Conclusions
Chrysanthemum flavonoids (CF) exhibited 41 differential genes, including Sqle, Gck, and Idi1, associated with cholesterol and fatty acid metabolism, and glycolysis; luteolin intervention primarily influenced the synthesis and transport of cholesterol with 68 differential genes, including Acsl3, Cyp7a1, and Lpin1; while luteoloside intervention showed 51 differential genes, including Acaca, Cyp7a1, and Lpin1, mainly associated with fatty acid metabolism. The study highlights the complexity of CF's mechanism in improving hyperlipidemia, suggesting distinct pathways compared to luteolin and luteoloside, necessitating further investigation into the roles of other components.
