Da Huang

Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the “General (Jiang Jun)” in Chinese medical herb

2020 Jul   Biomedicine & Pharmacotherapy   Zhuang T, Gu X, Zhou N, Ding L, Yang L, Zhou M

The present researches have identified that Rhubarb, as a traditional Chinese medicine, plays a protective role in the liver, but sometimes it also induces hepatotoxicity. The recent data regarding the mechanisms on hepatoprotection and hepatotoxicity of Rhubarb were explained with potential links between them explored, hoping to provide recommendations for the better usage in clinical practice. At present, the long-term clinical surveillance and clinical investigations on the hepatotoxicity of Rhubarb are still insufficient.

Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study

2018 Oct 01   Frontiers in Pharmacology   Huang KC, Su YC, Sun MF, Huang ST

Identification of the absorbed components and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma by ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry

2015 Jul   Journal of Pharmaceutical and Biomedical Analysis   Zhu H, Bi K, Han F, Guan J, Zhang X, Mao X, et al.

A total of 43 compounds, including 21 prototype compounds and 22 metabolites were detected and tentatively identified. Result indicated iridoid glycosides, anthraquinones, flavanones and their related metabolites were major constituents in rat plasma.