The Gut Microbiome as a Major Regulator of the Gut-Skin Axis
Salem Iman, Ramser Amy, Isham Nancy, Ghannoum Mahmoud A. · Frontiers in Microbiology · 2018 July 10
DOI 10.3389/fmicb.2018.01459
Objective
In the current review, we describe the neoteric advancement in our comprehension of how the gut microbiota communicates with the skin as one of the main regulators in the gut-skin axis. We attempted to explore how this potential link affects skin differentiation and keratinization, its influence on modulating the cutaneous immune response in various diseases, and finally how to take advantage of this communication in the control of different skin conditions.
Conclusions
Basic science research and clinical studies have demonstrated the gut microbiome’s contribution to host homeostasis, allostasis, and the pathogenesis of disease. Through complex immune mechanisms, the influence of the gut microbiome extends to involve distant organ systems including the skin. With intentional modulation of the microbiome, probiotics, prebiotics, and synbiotics have proven beneficial in the prevention and/or treatment of inflammatory skin diseases including acne vulgaris, AD, and psoriasis.
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