cureus Journal of Medical Science Efficacy of Ginger in the Treatment of Primary Dysmenorrhea: A Systematic Review and Meta-analysis
Negi R, Sharma DS, Gaur DR, Bahadur A, Jelly P

Chinese Medicine Research Hub

Systematic Review
Based on beneficial effects and minimal side effects, ginger may be a potential adjunct treatment for primary dysmenorrhea.

2021 Cureus Journal of Medical Science Efficacy of Ginger in the Treatment of Primary Dysmenorrhea: A Systematic Review and Meta-analysis
Negi R, Sharma DS, Gaur DR, Bahadur A, Jelly P

Chinese Medicine Research Hub

Review Article
Saffron and its components, crocin and crocetin, show potential in treating various eye disorders, including inflammation, macular edema, and glaucoma.

2021 Current Neuropharmacology Pharmacological Effects of Saffron and its Constituents in Ocular Disorders from in vitro Studies to Clinical Trials: A Systematic Review
Sepahi S, Ghorani-Azam A, Hossieni SM, Mohajeri SA, Khodaverdi E

Chinese Medicine Research Hub

Review Article
Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.

2021 Molecules Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies
Ali AM, Kunugi H

Chinese Medicine Research Hub

Clinical Study
Pomegranate polyphenols have shown strong potential in preventing and treating breast cancer through various anti-cancer effects.

2021 Molecules Pharmacological and Therapeutic Properties of Punica granatum Phytochemicals: Possible Roles in Breast Cancer
Moga MA, Dimienescu OG, Bălan A, Dima L, Toma SI, Bîgiu NF, Blidaru A

Chinese Medicine Research Hub

Systematic Review
Raspberry leaf for childbirth, highlighting the lack of robust evidence on its effects, safety, and efficacy during pregnancy, emphasizing the need for more comprehensive research.

2021 BMC Complementary Medicine and Therapies Biophysical effects, safety and efficacy of raspberry leaf use in pregnancy: a systematic integrative review
Bowman R, Taylor J, Muggleton S, Davis D

Chinese Medicine Research Hub

Experimental Study
Supplementation with standardized saffron extract improves depressive symptoms and social relationships in healthy individuals experiencing subclinical low mood and stress.

2021 Frontiers in Nutrition Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial
Jackson PA, Forster J, Khan J, Pouchieu C, Dubreuil S, Gaudout D, Moras B, Pourtau L, Joffre F, Vaysse C, Bertrand K, Abrous H, Vauzour D, Brossaud J, Corcuff JB, Capuron L, Kennedy DO

Chinese Medicine Research Hub

Animal Study
Traditional fermented products made from soybeans and rice, commonly consumed in the Japanese diet, show significant potential in preventing the progression of fatty liver disease.

2021 Foods Protection of Fatty Liver by the Intake of Fermented Soybean Paste, Miso, and Its Pre-Fermented Mixture
Kanno R, Koshizuka T, Miyazaki N, Kobayashi T, Ishioka K, Ozaki C, Chiba H, Suzutani T

Chinese Medicine Research Hub

Randomised Controlled Trial
Enriching a regular diet with oat β-glucan can improve glycemic control, augment feelings of fullness, and positively modulate gut microbiota in individuals with type-2 diabetes.

2021 Journal of Functional Foods Effect of dietary supplementation with oat β-glucan for 3 months in subjects with type 2 diabetes: A randomized, double-blind, controlled clinical trial
Pino JL, Mujica V, Arredondo M

Chinese Medicine Research Hub

Experimental Study
Pomegranate juice extract (PPJE) appears to reduce chemotherapy-induced skin side effects by inhibiting inflammation and promoting wound repair on the skin.

2021 Antioxidants Protective Effect of Pomegranate on Oxidative Stress and Inflammatory Response Induced by 5-Fluorouracil in Human Keratinocytes
Rapa SF, Magliocca G, Pepe G, Amodio G, Autore G, Campiglia P, Marzocco S

Chinese Medicine Research Hub

Systematic Review
Current evidence shows that short-term honey supplementation following surgical or physiological menopause exerts an oestrogenic, antioxidant and anti-inflammatory effect on the female reproductive system.

2021 Molecules Augmentation of the Female Reproductive System Using Honey: A Mini Systematic Review
Ismail NH, Ibrahim SF, Jaffar FHF, Mokhtar MH, Chin KY, Osman K

Chinese Medicine Research Hub

Review Article
Honey, traditionally a food item, exhibits therapeutic properties—anti-microbial, anti-inflammatory, anti-cancer, and wound healing—showing promise in managing and preventing allergic diseases, as supported by scientific evidence and clinical studies.

2021 Frontiers in Pharmacology The Potential use of Honey as a Remedy for Allergic Diseases: A Mini Review
Aw Yong PY, Islam F, Harith HH, Israf DA, Tan JW, Tham CL

Chinese Medicine Research Hub

Review Article
Green tea, coffee, wine, and curry have beneficial health effects due to the polyphenols they contain, which possess both antioxidant and pro-oxidant properties.

2021 Molecules The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity
Ohishi T, Fukutomi R, Shoji Y, Goto S, Isemura M

Chinese Medicine Research Hub

Systematic Review
The existing evidence, although with low level of confidence, suggests that walnut intake may have a beneficial effect on cognition-related outcomes, including cognitive function, mood, and stroke.

2021 Annals of Medicine Walnut intake, cognitive outcomes and risk factors: a systematic review and meta-analysis
Cahoon, D., Shertukde, S. P., Avendano, E. E., Tanprasertsuk, J., Scott, T. M., Johnson, E. J., Chung, M., & Nirmala, N.

Chinese Medicine Research Hub

Review Article
Goji berries have significant potential as a natural medicine in anticancer efforts due to their high content of active compounds.

2021 International Review of Neurobiology Chapter 35 - Lycium barbarum (goji berry), human breast cancer, and antioxidant profile
Anna Wawruszaka,Marta Halasaa,Karolina Oklab

Chinese Medicine Research Hub

Clinical Study
Consumption of blueberries can alter levels of certain beneficial compounds in the blood, potentially contributing to improved cognitive function in older adults.

2021 Food & Function Blueberry phenolics are associated with cognitive enhancement in supplemented healthy older adults
Rutledge GA, Sandhu AK, Miller MG, Edirisinghe I, Burton-Freeman BB, Shukitt-Hale B

Chinese Medicine Research Hub

Review Article
Phytochemicals in carrots, particularly carotenoids, are effective at reducing eyesight degeneration and treating chronic eye defects due to their antioxidant and anti-inflammatory properties.

2021 SSRN Electronic Journal The Nutraceutical potential of Carrots carotenoids in Chronic Eyes Defects (CEDs): A Review
Taiwo EA, Abdulkareem TT, Fajemisin E

Chinese Medicine Research Hub

Clinical Study
Alkaline drinking water significantly improves spine bone density in postmenopausal women with osteoporosis, more than standard treatment alone.

2021 Journal of Menopausal Medicine Effect of Alkaline Drinking Water on Bone Density of Postmenopausal Women with Osteoporosis
Fasihi S, Fazelian S, Farahbod F, Moradi F, Dehghan M

Chinese Medicine Research Hub

Systematic Review
Almond intake significantly changed the concentrations of triglycerides, total cholesterol and low-density lipoproteins

2021 Food & Function The effect of almond intake on lipid profile: a systematic review and meta-analysis of randomized controlled trials
Asbaghi O, Moodi V, Hadi A, Eslampour E, Shirinbakhshmasoleh M, Ghaedi E, Miraghajani M

Chinese Medicine Research Hub

Experimental Study
Pomegranate seed oil, rich in conjugated linolenic acid, potentially acts as a cytotoxic agent on tissue tumor cells, reducing polycystic ovary syndrome manifestations.

2021 JBRA Assisted Reproduction The effect of pomegranate seed oil on human health, especially epidemiology of polycystic ovary syndrome; a systematic review
Bahmani M, Shokri S, Akhtar ZN, Abbaszadeh S, Manouchehri A

Chinese Medicine Research Hub

Experimental Study
Ginger honey supplementation does not reduce cortisol levels, however, it significantly increases glutathione and estrogen levels in test mice.

2021 Gaceta Sanitaria Ginger honey affects cortisol, estrogen and glutathione levels; preliminary study to target preconceptional women
Usman AN, Raya I, Yasmin R, Aliyah , Dirpan A, Arsyad A, Permatasari AE, Sumidarti A, Umami N, Emmasitah

Chinese Medicine Research Hub

Meta-Analysis
The study reveals that pomegranate juice does not significantly affect vascular adhesion factors, but can effectively reduce the inflammatory marker, interleukin-6.

2021 Phytomedicine Effect of pomegranate juice on vascular adhesion factors: A systematic review and meta-analysis
Asgary S, Karimi R, Joshi T, Kilpatrick KL, Moradi S, Samimi Z, Mohammadi E, Farzaei MH, Bishayee A

Chinese Medicine Research Hub

Systematic Review
Higher coffee consumption, specifically 3-4 cups daily, is associated with a 21% lower risk of stroke, with no further reductions with increased intake.

2021 Journal of Stroke and Cerebrovascular Diseases Coffee Consumption and Stroke Risk: Evidence from a Systematic Review and Meta-Analysis of more than 2.4 Million Men and Women
Shao C, Tang H, Wang X, He J

Chinese Medicine Research Hub

Review Article
Tea and coffee possess health promoting properties and can effectively prevent and treat metabolic disorders, including obesity, through the suppression of fat storage.

2021 Physiological Research The anti-obesity and health-promoting effects of tea and coffee
Sirotkin AV, Kolesarova A

Chinese Medicine Research Hub

Experimental Study
Ginger supplementation can prevent ethanol-induced reproductive dysfunction by improving hormone levels, reducing oxidative damage, inflammation, and regulating genes involved in testosterone synthesis.

