Insights & Discussion
Tremella fuciformis polysaccharide alleviated hydrogen peroxide‑induced oxidative stress and apoptosis in skin fibroblasts via upregulation of SIRT1 expression, indicating that TFPS may act as a potential therapeutic agent for oxidative‑stress‑associated skin diseases and aging.
We demonstrated that pretreatment with TFPS suppressed H2O2-induced oxidative stress and apoptosis in skin fibroblasts in a concentration-dependent manner and possessed excellent antioxidative properties. Therefore, our present findings may provide a theoretical basis for TFPS as an alternative herbal food supplement and potential pharmacotherapy for skin injury and aging.
However, given that TFPS contains several polysaccharides and has a variety of pharmacological effects, our study, which focused on oxidative stress inhibition and anti-apoptotic effects, has limitations. Further studies are required to define the potential protective mechanisms of TFPS in H2O2-induced skin injury.
In summary, we revealed that TFPS exhibits protective properties against hydrogen peroxide-induced oxidative stress and apoptosis mainly by upregulating SIRT1 and promoting downstream signaling, suggesting that TFPS is a potential therapeutic agent for oxidative stress-related skin diseases and skin aging.
Discover Related Insights
Oral administration of Tremella fuciformis polysaccharides may constitute a new, effective therapy for Atopic dermatitis, improving both immune response and intestinal microbiota.
2022 Frontiers in Pharmacology Tremella fuciformis polysaccharides alleviate induced atopic dermatitis in mice by regulating immune response and gut microbiota Xie L, Yang K, Liang Y, Zhu Z, Yuan Z, Du Z
Experimental Study Eczema Gut Microbiota Polysaccharides
In the methodology of this study, the therapeutic effects of Tremella fuciformis polysaccharides (these have multiple biological activities), on Atopic dermatitis, were examined through both topical application and oral administration on mice induced with Atopic dermatitis-like disorder. The changes across transdermal water loss, epidermal thickening, and ear edema in the affected mice were observed. Notably, the study also considered the polysaccharides' impacts on the proportion of specific regulatory T cells in the mesenteric lymph nodes of the mice.
The results showed that both therapeutic methods positively impacted the conditions of the affected mice, with oral administration offering superior efficacy over topical application. The oral administration of the polysaccharides led to an increase of specific regulatory T cells, evidence of immune regulation. Further, non-targeted metabolomics and sequencing of certain DNA amplicons pointed towards observable modulation in fecal metabolites and a changed composition of gut microbiota in the mice following the oral treatment.
Tremella polysaccharide is a safe natural active ingredient, which can be used in the prevention, treatment and rehabilitation of diseases.
2021 International Journal of Immunopathology and Pharmacology A review on the production, structure, bioactivities and applications of Tremella polysaccharides Ma, X., Yang, M., He, Y., et al.
Systematic Review Polysaccharides
Tremella polysaccharide is a full-functioning active substance, and any of its activities are not independent, but complementary to other activities. For example, Tremella polysaccharides can participate in various physiological activities such as type II diabetes, cardiovascular disease, metabolic syndrome, inflammation and aging by regulating the expression of SIRT1 protein, which is in line with the guidelines of eastern medicine to maintain the dynamic balance of the human body through conditioning. Tremella polysaccharides are non-toxic and harmless natural ingredients that can be used for long-term contact with the human body by smearing or oral administration. It means that Tremella polysaccharides are suitable for the daily health needs of sub-healthy people and can be widely used in food, medicine and daily chemical products.
These results indicate that a certain concentration of snow fungus polysaccharides can effectively alleviate skin damage caused by UVA, and they may be used as an effective component of cosmetics.
2021 Journal of Cosmetic Dermatology Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways Fu H, You S, Zhao D, An Q, Zhang J, Wang C, et al.
Systematic Review Polysaccharides
Tremella fuciformis polysaccharides (TFPS) pretreatment can reduce the oxidative stress of UVA-treated human dermal fibroblasts cells. After TFPS pretreatment, the content of ROS and MDA in the cell decreased significantly and the total antioxidant activity was increased. Among them, the active of CAT, SOD, and GSH-Px in the cells increased significantly. TFPS can also protect fibroblasts by up-regulating Nrf2 and down-regulating Keap1 expression. Finally, it was also found that TFPS pretreatment increased the content of collagen I, elastin, and hyaluronic acid (HA) in skin fibroblasts treated with UVA.
Tremella fuciformis polysaccharides effectively reduce inflammation in ulcerative colitis, promoting healing by restoring intestinal and mucus barrier functions.
2021 International Journal of Biological Macromolecules Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function Xu Y, Xie L, Zhang Z, et al
Systematic Review Polysaccharides Ulcerative Colitis
In this study, two models were utilized to investigate the impacts of Tremella fuciformis polysaccharides on ulcerative colitis: a dextran sodium sulfate-induced mice model and a lipopolysaccharide-stimulated model using Caco-2 cells. First, the dextran sodium sulfate-induced mice ulcerative colitis model was administered with the Tremella fuciformis polysaccharides. Effects were observed across several indicators such as body weight, colon length, and thickness, as well as intestinal permeability.
Following that, histopathological analysis and electron microscope examinations helped delve deeper into the relationship, uncovering a reduction in inflammatory cell infiltration and a restoration of the intestinal epithelial barrier integrity. The lipopolysaccharide-stimulated Caco-2 cells model was used to further understand the role of these polysaccharides in reducing expressions of pro-inflammatory cytokines and increasing expressions related to intestinal barrier and mucus barrier.
The most important tremella mushroom benefits are anti-aging, anti-inflammatory, lower cholesterol, combat obesity, protect nerves and may fight cancer.
2020 Amazonian Journal of Plant Research Chemical compounds and health benefits of Tremella, a valued mushroom as both cuisine and medicine in ancient China and modern era Mohamad Hesam Shahrajabian, Wenli Sun, Hong Shen and Qi Cheng
Systematic Review Anti-Ageing Anti-Inflammatory
The most powerful nutritional constituents of Tremella are amino acids, vitamins, minerals, polysaccharides, Glucurmomannan 1,3-alpha-glucan, Epitope 9beta-D- glucuronosyl), Glucuronic acid, Glucurmic acid, Glucuronoxylomannan, N-acetylglucosamine, Flavonoids, Polyphenols, Alkaloids and Organic acids. Functional foods are making inroads into Chinese diets with their promises to improve health and nutrition. Chinese consumers should choose nutritional and healthy food to maintain general health and reduce the risk of health problems. Nutrition therapy on the basis of traditional Chinese medicine such tremella is quite effective at treating common diseases.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.