Huang Lian

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Chinese Medicine Research Hub

Systematic Review

Berberine's potential similarity to metformin in addressing glycolipid metabolism and insulin sensitivity, and exploring promising combinations involving berberine, metformin, and cyproterone acetate for treating polycystic ovary syndrome with insulin resistance.

2018 Evidence-Based Complementary and Alternative Medicine The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review
Meng-Fei Li, Xiao-Meng Zhou, Xue-Lian Li

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Huang Lian" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Huang Lian" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Huang Lian" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2018 in the journal Evidence-Based Complementary and Alternative Medicine found that Berberine's potential similarity to metformin in addressing glycolipid metabolism and insulin sensitivity, and exploring promising combinations involving berberine, metformin, and cyproterone acetate for treating polycystic ovary syndrome with insulin resistance. The passage outlines the outcomes of a comprehensive study conducted in the context of treating polycystic ovary syndrome with insulin resistance (PCOS-IR). The study involved screening 225 potential studies, ultimately selecting 9 trials from 10 studies for meta-analysis. The quality assessment of included trials is summarized in Table 2. Notably, the comparisons between berberine (BBR) and metformin (MET), as well as between MET+BBR and MET alone, demonstrated intriguing results. The former comparison showed no significant differences in various parameters, while the latter revealed a combined treatment effect involving reductions in luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH) ratio, and testosterone. Another significant focus was the comparison between combining cyproterone acetate (CPA) with BBR versus CPA alone, showing a more favorable impact on parameters like waist-hip ratio, insulin resistance, and lipid profiles in the CPA+BBR group. The discussion delved into BBR's effects on glycolipid metabolism, insulin resistance, and reproductive endocrine conditions. It also explored the potential benefits of combining BBR with Chinese herbs and highlighted BBR's relatively positive safety profile. In conclusion, the study suggested BBR's promise in treating PCOS-IR, but underscored the necessity for further well-designed trials to substantiate its effects and mechanisms in various treatment contexts.

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