2021 Brazilian Archives of Biology and Technology Ginger (Zingiber officinale Roscoe) Improves Ethanol-Induced Reproductive Dysfunction by Enhancing Steroidogenesis and Inhibiting Oxidative Stress and Inflammation
Li N, Xing Y, Sultan AH, Raeeszadeh M, Akbari A, Liu H

Chinese Medicine Research Hub

Systematic Review
The supplementary intake of green tea does not significantly affect blood glucose, fasting insulin, hemoglobin A1c, and insulin resistance in patients with type 2 diabetes mellitus.

2021 Diabetes & Metabolic Syndrome: Clinical Research & Reviews Effect of green tea on glycemic control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
Asbaghi O, Fouladvand F, Gonzalez MJ, Ashtary-Larky D, Choghakhori R, Abbasnezhad A

Chinese Medicine Research Hub

Randomised Controlled Trial
Walnut consumption coupled with concurrent training improves lipid profile, steroid hormone levels, and systematic inflammation in elderly men.

2021 Biology of Sport Moderate walnut consumption improved lipid profile, steroid hormones and inflammation in trained elderly men: a pilot study with a randomized controlled trial
Kamoun A, Hammouda O, Turki M, Maaloul R, Chtourou M, Bouaziz M, Driss T, Souissi N, Chamari K, Ayadi F

Chinese Medicine Research Hub

Review Article
Coffee's bioactive compounds may exhibit various health benefits such as antioxidant and anti-inflammatory properties on the digestive tract and stimulating effects on motor function.

2020 Nutrients Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis
Iriondo-DeHond A, Uranga JA, del Castillo MD, Abalo R

Chinese Medicine Research Hub

Review Article
Regular coffee consumption, due to its bioactive compounds, may have protective effects against chronic disorders and certain neurodegenerative conditions.

2020 International Journal of Molecular Sciences Neuroprotective Effects of Coffee Bioactive Compounds: A Review
Socała K, Szopa A, Serefko A, Poleszak E, Wlaź P

Chinese Medicine Research Hub

Review Article
Isoflavones, mainly found in soy-derived products, show beneficial effects on bone health, potential cancer risk reduction, and alleviation of menopausal symptoms, but not on cardiovascular risk.

2020 Nutrients Scientific Evidence Supporting the Beneficial Effects of Isoflavones on Human Health
Gómez-Zorita S, González-Arceo M, Fernández-Quintela A, Eseberri I, Trepiana J, Portillo MP

Chinese Medicine Research Hub

Systematic Review
Regular walnut consumption is consistently linked to improved cognitive performance in adults, particularly those at higher risk of cognitive decline.

2020 Advances in Nutrition Nut Consumption for Cognitive Performance: A Systematic Review
Lauren E Theodore, Nicole J Kellow, Emily A McNeil, Evangeline O Close, Eliza G Coad, Barbara R Cardoso,

Chinese Medicine Research Hub

Randomised Controlled Trial
DKB114, a mixture of Linn flower extract, effectively reduces serum uric acid level, suggesting its potential as a dietary supplement for hyperuricemia treatment.

2020 Nutrients A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial for Evaluation of the Efficacy and Safety of DKB114 on Reduction of Uric Acid in Serum
Park YH, Kim DH, Lee JS, Jeong HI, Lee KW, Kang TH

Chinese Medicine Research Hub

Randomised Controlled Trial
Consumption of jujube seed had a positive impact on improving the sleep quality of postmenopausal women and could be recommended as a useful herbal medication.

2020 BioMedicine Investigation the effect of jujube seed capsule on sleep quality of postmenopausal women: A double-blind randomized clinical trial
Mahmoudi R, Ansari S, Haghighizadeh MH, Maram NS, Montazeri S.

Chinese Medicine Research Hub

Randomised Controlled Trial
Daily consumption of tart cherry juice may reduce processes involved in accelerated atherogenesis, potentially decreasing the risk of cardiovascular diseases.

2020 Journal of Medicinal Food Effects of Montmorency Tart Cherry Juice Consumption on Cardiometabolic Biomarkers in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Trial
Johnson SA, Navaei N, Pourafshar S, Jaime SJ, Akhavan NS, Alvarez-Alvarado S, Proaño GV, Litwin NS, Clark EA, Foley EM, George KS, Elam ML, Payton ME, Arjmandi BH, Figueroa A

Chinese Medicine Research Hub

Review Article
Jujube fruits contain a high amount of various bioactive compounds exerting antioxidant, anti-inflammatory, antiobesity, anti-cardiovascular disease, hepatoprotective, antidiabetic, anti-microbial, anticancer, and gastrointestinal-protective effects.

2020 Journal of Functional Foods Jujube fruit: A potential nutritious fruit for the development of functional food products
Rashwan, A. K, Karim, N., Shishir, M. Rezaul Islam, Bao, T., Lu, Y., & Chen, W.

Chinese Medicine Research Hub

Systematic Review
Consuming walnuts does not significantly alter blood glucose levels, indicating cardiovascular protective effects of walnuts are not due to improved glycaemic control.

2020 British Journal of Nutrition Effect of walnut consumption on markers of blood glucose control: a systematic review and meta-analysis
Neale, E., Guan, V., Tapsell, L., & Probst, Y.

Chinese Medicine Research Hub

Experimental Study
Green tea polyphenolic compounds, (-)-epigallocatechin (EGC) and (-)-epicatechin-3-gallate (ECG), can diminish harmful Alzheimer's disease linked Aβ aggregates and ameliorate symptoms.

2020 Bioorganic Chemistry Inhibition of Aβ aggregates in Alzheimer’s disease by epigallocatechin and epicatechin-3-gallate from green tea
Chen T, Yang Y, Zhu S, Lu Y, Zhu L, Wang Y, Wang X

Chinese Medicine Research Hub

Review Article
Omega-3 polyunsaturated fatty acids supplementation during the prenatal and perinatal period could have a protective effect on neurodevelopmental disorders including ADHD, ASD, and MDD in youth.

2020 Clinical Psychopharmacology and Neuroscience Nutritional Neuroscience as Mainstream of Psychiatry: The Evidence- Based Treatment Guidelines for Using Omega-3 Fatty Acids as a New Treatment for Psychiatric Disorders in Children and Adolescents
Chang JPC, Su KP

Chinese Medicine Research Hub

Experimental Study
Mineral water increases the diversity of gut microbiota by aiding the growth of Bacteroidetes taxa.

2020 Journal of Water and Health The effect of different drinking water in culture medium on feces microbiota diversity
Zhou K, Liu W, Chen Z, Yang D, Qiu Z, Feng H, Li C, Jin M, Li J, Xu Q, Shen Z

Chinese Medicine Research Hub

Review Article
Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.

2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
Chen J, Tsim KWK

Chinese Medicine Research Hub

Review Article
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.

2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
Chen J, Tsim KWK

Chinese Medicine Research Hub

Experimental Study
Chrysanthemum coronarium L. extract can both stimulate bone building cells and inhibit bone breaking cells, so has potential as a natural treatment for osteoporosis.

2020 Evidence-Based Complementary and Alternative Medicine Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo
Kim SA, Lee AS, Hur HJ, Lee SH, Sung MJ

Chinese Medicine Research Hub

Systematic Review
Green tea consumption notably reduces body weight, body mass index, and body fat, especially in long-term use, at lower dosages, and among overweight individuals with type-2 diabetes.

2020 Complementary Medicine Research Effect of Green Tea on Anthropometric Indices and Body Composition in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Asbaghi O, Fouladvand F, Gonzalez MJ, Aghamohammadi V, Choghakhori R, Abbasnezhad A

Chinese Medicine Research Hub

Systematic Review
Lavender can decrease the severity of labor pain, which could influence health policy makers and gynecologists.

2020 Evidence-Based Complementary and Alternative Medicine The Effect of Lavender (Lavandula stoechas L.) on Reducing Labor Pain: A Systematic Review and Meta-Analysis
Kazeminia M, Abdi A, Vaisi-Raygani A, Jalali R, Shohaimi S, Daneshkhah A, Salari N, Mohammadi M

Chinese Medicine Research Hub

Cohort Study
Habitual and high-frequency tea consumption, particularly green tea, is associated with a reduced prevalence of cognitive impairment in middle-aged and older individuals.

2020 BMC Geriatrics Association between tea consumption and cognitive impairment in middle-aged and older adults
Zhang J, Wang A, Zhang X, Chen S, Wu S, Zhao X, Zhang Q

Chinese Medicine Research Hub

Randomised Controlled Trial
Incorporating tree nuts into a Western-style diet subtly modifies specific DNA methylation regions within sperm, thereby showing parts of the sperm epigenome can respond to dietary changes.

2020 Andrology Sperm DNA methylation changes after short‐term nut supplementation in healthy men consuming a Western‐style diet
Salas‐Huetos A, James ER, Salas‐Salvadó J, Bulló M, Aston KI, Carrell DT, Jenkins TG

Chinese Medicine Research Hub

Randomised Controlled Trial
Incorporating daily doses of walnuts into the diet of elderly individuals significantly reduces the concentrations of several inflammatory biomarkers.

2020 Journal of the American College of Cardiology Effects of 2-Year Walnut-Supplemented Diet on Inflammatory Biomarkers
Cofán M, Rajaram S, Sala-Vila A, Valls-Pedret C, Serra-Mir M, Roth I, Freitas-Simoes TM, Bitok E, Sabaté J, Ros E

Chinese Medicine Research Hub

Review Article
Catechin-rich green tea extract (GTE) exercised anti-inflammatory activities can be beneficial in managing Nonalcoholic fatty liver disease (NAFLD) by reducing liver injury and gut-derived endotoxins.

