Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration—Neurodegenerative Disease
Mrowicka M, Mrowicki J, Kucharska E, Majsterek I · Nutrients · 2022 February 16
DOI 10.3390/nu14040827
Objective
To explore the role of lutein and zeaxanthin, xanthophyll carotenoids, in human health, focusing on their structural similarity, dietary sources, recommended daily intake, and importance for the proper functioning of organs such as the eyes, skin, heart, and intestines.
Conclusions
Lutein and zeaxanthin, obtained from sources like dark leafy vegetables and fruits, play a crucial role in defending against oxidative stress and scavenging free radicals. These carotenoids, concentrated in the macula of the retina, are essential for eye health. Specific binding proteins, StARD3 for lutein and GSTP1 for zeaxanthin, facilitate their accumulation in the retina. Supportive therapy with lutein and zeaxanthin has been shown to delay the progression of eye diseases, such as age-related macular degeneration (AMD) and cataracts. The article provides insights into the metabolism and bioavailability of these carotenoids, emphasizing the importance of consuming xanthophyll-rich foods.
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