Gan Mai Da Zao Tang
Recent Insights
The traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
Depression Gan Cao Gan Mai Da Zao Tang
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
Gan Cao Gan Cao Da Zao Tang Gan Mai Da Zao Tang
Gan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
Anxiety GABA GABA system
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models
2022 Jan 19 Plants Li YX, Cheng KC, Hsu CT, Cheng JT, Yang TT
Animal Study Depression Serotonin Gan Cao Gan Mai Da Zao TangThe traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data
2021 Aug Complementary Therapies in Medicine Coyle ME, Liu J, Yang H, Wang K, Zhang AL, Guo X, et al.
Experimental Study Systematic Review Licorice Menopause Gan Cao Da Zao Tang Gan Mai Da Zao Tang Gan CaoThe Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
Spirit-Quieting Traditional Chinese Medicine may Improve Survival in Prostate Cancer Patients with Depression
2019 Feb 08 Journal of Clinical Medicine Lin PH, Lin SK, Hsu RJ, Pang ST, Chuang CK, Chang YH, et al.
TCM for depression was associated with a significantly lower risk of overall mortality compared to no TCM. Therefore, TCM for depression may have a positive association with the survival of prostate cancer patients with depression.
Cohort Study Jia Wei Xiao Yao San Chai Hu Jia Long Gu Mu Li Tang Prostate Cancer Depression Gan Mai Da Zao TangGABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction
2019 Jan 22 Frontiers in Neuroscience Chen HS, Gu LJ, Yang YX, Guo JY
Animal Study Gan Mai Da Zao Tang Anxiety GABA system Serotonin GABAGan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
Herbal medicine (Gan Mai Da Zao decoction) for depression: A systematic review and meta-analysis of randomized controlled trials
2014 Dec Maturitas Jun JH, Choi TY, Lee JA, Yun KJ, Lee MS
In summary, our systematic review and meta-analysis failed to provide evidence of the superiority of GMDZ decoction over anti-depressant therapies for major depression, post-surgical depression, or depression in the elderly, although there was evidence of an effect in post-stroke depression.
Systematic Review Meta-Analysis Gan Mai Da Zao TangResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
2022 Plants Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models Li YX, Cheng KC, Hsu CT, Cheng JT, Yang TT
Animal Study Depression Gan Cao Serotonin
This study experimentally examined the antidepressant impacts of Gan-Mai-Da-Zao (GMDZ), a Chinese traditional medicine that contains blighted wheat, licorice, and jujube. The researchers used an unpredictable chronic mild stress model in rats, some of whom received an injection with p-chlorophenylalanine to generate a chemical model for depression. The investigators employed behavioral tests, including forced swim tests, open field tests, and sucrose preference tests, to evaluate the chronic influence of GMDZ.
The oral application of GMDZ over 21 days considerably eased depressive behaviors in rats induced by either the unpredictable chronic mild stress or p-chlorophenylalanine. The treatment increased the expression of the serotonin transporter and brain-derived neurotrophic factor in the hippocampus in the rats with depression. However, rats provided with a similar herbal mixture that did not include licorice showed a significantly worse response, suggesting that licorice may play an essential role in the efficacy of GMDZ in combatting depression-like behaviors.
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
2021 Complementary Therapies in Medicine Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data Coyle ME, Liu J, Yang H, Wang K, Zhang AL, Guo X, et al.
Experimental Study Gan Cao Gan Cao Da Zao Tang Licorice
The methodology of this study involved exploring classical Chinese medicine textbooks to find the most frequent herbal mix used for symptoms similar to menopause. The approach taken was to sort and identify the formulas from the Encyclopedia of Traditional Chinese Medicine, a comprehensive resource in this field. Following this, a thorough review of randomized controlled trials was performed in order to determine the efficacy of the most common formula.
In terms of results, it was discovered that the Licorice and Jujube formula (LJF) was the most commonly found, mentioned in 36% of the analyzed references. The review of controlled trials revealed that the LJF might be effectively utilized for the improvement of sleep-related symptoms. Additionally, experimental studies hinted at potential benefits of the LJF, including sedative, antidepressant-like, estrogenic, and antiprogestogenic effects.
Gan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
2019 Frontiers in Neuroscience GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction Chen HS, Gu LJ, Yang YX, Guo JY
Animal Study Anxiety GABA GABA system
The mice were given the Gan-Mai-Da-Zao (GMDZ) decoction orally at different concentrations for a week, with Diazepam and Buspirone serving as positive controls. Anxiety-level testing was conducted using a combination of the elevated plus-maze, light/dark box, marble burying, open field, and rota-rod tests, providing a comprehensive assessment of the decoction's effects on mice.
Furthermore, the anxiolytic effects that GMDZ induced in the mice were challenged by the application of Flumazenil, a gamma-aminobutyric acid-A receptor antagonist, and WAY-100635, a serotonin-1A receptor antagonist. They found that the effects were successfully inhibited, indicating that the mechanism of action of GMDZ could be linked to both the serotonin and gamma-aminobutyric acid receptors in the nervous system, thereby reducing anxiety-like behavior in mice.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data
2021 Aug Complementary Therapies in Medicine Coyle ME, Liu J, Yang H, Wang K, Zhang AL, Guo X, et al.
Experimental Study Systematic Review Licorice Menopause Gan Cao Da Zao Tang Gan Mai Da Zao Tang Gan CaoThe Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
Herbal medicine (Gan Mai Da Zao decoction) for depression: A systematic review and meta-analysis of randomized controlled trials
2014 Dec Maturitas Jun JH, Choi TY, Lee JA, Yun KJ, Lee MS
In summary, our systematic review and meta-analysis failed to provide evidence of the superiority of GMDZ decoction over anti-depressant therapies for major depression, post-surgical depression, or depression in the elderly, although there was evidence of an effect in post-stroke depression.
Systematic Review Meta-Analysis Gan Mai Da Zao TangPresentation Slides
The traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
Gan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
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