2020 The Journal of Nutritional Biochemistry Anti-inflammatory activities of green tea catechins along the gut–liver axis in nonalcoholic fatty liver disease: lessons learned from preclinical and human studies
Hodges JK, Sasaki GY, Bruno RS

Chinese Medicine Research Hub

Review Article
Honey's phytochemical components and bioactive compounds have potential antiviral effects, potentially making it an effective natural product against COVID-19.

2020 Molecules Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanisms of Action and Future Directions
Al-Hatamleh MAI, Hatmal MM, Sattar K, Ahmad S, Mustafa MZ, Bittencourt MDC, Mohamud R

Chinese Medicine Research Hub

Review Article
Juhua, the flower head of Chrysanthemum morifolium Ramat, possesses multiple medicinal properties and has a significant role in dietary herbal medicine in China.

2020 Journal of Ethnopharmacology The flower head of Chrysanthemum morifolium Ramat. (Juhua): A paradigm of flowers serving as Chinese dietary herbal medicine
Yuan H, Jiang S, Liu Y, Daniyal M, Jian Y, Peng C, Shen J, Liu S, Wang W

Chinese Medicine Research Hub

Review Article
Green tea catechins potentially contribute to maintaining joint and skeletal muscle health, mitigating symptoms of osteoarthritis and sarcopenia.

2020 Antioxidants Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition
Luk HY, Appell C, Chyu MC, Chen CH, Wang CY, Yang RS, Shen CL

Chinese Medicine Research Hub

Experimental Study
Pomegranate juice increases the effectiveness of lung cancer treatment with the low dose chemotherapy drug Cisplatin, while simultaneously reducing its toxicity on normal cells.

2020 Medicines Pomegranate Juice Extract Decreases Cisplatin Toxicity on Peripheral Blood Mononuclear Cells
Nasser M, Damaj Z, Hijazi A, Merah O, Al-Khatib B, Hijazi N, Trabolsi C, Damaj R, Nasser M

Chinese Medicine Research Hub

Review Article
Beverages, through their diverse nutritional contents, have notable effects on rheumatoid arthritis progression by interacting with immune signaling pathways and altering the microbiome.

2020 Nutrients Beverages in Rheumatoid Arthritis: What to Prefer or to Avoid
Dey M, Cutolo M, Nikiphorou E

Chinese Medicine Research Hub

Experimental Study
The major components of green tea and coffee, EGCG and CGA respectively, may have anti-cancer effects, though these effects seem to vary for different types of cancer.

2020 Molecules Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid
Hayakawa S, Ohishi T, Miyoshi N, Oishi Y, Nakamura Y, Isemura M

Chinese Medicine Research Hub

Review Article
Pomegranate possesses significant biological and nutraceutical value with potential applications against a wide spectrum of diseases due to its rich phytochemical composition.

2020 Applied Sciences Pomegranate: Nutraceutical with Promising Benefits on Human Health
Caruso A, Barbarossa A, Tassone A, Ceramella J, Carocci A, Catalano A, Basile G, Fazio A, Iacopetta D, Franchini C, Sinicropi MS

Chinese Medicine Research Hub

Randomised Controlled Trial
Daily consumption of decaffeinated green tea catechins may enhance working memory.

2020 Molecules Effect of Daily Intake of Green Tea Catechins on Cognitive Function in Middle-Aged and Older Subjects: A Randomized, Placebo-Controlled Study
Baba Y, Inagaki S, Nakagawa S, Kaneko T, Kobayashi M, Takihara T

Chinese Medicine Research Hub

Systematic Review
The consumption of green tea significantly lowers low-density lipoprotein cholesterol and total cholesterol, but it does not affect high-density lipoprotein cholesterol or triglycerides.

2020 Nutrition Journal Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials
Xu R, Yang K, Li S, Dai M, Chen G

Chinese Medicine Research Hub

Randomised Controlled Trial
The use of ginger, chamomile, and honey significantly diminished the intensity of dysmenorrhea pain as compared to the use of mefenamic acid.

2020 Current Women s Health Reviews The Effect of Ginger-chamomile Sachet with Honey on Primary Dysmenorrhea and Associated Symptoms: A Randomized, Double-Blind, Controlled Trial
Shabani F, Chabra A, Vakilian K, Bioos S, Bozorgi M, Ayati MH, Nejatbakhsh F

Chinese Medicine Research Hub

Randomised Controlled Trial
Inhalation aromatherapy using Damask rose and lavender essential oils can reduce anxiety and pain in women after they have had a cesarean section.

2020 Journal of Complementary and Integrative Medicine Compare the effect of aromatherapy using lavender and Damask rose essential oils on the level of anxiety and severity of pain following C-section: A double-blinded randomized clinical trial
Abbasijahromi A, Hojati H, Nikooei S, Jahromi HK, Dowlatkhah HR, Zarean V, Farzaneh M, Kalavani A

Chinese Medicine Research Hub

Systematic Review
Lavender demonstrates significant benefits for pain relief and episiotomy wound healing in postpartum.

2020 Complementary Therapies in Medicine The effect of Lavender on pain and healing of episiotomy: A systematic review
Abedian S, Abedi P, Jahanfar S, Iravani M, Zahedian M

Chinese Medicine Research Hub

Systematic Review
The most important tremella mushroom benefits are anti-aging, anti-inflammatory, lower cholesterol, combat obesity, protect nerves and may fight cancer.

2020 Amazonian Journal of Plant Research Chemical compounds and health benefits of Tremella, a valued mushroom as both cuisine and medicine in ancient China and modern era
Mohamad Hesam Shahrajabian, Wenli Sun, Hong Shen and Qi Cheng

Chinese Medicine Research Hub

Randomised Controlled Trial
Fenugreek improves breast milk production in mothers and increases the weight gain of newborns during their first week of life.

2020 Clinical Epidemiology and Global Health Effect of fenugreek on breast milk production and weight gain among Infants in the first week of life
Ravi R, Joseph J

Chinese Medicine Research Hub

Systematic Review
Cinnamon supplementation significantly decreases inflammation and oxidative stress levels, serving as a potential additive for cardiometabolic health improvement.

2020 Complementary Therapies in Medicine Impact of Cinnamon Supplementation on cardiometabolic Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Zhu, Changyou; Yan, Hongmei; Yin, Zheng; Santos, Heitor O; Melahat Sedanur Macit; et al

Chinese Medicine Research Hub

Meta-Analysis
Supplementation with blueberry shows a potential for beneficial impact on reducing body weight, which might indirectly influence cardiovascular disease risk factors.

2020 Complementary Therapies in Medicine Blueberry and cardiovascular disease risk factors: A systematic review and meta-analysis of randomized controlled trials
Miraghajani M, Momenyan S, Arab A, Hasanpour Dehkordi A, Symonds ME

Chinese Medicine Research Hub

Review Article
Green tea and its compounds, especially catechins, may potentially prevent and treat osteoarthritis due to their potent antioxidant and anti-inflammatory properties.

2020 Longhua Chinese Medicine The possible role of green tea on osteoarthritis: a narrative report
Barbalho SM, Goulart RA, Buglio DS, Araujo AC, Guiguer EL

Chinese Medicine Research Hub

Review Article
Green tea polyphenols can potentially protect against neurodegenerative disorders like Parkinson's Disease through antioxidant, anti-inflammatory, and neuroprotective actions.

2020 Molecules Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review
Malar DS, Prasanth MI, Brimson JM, Sharika R, Sivamaruthi BS, Chaiyasut C, Tencomnao T

Chinese Medicine Research Hub

Systematic Review
The literature overall supports an inverse association between green tea and cardiovascular disease-related health outcomes, while the included meta-analyses generally suggested an inverse association between green tea and BMI-related and blood pressure outcomes.

2020 European Journal of Clinical Nutrition Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence
Abe SK, Inoue M

Chinese Medicine Research Hub

Systematic Review
Higher consumption of coffee correlates with a significant decrease in the risk of liver cancer or hepatocellular carcinoma.

2020 Journal of Gastrointestinal and Liver Diseases Inverse Association of Coffee with Liver Cancer Development: An Updated Systematic Review and Meta-analysis
Bhurwal A, Ratta P, Yoshitake S, Pioppo L, Reja D, Dellatore P, Rustgi V

Chinese Medicine Research Hub

Systematic Review
Honey can be used as an alternative to antibiotics by clinicians who wish to offer treatment for upper respiratory tract infections, which may help to combat antimicrobial resistance.

2020 BMJ Evidence-Based Medicine Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis
Abuelgasim H, Albury C, Lee J

Chinese Medicine Research Hub

Systematic Review
Honey is more effective than usual care alternatives for improving upper respiratory tract infection symptoms, particularly cough frequency and cough severity.

2020 BMJ Evidence-Based Medicine Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis
Abuelgasim H, Albury C, Lee J

Chinese Medicine Research Hub

Clinical Study
Montmorency tart cherry juice can significantly improve blood pressure, fasting glucose, cholesterol rates and respiratory exchange ratio in those with metabolic syndrome.

2020 European Journal of Nutrition Effects of short-term continuous Montmorency tart cherry juice supplementation in participants with metabolic syndrome
Desai T, Roberts M, Bottoms L

Chinese Medicine Research Hub

Review Article
In jujube fruit, the contents of sugar, vitamin C, and cyclic adenosine monophosphate (cAMP) are around 2, 100, and 1000 times those of apple, respectively.

2020 Horticulture Research The historical and current research progress on jujube-a superfruit for the future
Liu, M., Wang, J., Wang, L. et al.

Chinese Medicine Research Hub

Randomised Controlled Trial
Concentrated pomegranate juice consumption can potentially lower cardiovascular disease risk factors in women with polycystic ovary syndrome.

2020 Phytotherapy Research The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: A randomized controlled trial
Abedini M, Ghasemi‐Tehrani H, Tarrahi MJ, Amani R

Chinese Medicine Research Hub

Randomised Controlled Trial
A botanical formula of lutein ester, zeaxanthin, and extracts from blackcurrant, chrysanthemum, and goji berry can effectively lessen eye fatigue and improve macular function.

