Rhizoma Coptidis: A Potential Cardiovascular Protective Agent
Tan HL, Chan KG, Pusparajah P, Duangjai A, Saokaew S, Mehmood Khan T, Lee LH, Goh BH · Frontiers in Pharmacology · 2016 October 07
DOI 10.3389/fphar.2016.00362
Objective
In China, RC is a common component in traditional medicines used to treat CVD associated problems including obesity, diabetes mellitus, hyperlipidemia, hyperglycemia and disorders of lipid metabolism. In recent years, numerous scientific studies have sought to investigate the biological properties of RC to provide scientific evidence for its traditional medical uses. The evidence available in the published literature indicates that RC is a herb with tremendous potential to reduce the risks of CVDs, and this review aims to summarize the cardioprotective properties of RC with reference to the published literature which overall indicates that RC is a herb with remarkable potential to reduce the risks and damage caused by CVDs.
Conclusions
In conclusion, results of recent studies appear to support for the usage of RC for treatment of CVDs and related conditions. RC appears to have tremendous potential as a cardioprotective agent given its ability to improve a large number of parameters associated with increased risk of CVDs including anti-atherosclerotic effect, lipid-lowering effect, anti-obesity effect and anti-hepatic steatosis effect. Aside from reducing incidence, it also reduces the damage caused by CVDs as it confers protection from myocardial I/R injury. However, knowledge regarding the underlying mechanisms of action of these compounds is still limited. More research investigating the exact mechanisms of RC's cardioprotective activities is needed.
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