Tremella fuciformis, as a nutritional supplement, safely improved subjective memory complaints and cognitive functions in individuals suffering from subjective cognitive impairment.
Randomised Controlled Trial Cognitive Function Memory
Seventy-five individuals with subjective cognitive impairment were included in an 8-week, double-blind, randomized, placebo-controlled trial. Participants received either Tremella fuciformis (300mg/day or 600mg/day) or a placebo. The key point of assessment was fluctuations in questionnaire scores evaluating subjective memory complaints. Secondary measures involved changes in short-term memory and executive function performances, assessed using standardized cognitive tests. Effects on grey matter volume were examined using voxel-based morphometry.
The Tremella fuciformis group showed significant improvements in total questionnaire scores related to subjective memory complaints compared to the placebo group. Alongside this, substantial improvements were recorded in short-term memory and executive functions within the same group. Factors such as left precuneus, right supramarginal gyrus, right middle frontal gyrus, and right postcentral gyrus revealed significant group-to-visit interactions with no notable increase in adverse events among both high dose and low dose Tremella fuciformis groups, and the placebo group. These findings emphasize the potential of Tremella fuciformis as a safe nutritional supplement to alleviate subjective memory complaints and boost cognitive functions in individuals with subjective cognitive impairment.
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