2020 The American Journal of Clinical Nutrition A novel botanical formula improves eye fatigue and dry eye: a randomized, double-blind, placebo-controlled study
Kan J, Wang M, Liu Y, Liu H, Chen L, Zhang X, Huang C, Liu BY, Gu Z, Du J

Chinese Medicine Research Hub

Review Article
Honey, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile.

2020 The Journal of Nutritional Biochemistry Honey and obesity-related dysfunctions: a summary on health benefits
Terzo S, Mulè F, Amato A

Chinese Medicine Research Hub

Clinical Study
Magnesium-rich mineral water effectively treats and prevents constipation in children, leading to regular, painless bowel movements.

2020 Russian Journal of Physiotherapy, Balneology and Rehabilitation The use of magnesium-containing mineral waters for functional constipation in children and adolescents
Kulikov AG, Zakharova IN, Tvorogova TM, Stepurina LL, Elezova LI

Chinese Medicine Research Hub

Network Pharmacology
Chrysanthemum morifolium Ramat. ethanol extract (CEE) presents a potential protective effect on lipopolysaccharide induced acute lung injury in mice.

2020 BMC Complementary Medicine and Therapies Protective effect of Chrysanthemum morifolium Ramat. ethanol extract on lipopolysaccharide induced acute lung injury in mice
Liu G, Zheng Q, Pan K, Xu X

Chinese Medicine Research Hub

Systematic Review
Green tea supplementation significantly lowers fasting glucose levels but does not significantly affect fasting insulin and haemoglobin A1c values.

2020 Nutrition & Metabolism Effects of green tea consumption on glycemic control: a systematic review and meta-analysis of randomized controlled trials
Xu R, Bai Y, Yang K, Chen G

Chinese Medicine Research Hub

Systematic Review
The study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba.

2020 Evidence-Based Complementary and Alternative Medicine Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review
Su-Rong He, Chong-Bo Zhao, Jing-Xia Zhang, Jing Wang, Bo Wu, Chun-Jie Wu,

Chinese Medicine Research Hub

Network Pharmacology
Seasonal variations influence the nutrient composition of European sardines, with lipid levels peaking from July to September and amino acid content highest during winter.

2020 Foods Seasonal Changes in Free Amino Acid and Fatty Acid Compositions of Sardines, Sardina pilchardus (Walbaum, 1792): Implications for Nutrition
Šimat V, Hamed I, Petričević S, Bogdanović T

Chinese Medicine Research Hub

Systematic Review
Green tea extract supplement intake reduces serum triglyceride and total cholesterol in patients with type 2 diabetes mellitus, especially when used long term.

2020 Diabetes & Metabolic Syndrome: Clinical Research & Reviews Effect of green tea extract on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
Asbaghi O, Fouladvand F, Moradi S, Ashtary-Larky D, Choghakhori R, Abbasnezhad A

Chinese Medicine Research Hub

Systematic Review
For primary dysmenorrhoea, cinnamon/fennel/ginger effectively reduced pain intensity, and cinnamon shortened the duration of pain.

2020 Journal of International Medical Research Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials
Xu Y, Yang Q, Wang X

Chinese Medicine Research Hub

Experimental Study
Probiotic-enriched mung and adzuki bean sprouts demonstrate increased antioxidant potential and exhibit cytostatic and cytotoxic effects on human stomach cancer cells.

2020 Molecules Potentially Bioaccessible Phenolics from Mung Bean and Adzuki Bean Sprouts Enriched with Probiotic—Antioxidant Properties and Effect on the Motility and Survival of AGS Human Gastric Carcinoma Cells
Świeca M, Herok A, Piwowarczyk K, Sikora M, Ostanek P, Gawlik-Dziki U, Kapusta I, Czyż J

Chinese Medicine Research Hub

Cocoa polyphenols promote gut health by favorably altering gut microbiota composition and producing secondary bioactive metabolites with antioxidant and anti-inflammatory properties.

2020 Nutrients Cocoa Polyphenols and Gut Microbiota Interplay: Bioavailability, Prebiotic Effect, and Impact on Human Health
Sorrenti V, Ali S, Mancin L, Davinelli S, Paoli A, Scapagnini G

Chinese Medicine Research Hub

Review Article
Black pepper, particularly the piperine it contains, enhances the absorption of iron, potentially improving athletic performance in endurance sports.

2020 Nutrients Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications
Fernández-Lázaro D, Mielgo-Ayuso J, Córdova Martínez A, Seco-Calvo J

Chinese Medicine Research Hub

Theoretical Article
Coffee, like many fruits and vegetables, activates a cellular response that boosts antioxidants and repair enzymes, which contributes to a lower risk of several diseases.

2020 Nutrients Health Effects of Coffee: Mechanism Unraveled?
Kolb H, Kempf K, Martin S

Chinese Medicine Research Hub

Randomised Controlled Trial
The use of standardized saffron extract appears to show significant improvement in sleep quality in healthy adults with self-reported sleep issues.

2020 Journal of Clinical Sleep Medicine Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial
Lopresti AL, Smith SJ, Metse AP, Drummond PD

Chinese Medicine Research Hub

Experimental Study
Honey contains 20(S)-Hydroxyvitamin D3 (20(OH)D3) and its derivatives, including 20(OH)-7DHC, 25(OH)D3, and 1,25(OH)2D3, indicating their production in bees and suggesting potential health implications.

2020 Molecules Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey
Kim TK, Atigadda V, Brzeminski P, Fabisiak A, Tang EKY, Tuckey RC, Slominski AT

Chinese Medicine Research Hub

Experimental Study
We determined the concentration of 20(OH)D3 in honey to be 0.26 µg/g, corresponding to approximately 10 IU/g.

2020 Molecules Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey
Kim TK, Atigadda V, Brzeminski P, Fabisiak A, Tang EKY, Tuckey RC, Slominski AT

Chinese Medicine Research Hub

Systematic Review
Green tea catechins-containing mouthwash may potentially be a practical alternative to chlorhexidine due to its efficacy in plaque reduction and minimal side effects.

2020 Journal of Herbal Medicine The Effect of Green Tea on plaque and gingival inflammation: A systematic review
Gartenmann SJ, Steppacher SL, von Weydlich Y, Heumann C, Attin T, Schmidlin PR

Chinese Medicine Research Hub

Systematic Review
Clinical trials categorize botanical parts of date palm as being most effective in eight different areas such as obstetrics, oncology, and endocrinology.

2020 Complementary Therapies in Medicine Clinical effects of date palm (Phoenix dactylifera L.): A systematic review on clinical trials
Bagherzadeh karimi A, Elmi A, Zargaran A, Mirghafourvand M, Fazljou SMB, araj-Khodaei M, Baghervand Navid R

Chinese Medicine Research Hub

Review Article
Incorporating avocados into the Mediterranean diet may enhance its benefits, offering greater health flexibility and adaptability for non-Mediterranean residents.

2020 Frontiers in Nutrition The Forgotten Fruit: A Case for Consuming Avocado Within the Traditional Mediterranean Diet
Ford NA, Liu AG

Chinese Medicine Research Hub

Review Article
Ginger, through various methods, exhibits promising pain reduction effects for conditions such as dysmenorrhea, muscle soreness, osteoarthritis, low back pain, and migraines.

2020 Phytotherapy Research Clinical trials on pain lowering effect of ginger: A narrative review
Rondanelli M, Fossari F, Vecchio V, Gasparri C, Peroni G, Spadaccini D, Riva A, Petrangolini G, Iannello G, Nichetti M, Infantino V, Perna S

Chinese Medicine Research Hub

Experimental Study
Unpasteurised milk and dairy products intake could potentially alter gut microbiome composition which may influence psychological functioning.

2020 Nutrients Recipe for a Healthy Gut: Intake of Unpasteurised Milk Is Associated with Increased Lactobacillus Abundance in the Human Gut Microbiome
Butler MI, Bastiaanssen TFS, Long-Smith C, Berding K, Morkl S, Cusack AM, Strain C, Busca K, Porteous-Allen P, Claesson MJ, Stanton C, Cryan JF, Allen D, Dinan TG

Chinese Medicine Research Hub

Randomised Controlled Trial
Eating whole SunGold kiwifruits, both with and without skin, can significantly decrease gut inflammation and alleviate constipation for both healthy people and those with irritable bowel syndrome.

2020 Nutrients The Effects on Immune Function and Digestive Health of Consuming the Skin and Flesh of Zespri® SunGold Kiwifruit (Actinidia Chinensis var. Chinensis ‘Zesy002’) in Healthy and IBS-Constipated Individuals
Eady SL, Wallace AJ, Hedderley DI, Bentley-Hewitt KL, Butts CA

Chinese Medicine Research Hub

Systematic Review
Green coffee supplementation significantly decreases fasting blood sugar, insulin, and triglycerides while boosting high-density lipoprotein levels.

2020 Journal of Diabetes & Metabolic Disorders The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials
Morvaridi M, Rayyani E, Jaafari M, Khiabani A, Rahimlou M

Chinese Medicine Research Hub

Daily consumption of coffee and green tea is linked with decreased body mass index, body fat percentage, and cardiovascular risks in middle-aged Japanese women.

2020 Nutrients Daily Coffee and Green Tea Consumption Is Inversely Associated with Body Mass Index, Body Fat Percentage, and Cardio-Ankle Vascular Index in Middle-Aged Japanese Women: A Cross-Sectional Study
Yonekura Y, Terauchi M, Hirose A, Odai T, Kato K, Miyasaka N

Chinese Medicine Research Hub

Systematic Review
Coffee intake may have a variable effect on inflammation markers, with different responses noted between men and women and across various geographical regions.

2020 Nutrients Coffee Consumption and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis
Moua ED, Hu C, Day N, Hord NG, Takata Y

Chinese Medicine Research Hub

Systematic Review
Green tea intake can significantly reduce body weight, body mass index and waist circumference, with the greatest effect seen with lower dosages and shorter treatment durations.

