This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
Insights & Discussion
Oral administration of Tremella fuciformis polysaccharides may constitute a new, effective therapy for Atopic dermatitis, improving both immune response and intestinal microbiota.
In the methodology of this study, the therapeutic effects of Tremella fuciformis polysaccharides (these have multiple biological activities), on Atopic dermatitis, were examined through both topical application and oral administration on mice induced with Atopic dermatitis-like disorder. The changes across transdermal water loss, epidermal thickening, and ear edema in the affected mice were observed. Notably, the study also considered the polysaccharides' impacts on the proportion of specific regulatory T cells in the mesenteric lymph nodes of the mice.
The results showed that both therapeutic methods positively impacted the conditions of the affected mice, with oral administration offering superior efficacy over topical application. The oral administration of the polysaccharides led to an increase of specific regulatory T cells, evidence of immune regulation. Further, non-targeted metabolomics and sequencing of certain DNA amplicons pointed towards observable modulation in fecal metabolites and a changed composition of gut microbiota in the mice following the oral treatment.
Discover Related Insights
Tremella polysaccharide is a safe natural active ingredient, which can be used in the prevention, treatment and rehabilitation of diseases.
2021 International Journal of Immunopathology and Pharmacology A review on the production, structure, bioactivities and applications of Tremella polysaccharides Ma, X., Yang, M., He, Y., et al.
Systematic Review Polysaccharides
Tremella polysaccharide is a full-functioning active substance, and any of its activities are not independent, but complementary to other activities. For example, Tremella polysaccharides can participate in various physiological activities such as type II diabetes, cardiovascular disease, metabolic syndrome, inflammation and aging by regulating the expression of SIRT1 protein, which is in line with the guidelines of eastern medicine to maintain the dynamic balance of the human body through conditioning. Tremella polysaccharides are non-toxic and harmless natural ingredients that can be used for long-term contact with the human body by smearing or oral administration. It means that Tremella polysaccharides are suitable for the daily health needs of sub-healthy people and can be widely used in food, medicine and daily chemical products.
These results indicate that a certain concentration of snow fungus polysaccharides can effectively alleviate skin damage caused by UVA, and they may be used as an effective component of cosmetics.
2021 Journal of Cosmetic Dermatology Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways Fu H, You S, Zhao D, An Q, Zhang J, Wang C, et al.
Systematic Review Polysaccharides
Tremella fuciformis polysaccharides (TFPS) pretreatment can reduce the oxidative stress of UVA-treated human dermal fibroblasts cells. After TFPS pretreatment, the content of ROS and MDA in the cell decreased significantly and the total antioxidant activity was increased. Among them, the active of CAT, SOD, and GSH-Px in the cells increased significantly. TFPS can also protect fibroblasts by up-regulating Nrf2 and down-regulating Keap1 expression. Finally, it was also found that TFPS pretreatment increased the content of collagen I, elastin, and hyaluronic acid (HA) in skin fibroblasts treated with UVA.
Tremella fuciformis polysaccharides effectively reduce inflammation in ulcerative colitis, promoting healing by restoring intestinal and mucus barrier functions.
2021 International Journal of Biological Macromolecules Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function Xu Y, Xie L, Zhang Z, et al
Systematic Review Polysaccharides Ulcerative Colitis
In this study, two models were utilized to investigate the impacts of Tremella fuciformis polysaccharides on ulcerative colitis: a dextran sodium sulfate-induced mice model and a lipopolysaccharide-stimulated model using Caco-2 cells. First, the dextran sodium sulfate-induced mice ulcerative colitis model was administered with the Tremella fuciformis polysaccharides. Effects were observed across several indicators such as body weight, colon length, and thickness, as well as intestinal permeability.
Following that, histopathological analysis and electron microscope examinations helped delve deeper into the relationship, uncovering a reduction in inflammatory cell infiltration and a restoration of the intestinal epithelial barrier integrity. The lipopolysaccharide-stimulated Caco-2 cells model was used to further understand the role of these polysaccharides in reducing expressions of pro-inflammatory cytokines and increasing expressions related to intestinal barrier and mucus barrier.