2020 Phytotherapy Research The effect of green tea supplementation on obesity: A systematic review and dose–response meta‐analysis of randomized controlled trials
Lin Y, Shi D, Su B, Wei J, Găman MA, Sedanur Macit M, Borges do Nascimento IJ, Guimaraes NS

Chinese Medicine Research Hub

Experimental Study
Date palm fruit extract may mitigate some harmful effects of formaldehyde on male fertility by improving testosterone, sperm, and testicular conditions.

2020 International Journal of Reproductive BioMedicine (IJRM) The prophylactic effect of date palm (Phoenix dactylifera L.) fruit extract on testicular toxicity induced by formaldehyde: An experimental study
Zaren M, Haghpanah T, Asadi Shekari M, Hassan Eftekhar-Vaghefi S

Chinese Medicine Research Hub

Systematic Review
Aromatherapy, specifically with lavender essential oil, can effectively alleviate maternal anxiety and labor pain.

2020 Ethiopian Journal of Health Sciences The Effectiveness of Aromatherapy in the Management of Labor Pain and Anxiety: A Systematic Review
Mahbubeh Tabatabaeichehr , Hamed Mortazavi

Chinese Medicine Research Hub

Systematic Review
Almond intake significantly decreased diastolic blood pressure, and inconsistently, almonds decreased systolic blood pressure.

2020 Complementary Therapies in Medicine The effect of almond intake on blood pressure: A systematic review and meta-analysis of randomized controlled trials
Eslampour E, Asbaghi O, Hadi A, Abedi S, Ghaedi E, Lazaridi AV, Miraghajani M

Chinese Medicine Research Hub

Systematic Review
Cinnamon supplementation may help manage metabolic parameters in polycystic ovary syndrome patients by reducing fasting blood sugar, insulin, LDL-C, total cholesterol, and triacylglycerol levels.

2020 Journal of Ethnopharmacology Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis
Heydarpour F, Hemati N, Hadi A, Moradi S, Mohammadi E, Farzaei MH

Chinese Medicine Research Hub

Experimental Study
Pomegranate juice has potential beyond ascorbic acid alone in enhancing iron absorption and assimilation, supporting Ayurveda's proposition of managing iron deficiency anemia with pomegranate.

2020 Plant Foods for Human Nutrition Pomegranate Juice Enhances Iron Dialysability and Assimilation in In-Vitro Cell Free and Cell-Based Models
Balasubramani SP, Varghese RK, Vishnuprasad CN, Venkatasubramanian P

Chinese Medicine Research Hub

Systematic Review
Meta-analysis showed that date fruit consumption can significantly reduce the active phase of labor, and also significantly improve the bishop score.

2020 BMC Pregnancy and Childbirth Effects of date fruit (Phoenix dactylifera L.) on labor and delivery outcomes: a systematic review and meta-analysis
Bagherzadeh Karimi A, Elmi A, Mirghafourvand M, Baghervand Navid R

Chinese Medicine Research Hub

Systematic Review
Cinnamon supplementation can improve blood pressure by a modest degree.

2020 Clinical Nutrition ESPEN The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials
Hadi A, Campbell MS, Hassani B, Pourmasoumi M, Salehi-sahlabadi A, Hosseini SA

Chinese Medicine Research Hub

Review Article
Different varieties of dates pose impressive nutritional profiles and exhibit multiple health benefits, including anti-cancer, anti-inflammatory, and cholesterol lowering potential.

2020 Food Bioscience Nutritional and biological characteristics of the date palm fruit (Phoenix dactylifera L.) – A review
Hussain MI, Farooq M, Syed QA

Chinese Medicine Research Hub

Randomised Controlled Trial
Chamomile capsules can decrease the amount of menstrual bleeding and thus, can offer remedy for women suffering from heavy periods.

2020 Journal of Pharmacopuncture Do Chamomile effect on duration, amount of bleeding, and interval of menstrual cycles?
Mollabashi EN, Ziaie T, Bekhradi R, Khalesi ZB

Chinese Medicine Research Hub

Review Article
Pomegranate, due to its polyphenols, flavonoids and fatty acids, exhibits significant pain-relieving effects and could potentially be used as a treatment for various types of pain.

2020 Plants Pomegranate as a Potential Alternative of Pain Management: A Review
Guerrero-Solano JA, Jaramillo-Morales OA, Velázquez-González C, De la O-Arciniega M, Castañeda-Ovando A, Betanzos-Cabrera G, Bautista M

Chinese Medicine Research Hub

Randomised Controlled Trial
Daily intake of 3 grams of oat beta-glucans significantly reduces LDL-Cholesterol, Total Cholesterol, and non-HDL-Cholesterol levels without impacting intestinal well-being or glucose levels.

2020 Nutrients A Randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study
Cicero AFG, Fogacci F, Veronesi M, Strocchi E, Grandi E, Rizzoli E, Poli A, Marangoni F, Borghi C

Chinese Medicine Research Hub

Systematic Review
Green tea, containing antioxidative catechins, may possess some beneficial effects in reducing the risk of specific types of cancer.

2020 Cochrane Database of Systematic Reviews Green tea (Camellia sinensis) for the prevention of cancer
Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, Vinceti M

Chinese Medicine Research Hub

Randomised Controlled Trial
Certain essential oils such as lavender, neroli, jasmine, roman chamomile, clary sage, and Indian sandalwood can potentially increase oxytocin concentrations in postmenopausal women.

2020 The Journal of Alternative and Complementary Medicine The Effects of Essential Oil on Salivary Oxytocin Concentration in Postmenopausal Women
Tarumi W, Shinohara K

Chinese Medicine Research Hub

Systematic Review
Almond consumption was found to significantly reduce systolic blood pressure.

2020 Journal of King Saud University - Science The effect of almonds consumption on blood pressure: A systematic review and dose-response meta-analysis of randomized control trials
Li Z, Bhagavathula AS, Batavia M, Clark C, Abdulazeem HM, Rahmani J, Yin F

Chinese Medicine Research Hub

Meta-Analysis
Consumption of raw milk early in life appears to provide protection against asthma and allergies, regardless of whether children live on farms or in rural, non-farm areas.

2020 The Journal of Allergy and Clinical Immunology: In Practice The Beneficial Effect of Farm Milk Consumption on Asthma, Allergies, and Infections: From Meta-Analysis of Evidence to Clinical Trial
Brick T, Hettinga K, Kirchner B, Pfaffl MW, Ege MJ

Chinese Medicine Research Hub

Meta-Analysis
Pomegranate juice supplementation notably diminishes inflammation and vascular dysfunction markers in adults, offering potential cardiovascular health benefits.

2020 Complementary Therapies in Medicine The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review
Wang P, Zhang Q, Hou H, Liu Z, Wang L, Rasekhmagham R, Kord-Varkaneh H, Santos HO, Yao G

Chinese Medicine Research Hub

Systematic Review
Cinnamon supplementation in type 2 diabetes patients significantly reduces systolic and diastolic blood pressure, but doesn't significantly affect body weight and waist circumference.

2020 Diabetes & Metabolic Syndrome: Clinical Research & Reviews Effect of cinnamon supplementation on blood pressure and anthropometric parameters in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials
Jamali N, Jalali M, Saffari-Chaleshtori J, Samare-Najaf M, Samareh A

Chinese Medicine Research Hub

Systematic Review
Blueberries and their products may improve certain measures of cognitive performance, particularly memory, and positively affect mood.

2020 Brain, Behavior, and Immunity The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials
Travica N, D'Cunha NM, Naumovski N, Kent K, Mellor DD, Firth J, Georgousopoulou EN, Dean OM, Loughman A, Jacka F, Marx W

Chinese Medicine Research Hub

Systematic Review
Honey exhibits significant anti-Helicobacter pylori activity, with at least 10% concentration proving effective in inhibiting gastric and duodenal ulcers, highlighting its therapeutic potential.

2020 Sains Malaysiana In vitro Study of Anti-Helicobacter pylori Activity of Honey: A Systematic Review
Adam Q, Annuar F, Alfizah H, Mohd Fahami NA

Chinese Medicine Research Hub

Systematic Review
These reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases.

2020 Nutrients Beneficial Effects of Walnuts on Cognition and Brain Health
Chauhan A, Chauhan V.

Chinese Medicine Research Hub

Systematic Review
Green tea influences liver enzymes differently based on an individual's health status, reducing levels in patients with Nonalcoholic Fatty Liver Disease, but slightly increasing levels in healthy subjects.

2020 Phytotherapy Research Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials
Mahmoodi M, Hosseini R, Kazemi A, Ofori‐Asenso R, Mazidi M, Mazloomi SM

Chinese Medicine Research Hub

Meta-Analysis
Coffee consumption shows a strong association with decreased risk of liver and endometrial cancer.

2020 BMC Cancer Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies
Zhao LG, Li ZY, Feng GS, Ji XW, Tan YT, Li HL, Gunter MJ, Xiang YB

Chinese Medicine Research Hub

Experimental Study
Lactic acid bacteria strains isolated from indigenous Bangladeshi raw milk demonstrate strong probiotic potential and antimicrobial activity against various pathogens.

2020 Journal of Dairy Science Characterization and evaluation of lactic acid bacteria from indigenous raw milk for potential probiotic properties
Reuben RC, Roy PC, Sarkar SL, Rubayet Ul Alam ASM, Jahid IK

Chinese Medicine Research Hub

Clinical Study
Green tea intake can significantly reduce both systolic and diastolic blood pressure.

2020 Medicine Effect of green tea supplementation on blood pressure
Xu R, Yang K, Ding J, Chen G

Chinese Medicine Research Hub

Randomised Controlled Trial
Daily avocado consumption improves attentional inhibition and increases serum lutein concentrations, irrespective of changes in lutein status, in adults with obesity.

2020 International Journal of Psychophysiology Effects of 12-week avocado consumption on cognitive function among adults with overweight and obesity
Edwards CG, Walk AM, Thompson SV, Reeser GE, Erdman JW, Burd NA, Holscher HD, Khan NA

Chinese Medicine Research Hub

Randomised Controlled Trial
Intranasal application of essential oils such as lavender and fennel (Pinetonina™) significantly lowers cortisol levels and improves sleep quality.

2020 European Journal of Integrative Medicine Intranasal use of lavender and fennel decreases salivary cortisol levels and improves quality of sleep: A double-blind randomized clinical trial
Polonini H, Mesquita D, Lanine J, Dijkers E, Gkinis S, Raposo NRB, Brandão MAF, Ferreira AO

Chinese Medicine Research Hub

Systematic Review
Ginger has been effective in a majority of studies, including those that examined the alleviation of nausea and vomiting of pregnancy, digestive function, improvement in the expression level of markers for colorectal cancer risk, and anti-inflammatory functions.

2020 Nutrients Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials
Anh NH, Kim SJ, Long NP, Min JE, Yoon YC, Lee EG, Kim M, Kim TJ, Yang YY, Son EY, Yoon SJ, Diem NC, Kim HM, Kwon SW.

Chinese Medicine Research Hub

Review Article
Bioactive compounds found in avocado waste products exhibit various biological properties, with potential applications in the food and pharmaceutical industries.

2020 Food Reviews International Pulp, Leaf, Peel and Seed of Avocado Fruit: A Review of Bioactive Compounds and Healthy Benefits
Jimenez P, Garcia P, Quitral V, Vasquez K, Parra-Ruiz C, Reyes-Farias M, Garcia-Diaz DF, Robert P, Encina C, Soto-Covasich J

Chinese Medicine Research Hub

Clinical Study
Children with asthma, aged between 2 and 18, were found to be significantly shorter than their healthy counterparts.

2020 Journal of Pharmaceutical Research International Efficacy of Matricaria chamomilla L. in Infantile Colic: A Double Blind, Placebo Controlled Randomized Trial
Mohamadi Sorme F, Tabarra M, Alimadady H, Rahimi R, Sepidarkish M, Karimi M

Chinese Medicine Research Hub

Randomised Controlled Trial
The combination of ginger and chamomile was as effective as mefenamic acid in managing dysmenorrhea pain and more efficient in reducing related symptoms.

2020 Complementary Medicine journal Evaluation of the Synergism of Medicinal Effects of Chamomile and Ginger on Pain and Symptoms of Primary Dysmenorrhea: A Randomized Controlled Trial
Shabani F, Zareian MA

Chinese Medicine Research Hub

Cohort Study
Regular consumption of raw carrots, specifically 2-4 or more per week, is associated with a decreased risk of colorectal cancer.

2020 Nutrients Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes
Deding U, Baatrup G, Christensen LP, Kobaek-Larsen M

Chinese Medicine Research Hub

Network Pharmacology
Ganpu tea, derived from Pu-erh tea and the pericarp of Chachi, enhances antioxidant capacities and modulates gut microbiota beneficially more than Pu-erh tea alone.

2020 Nutrients Chemical Profile, Antioxidative, and Gut Microbiota Modulatory Properties of Ganpu Tea: A Derivative of Pu-erh Tea
Zheng Y, Zeng X, Chen T, Peng W, Su W

Chinese Medicine Research Hub

Experimental Study
Chrysanthemum morifolium, Naringenin and Apigenin can alleviate depression-like behavior by interfering with specific metabolic pathways.

2020 Artificial Cells, Nanomedicine, and Biotechnology A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium
Liu T, Zhou N, Xu R, Cao Y, Zhang Y, Liu Z, Zheng X, Feng W

Chinese Medicine Research Hub

Network Pharmacology
Pomegranate fruit extract significantly enhances cartilage gene expression and chondrogenesis in human adipose-derived stem cells compared to Avocado/Soybean Unsaponifiable.

2020 Research in Pharmaceutical Sciences Chondrogenic activity of two herbal products; pomegranate fruit extract and avocado/soybean unsaponifiable
Bahramian H, Teimourinejad A, Hashemibeni B, Salehi H, Mostafavi FS, Kazemi M

Chinese Medicine Research Hub

Systematic Review
Cocoa consumption significantly reduces markers of oxidative stress in the adult population, affirming its important role in the human metabolic pathway.

2020 Complementary Therapies in Medicine The effect of cocoa consumption on markers of oxidative stress: A systematic review and meta-analysis of interventional studies
Mehrabani S, Arab A, Mohammadi H, Amani R

Chinese Medicine Research Hub

Systematic Review
Almond intake significantly reduces body weight and fat mass in adults, yet it does not impact body mass index, waist circumference, or fat-free mass.

2020 Food & Function The effect of almond intake on anthropometric indices: a systematic review and meta-analysis
Eslampour E, Moodi V, Asbaghi O, Ghaedi E, Shirinbakhshmasoleh M, Hadi A, Miraghajani M

Chinese Medicine Research Hub

Review Article
Prunus mume fruit extracts display hepatoprotective, anti-inflammatory, antioxidative, antibacterial effects, and show promise for treating cancer and alleviating chemotherapy side-effects.

2020 Journal of Ethnopharmacology Anticancer properties of Prunus mume extracts (Chinese plum, Japanese apricot)
Bailly C

Chinese Medicine Research Hub

Review Article
Saffron shows potential as a promising therapeutic agent in treating neurodegenerative ocular diseases.

2020 Neural Regeneration Research Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases
Ramírez JM, Salazar JJ, Fernández-Albarral JA, de Hoz R, Ramírez AI, López-Cuenca I, Salobrar-García E, Pinazo-Durán MD

Chinese Medicine Research Hub

Systematic Review
Cinnamon intake significantly reduces body weight, body mass index, waist circumference, and fat mass in adults, and can be recommended as a supplement for obesity management.

2020 Clinical Nutrition Cinnamon supplementation positively affects obesity: A systematic review and dose-response meta-analysis of randomized controlled trials
Mousavi SM, Rahmani J, Kord-Varkaneh H, Sheikhi A, Larijani B, Esmaillzadeh A

Chinese Medicine Research Hub

Review Article
The date fruit contains compounds such as flavonoids that can protect tissues from harm and reduce risks of illnesses like cardiovascular disease and cancer.

2020 International Review of Neurobiology Date palm fruit (Phoenix dactylifera): Nutritional values and potential benefits on health
Bentrad N, Hamida-Ferhat A

Chinese Medicine Research Hub

Review Article
Peppermint's extensive applications, especially its antimicrobial and antioxidant features, and potential health benefits can significantly increase its market value in various industries.

2020 Journal of Pharmacognosy and Phytochemistry Peppermint a medicinal herb and treasure of health: A review
Parv Nayak, Tankesh Kumar, AK Gupta and NU Joshi

Chinese Medicine Research Hub

Review Article
Coffee and decaffeinated coffee appear to provide long-term protection against developing type 2 diabetes, potentially due to the influence of chlorogenic acids.

2020 Food & Function Protection against developing type 2 diabetes by coffee consumption: assessment of the role of chlorogenic acid and metabolites on glycaemic responses
Williamson G

Chinese Medicine Research Hub

Review Article
Avocado, particularly the Hass variety, has substantial health benefits due to its rich contents of nutrients, fiber, and bioactive constituents including antioxidants.

2020 Antioxidants in Fruits: Properties and Health Benefits Avocado
Majid D, Dar BN, Parveen S, Jabeen A, Allai FM, Sofi SA, Ganaie TA

Chinese Medicine Research Hub

Randomised Controlled Trial
Consuming walnuts daily can reduce cardiovascular risk factors in chronic kidney disease patients without altering significant physiological levels.

2019 Nutrients A Pilot Randomized Crossover Trial Assessing the Safety and Short-Term Effects of Walnut Consumption by Patients with Chronic Kidney Disease
Sanchis P, Molina M, Berga F, Muñoz E, Fortuny R, Costa-Bauzá A, Grases F, Buades JM

Chinese Medicine Research Hub

Pomegranate juice can reduce melatonin, increase insulin levels, and improve insulin resistance in individuals with impaired fasting glucose.

2019 Food Science & Nutrition Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose
Banihani SA, Fashtaky RA, Makahleh SM, El‐Akawi ZJ, Khabour OF, Saadeh NA

Chinese Medicine Research Hub

Systematic Review
Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products.

2019 Evidence-Based Complementary and Alternative Medicine Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review
Chen PE, Liu CY, Chien WH, Chien CW, Tung TH

Chinese Medicine Research Hub

Review Article
Traditional Chinese medicine, especially Zuo Gui Wan, red raspberry leaves, and Orthosiphon stamineus, seems to control gestational diabetes effectively without reported toxicity.

2019 Journal of Diabetes Research Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus
Xu YXZ, Xi S, Qian X

Chinese Medicine Research Hub

Clinical Study
Drinking at least 1.5 to 2 litres of bicarbonate-rich mineral water daily significantly reduces dietary acid load in healthy adults.

2019 Food & Nutrition Research Effects of mineral waters on acid–base status in healthy adults: results of a randomized trial
Wasserfurth P, Schneider I, Ströhle A, Nebl J, Bitterlich N, Hahn A

Chinese Medicine Research Hub

Review Article
The Mediterranean diet, especially the high consumption of extra-virgin olive oil, significantly reduces the risks of vascular diseases and Alzheimer's.

2019 Revue Neurologique Extra-virgin olive oil for potential prevention of Alzheimer disease
Román GC, Jackson RE, Reis J, Román AN, Toledo JB, Toledo E

Chinese Medicine Research Hub

Systematic Review
Cinnamon supplementation can significantly reduce body weight, body mass index, and waist-hip ratio.

2019 Phytotherapy Research Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta-analysis of controlled clinical trials
Zeinab Yazdanpanah,Maryam Azadi-Yazdi,Hadis Hooshmandi,Nahid Ramezani-Jolfaie,Amin Salehi-Abargouei,

Chinese Medicine Research Hub

Experimental Study
Pu-erh tea's ability to lower blood pressure is primarily due to theabrownins and caffeine, which cause vasodilation irrespective of the endothelium.

2019 Frontiers in Pharmacology Pu-Erh Tea Relaxes the Thoracic Aorta of Rats by Reducing Intracellular Calcium
Luo Dan, Chen Xuejiao, Zhu Xu, Liu Shuang, Li Jie, Xu Jianping, Zhao Jinhua, Ji Xu

Chinese Medicine Research Hub

Theoretical Article
Consumption of oat β-glucan may lower cholesterol and risk of cardiovascular disease by altering gut bacteria and their effects on bile acid and cholesterol metabolism.

2019 Frontiers in Nutrition The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome
Joyce SA, Kamil A, Fleige L, Gahan CGM

Chinese Medicine Research Hub

Coix lacryma-jobi sprout extract effectively inhibits cervical cancer cell growth by triggering cell cycle arrest and apoptosis.

2019 BMC Complementary Medicine and Therapies Coix lacryma-jobi var. ma-yuen Stapf sprout extract induces cell cycle arrest and apoptosis in human cervical carcinoma cells
Son, E.S., Kim, SH., Kim, Y.O. et al

Chinese Medicine Research Hub

Systematic Review
A combination of peppermint oil and caraway oil is an effective and safe short-term treatment for functional dyspepsia.

2019 Evidence-Based Complementary and Alternative Medicine A Combination of Peppermint Oil and Caraway Oil for the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis
Juanjuan Li, Lin Lv, Jiaqi Zhang, Lin Xu, Enjin Zeng, Zedan Zhang, Fengyun Wang, Xudong Tang

Chinese Medicine Research Hub

Coix seed extract could augment the efficacy of gemcitabine therapy in pancreatic cancer cells at least partly due to the alteration of ABC transporter-mediated drug efflux function.

2019 International Journal of Molecular Sciences Coix Seed Extract Enhances the Anti-Pancreatic Cancer Efficacy of Gemcitabine through Regulating ABCB1- and ABCG2-Mediated Drug Efflux: A Bioluminescent Pharmacokinetic and Pharmacodynamic Study
Qian, Y.; Xiong, Y.; Feng, D.; Wu, Y.; Zhang, X.; Chen, L.; Gu, M.

Chinese Medicine Research Hub

Systematic Review
Cinnamon supplementation leads to a significant reduction in both systolic and diastolic blood pressure in adults.

2019 Critical Reviews in Food Science and Nutrition Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials
Seyed Mohammad Mousavi, Ahmad Jayedi, Yahya Jalilpiran, Maryam Hajishafiee, Azadeh Aminianfar, Ahmad Esmaillzadeh.

Chinese Medicine Research Hub

Systematic Review
Peppermint oil significantly reduces colonic spasm during colonoscopy, but does not affect the adenoma detection rate or cecal intubation time.

2019 The American Journal of Gastroenterology Peppermint Oil Decreases Colonic Spasm Without Significantly Affecting Cecal Intubation Time and Adenoma Detection Rate: A Systematic Review and Meta-Analysis
Nehme, Fredy; Al Momani, Laith; Alomari, Mohammad ; Zafar, Yousaf

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A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.

2024 International Journal of Biological Macromolecules Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis Peng G, Wang S, Zhang H, Xie F, Jiao L, Yuan Y, et al.

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Pomegranate extract could potentially benefit women's reproductive health, enhance fertility, regulate menstrual cycles, support pregnancy, and help treat polycystic ovary syndrome.

2024 Life Therapeutic Potential of Pomegranate Extract for Women’s Reproductive Health and Breast Cancer Jang JY, Kim D, Im E, Kim ND

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Manuka honey has demonstrated the potential to inhibit the proliferation of human breast cancer cells and stimulate apoptosis in these cells.

2024 Nutrients Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models Márquez-Garbán DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, et al.

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Greater intake of blueberries considerably decreases the risk of age-related macular degeneration, while a remarkable dietary intake of anthocyanins inversely correlates with cataract incidents.

2024 The Journal of Nutrition Intake of Blueberries, Anthocyanins, and Risk of Eye Disease in Women Sesso HD, Rautiainen S, Park SJ, Kim E, Lee IM, Glynn RJ, et al.

Cohort Study Age-Related Macular Degeneration Anthocyanins Blueberry

Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues.

2024 Food Science & Nutrition The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis Heydarian A, Tahvilian N, Asbaghi O, Cheshmeh S, Nadery M, Aryaeian N

Systematic Review Cholesterol LDL Plum

Review Articles

The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis

Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies

A Comprehensive Review on Therapeutic Properties of Lotus Seeds

Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review

Carrot intake is consistently negatively associated with cancer incidence: A systematic review and meta-analysis of prospective observational studies

Clinical Trials

A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome. An exploratory analysis

Effects of an Unripe Avocado Extract on Glycaemic Control in Individuals with Obesity: A Double-Blinded, Parallel, Randomised Clinical Trial

A 4-Week Pecan-Enriched Diet Improves Postprandial Lipid Peroxidation in Aging Adults

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial

Study Protocols

Presentation Slides

Animal Study A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.

Pomegranate extract could potentially benefit women's reproductive health, enhance fertility, regulate menstrual cycles, support pregnancy, and help treat polycystic ovary syndrome.

Animal Study Manuka honey has demonstrated the potential to inhibit the proliferation of human breast cancer cells and stimulate apoptosis in these cells.

Cohort Study Greater intake of blueberries considerably decreases the risk of age-related macular degeneration, while a remarkable dietary intake of anthocyanins inversely correlates with cataract incidents.

Systematic Review Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues.

Review Article Lemongrass essential oil can effectively treat periodontitis, gingivitis, oral malodour, skin aging, and dandruff, and it is comparable to certain established treatments.

Data Mining The traditional Chinese medicine prescription combination of Chrysanthemi Flos, Cassiae Semen, Lycii Fructus, Angelicae Sinensis Radix and Salviae Miltiorrhizae Radix et Rhizoma presents potential for treating retinal diseases.

Meta-Analysis Consuming carrots can significantly decrease the risk of cancer.

Systematic Review Pomegranate fruit and its phytochemicals may offer a novel, natural alternative for the treatment of pathological anxiety, with fewer adverse effects than traditional medications.

Randomised Controlled Trial Changes in gut microbiome associated with a low-fat, vegan diet and cooked soybeans may reduce the frequency and severity of postmenopausal hot flashes.

Experimental Study The compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside from chrysanthemum flowers demonstrated superior antioxidant and anti-osteoporosis effects.

Randomised Controlled Trial Consumption of unripe avocado extract in the diet may lower postprandial insulin levels in overweight adults with previously elevated insulin levels.

Systematic Review Pomegranate can significantly enhance women's health during and after menopause by reducing hot flashes severity and other menopause symptoms.

Review Article Almond consumption has beneficial impacts on cardiovascular diseases, diabetes, obesity, and it can improve cognitive performance and protect against skin aging.

Review Article Fruits, especially kiwifruits, and rye bread can enhance bowel movements and help manage chronic constipation better than conventional dietary methods.

Cohort Study Long-term consumption of green tea can potentially lessen the risk of depression in postmenopausal women by decreasing inflammation and boosting estradiol levels.

Clinical Study Consuming bicarbonate-calcium mineral water, low in sodium, can help manage calcium imbalance and support bone health in perimenopausal women.

Animal Study A combination of soybean germ extract and a probiotic significantly improved menopause-related conditions and mood in an ovariectomized rat model.

Experimental Study Phenolic extracts from turmeric and ginger have significant anti-inflammatory effects and enhance wound healing in Wistar rats.

Network Pharmacology The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.

Cohort Study Avocado consumption is linked to better glucose regulation, with metabolomic biomarkers of avocado intake showing even stronger associations with lower glycemia.

Review Article Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.

Randomised Controlled Trial A beverage formula containing fish roe, snow fungus, and yeast enhances cognitive function by improving memory, response times, and emotional recognition, while reducing anxiety and fatigue.

Randomised Controlled Trial Daily consumption of pecans for a month can help protect against post-meal oxidative stress in aging adults.

Experimental Study Lycium barbarum polysaccharide may decrease apoptosis in retinal photoreceptor cells of retinitis pigmentosa mice by suppressing nuclear factor-kappa B/NOD-like receptor thermal protein domain-associated protein 3 pathway.

Animal Study Fermented Pueraria lobata root extract and Glycine max extract showed estrogen-like activities, reducing depressive symptoms in menopausal mice but not increasing female cancer risks.

Review Article Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.

Systematic Review Pomegranate consumption positively affects triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels.

Animal Study
A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.

Animal Study
Manuka honey has demonstrated the potential to inhibit the proliferation of human breast cancer cells and stimulate apoptosis in these cells.

Cohort Study
Greater intake of blueberries considerably decreases the risk of age-related macular degeneration, while a remarkable dietary intake of anthocyanins inversely correlates with cataract incidents.

Systematic Review
Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues.

Review Article
Lemongrass essential oil can effectively treat periodontitis, gingivitis, oral malodour, skin aging, and dandruff, and it is comparable to certain established treatments.

Data Mining
The traditional Chinese medicine prescription combination of Chrysanthemi Flos, Cassiae Semen, Lycii Fructus, Angelicae Sinensis Radix and Salviae Miltiorrhizae Radix et Rhizoma presents potential for treating retinal diseases.

Meta-Analysis
Consuming carrots can significantly decrease the risk of cancer.

Systematic Review
Pomegranate fruit and its phytochemicals may offer a novel, natural alternative for the treatment of pathological anxiety, with fewer adverse effects than traditional medications.

Randomised Controlled Trial
Changes in gut microbiome associated with a low-fat, vegan diet and cooked soybeans may reduce the frequency and severity of postmenopausal hot flashes.

Experimental Study
The compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside from chrysanthemum flowers demonstrated superior antioxidant and anti-osteoporosis effects.

Randomised Controlled Trial
Consumption of unripe avocado extract in the diet may lower postprandial insulin levels in overweight adults with previously elevated insulin levels.

Systematic Review
Pomegranate can significantly enhance women's health during and after menopause by reducing hot flashes severity and other menopause symptoms.

Review Article
Almond consumption has beneficial impacts on cardiovascular diseases, diabetes, obesity, and it can improve cognitive performance and protect against skin aging.

Review Article
Fruits, especially kiwifruits, and rye bread can enhance bowel movements and help manage chronic constipation better than conventional dietary methods.

Cohort Study
Long-term consumption of green tea can potentially lessen the risk of depression in postmenopausal women by decreasing inflammation and boosting estradiol levels.

Clinical Study
Consuming bicarbonate-calcium mineral water, low in sodium, can help manage calcium imbalance and support bone health in perimenopausal women.

Animal Study
A combination of soybean germ extract and a probiotic significantly improved menopause-related conditions and mood in an ovariectomized rat model.

Experimental Study
Phenolic extracts from turmeric and ginger have significant anti-inflammatory effects and enhance wound healing in Wistar rats.

Network Pharmacology
The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.

Cohort Study
Avocado consumption is linked to better glucose regulation, with metabolomic biomarkers of avocado intake showing even stronger associations with lower glycemia.

Review Article
Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.

Randomised Controlled Trial
A beverage formula containing fish roe, snow fungus, and yeast enhances cognitive function by improving memory, response times, and emotional recognition, while reducing anxiety and fatigue.

Randomised Controlled Trial
Daily consumption of pecans for a month can help protect against post-meal oxidative stress in aging adults.

Experimental Study
Lycium barbarum polysaccharide may decrease apoptosis in retinal photoreceptor cells of retinitis pigmentosa mice by suppressing nuclear factor-kappa B/NOD-like receptor thermal protein domain-associated protein 3 pathway.

Animal Study
Fermented Pueraria lobata root extract and Glycine max extract showed estrogen-like activities, reducing depressive symptoms in menopausal mice but not increasing female cancer risks.

Review Article
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.

Systematic Review
Pomegranate consumption positively affects triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels.

Review Article
Soybean intake can potentially reduce risks of several cancers, type 2 diabetes, osteoporosis, and hot flashes, and it may negatively impact some drug treatments and cause allergies.

Review Article
Plums, which are rich in bioactive compounds, antioxidants, and vitamins, can help maintain blood glucose level, bone health, heart health and even treat certain cancers.

Network Pharmacology
The compounds apocarotenoids and carotenoids found in saffron extract could potentially interact with multiple targets, helping to manage the symptoms of polycystic ovary syndrome.

Experimental Study
Moderate consumption of blueberries may effectively reduce bone loss in healthy postmenopausal women.

Meta-Analysis
Blueberry consumption significantly improves two-back test accuracy, suggesting potential cognitive benefits.

Network Pharmacology
Gold kiwifruit extracts contained different bioactive materials which showed selective cytotoxic activity against human oral tumor cells and displayed anti-HIV, antioxidant, and antibacterial activities.

Experimental Study
The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.

Review Article
The Mediterranean diet and reduced intake of trans fatty acids, saturated fatty acids, and discretionary foods like fast food and sugar-sweetened beverages may improve fertility rates.

Systematic Review
Natural calcium-rich mineral waters offer a bioavailable calcium source, beneficial for bone health, cardiovascular function, weight management, and overall well-being.

Systematic Review
There is evidence to support significant improvements to total sleep time and sleep efficiency with the ingestion of tart cherries.

Review Article
Honey intake has observed beneficial effects on various health aspects like cardiovascular, metabolic risk factors, and wound healing, primarily replacing other sweeteners.

Animal Study
Jin Si Huang Ju tea, a traditional Chinese beverage, contains compounds that potentially reduce lipids, mitigate insulin resistance and reduce liver inflammation in vitro.

Systematic Review
Oat consumption can significantly improve lipid profiles, particularly reducing total cholesterol and LDL cholesterol, with potential positive effects on triglycerides and HDL cholesterol under certain conditions.

Review Article
Nutrition, particularly an anti-inflammatory Mediterranean diet supplemented with oily fish and omega-3 supplements, can potentially reduce inflammation and improve symptoms of rheumatoid arthritis.

Review Article
Crocin, a compound derived from saffron, has shown considerable potential in hindering tumor growth and improving immune status, across various malignant tumors.

Review Article
Pomegranate and its components could offer considerable potential as dietary supplements or supports in treatment for cardiovascular and non-cardiovascular diseases.

Systematic Review
Vitamin D supplementation significantly reduces pain levels in people suffering from primary dysmenorrhea.

Review Article
Eating apples and apple products can enhance health by protecting the cardiovascular system, combating cancer and cognitive impairment, and improving hair growth, among other beneficial effects.

Experimental Study
Zhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties.

Experimental Study
Bee-collected pollen and bee bread, particularly when artificially fermented, demonstrate significant antiviral activity against the H1N1 strain of the influenza A virus.

Clinical Study
Consuming two medium-sized green kiwifruits an hour before bed can improve sleep quality and recovery stress balance among elite athletes.

Review Article
Berry fruits such as blueberries, cranberries, raspberries, and strawberries could potentially improve gut microbiota and reverse dysbiosis in chronic kidney disease patients.

Systematic Review
Saffron shows promising improvements in dealing with women's health issues related to labor, childbirth, premenstrual syndrome and menopause.

Systematic Review
Honey dressing significantly promotes healing and reduces recovery time in managing diabetic foot ulcers.

Systematic Review
Consumption of natural mineral water increases diuresis in both humans and animals, evident sometimes after just one intake.

Review Article
Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases.

Experimental Study
The anthocyanins from the Gardenblue variety of blueberries exhibit strong antiproliferative effects on various cancer cells, especially liver cancer cells.

Case Report
The combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.

Clinical Study
Consuming a honey-based gel, such as 'Bear Strength honey gel,' led to a notable reduction in diastolic and mean arterial blood pressure, with gender-specific improvements in redox status among healthy adults.

Review Article
Green tea helps alleviate symptoms in multiple benign gynecological disorders, primarily due to a compound called Epigallocatechin-3-gallate.

Randomised Controlled Trial
Consumption of fresh or dried kiwifruit in the evening improves aspects of sleep quality and mood, potentially mediated through changes in serotonin metabolism.

Systematic Review
Our dose-response analysis indicated that moderate green tea consumption (500–1000 mL/d) was associated with a 21% to 24% lower risk of stroke.

Systematic Review
Almond consumption can significantly reduce the serum concentration of the inflammatory mediator, Interleukin-6, in adults but no significant effect is found on C-reactive protein.

Clinical Study
Preclinical studies related to osteoporosis have reported favorable effects of honey on cortical and trabecular bone microstructure, bone strength, and oxidative stress.

Clinical Study
Clinical studies related to breast cancer have revealed that honey is effective in increasing blood cell counts, interleukin-3 levels, and quality of life.

Cohort Study
Ginger consumption could counteract the negative influence of disgust, induced by sexual body fluids, on sexual arousal in individuals.

Experimental Study
Chrysanthemum morifolium contains natural bioactive compounds, including 29 types of phenolics, which display significant antioxidant activity.

Review Article
Oats, in various edible forms, can regulate appetite hormones, aid weight management, strengthen the immune system, and contribute to gut health, making them effective for obesity management.

Review Article
Australian native plums contain phytochemicals that exhibit health benefits such as cardiovascular and liver protection.

Animal Study
Kiwifruit polysaccharides may alleviate the toxic effects of acrylamide by improving gut health and enhancing bile acid metabolism.

Systematic Review
Saffron supplementation significantly decreased oxidative stress markers and has beneficial effects in reducing oxidative stress.

Randomised Controlled Trial
Bicarbonate-rich mineral water “Staatl. Fachingen STILL” significantly reduces heartburn more effectively than placebo, improving patients’ quality of life.

Cohort Study
Regular consumption of raw carrots is associated with a significant, dose-dependent reduction in lung cancer incidence, suggesting a potential cancer-protective effect attributed to polyacetylenic compounds, particularly falcarinol and falcarindiol, present in raw carrots.

Clinical Study
Avocado consumption correlates with a wider variety of healthier food choices, offering potential benefits for weight control strategies.

Randomised Controlled Trial
Pomegranate extract supplements can help improve clinical symptoms and lower blood cell counts associated with inflammation in patients with allergic asthma.

Randomised Controlled Trial
Pomegranate juice supplementation has been found to effectively decrease testosterone levels in overweight and obese women diagnosed with polycystic ovary syndrome.

Review Article
Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.

Review Article
Honey exhibits multifaceted benefits for brain health, acting as a memory booster, neuroprotective agent, anti-stress, and anti-nociceptive substance, fostering potential therapeutic applications to enhance overall cognitive well-being.

Randomised Controlled Trial
The combination of dark chocolate with herbs could be one of the therapies for period pain.

Cohort Study
Heavy coffee consumption increases the risk of cardiovascular disease mortality in individuals with severe hypertension, while green tea consumption does not.

Animal Study
Specific fractions of Lycium barbarum, commonly known as Goji berry, reduce heart and kidney damage caused by anthracyclines while possibly enhancing their therapeutic effects.

Cohort Study
Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency.

Clinical Study
Chrysanthemum extract can be utilised as a natural ingredient to lessen post-meal cholesterol levels and enhance antioxidant status, after eating a high-fat meal.