Consumption of Cashew (Anacardium occidentale L.) Nuts Counteracts Oxidative Stress and Tissue Inflammation in Mild Hyperhomocysteinemia in Rats
D’Amico R, Cordaro M, Fusco R, Peritore A, Genovese T, Gugliandolo E, Crupi R, Mandalari G, Caccamo D, Cuzzocrea S, Di Paola R, Siracusa R, Impellizzeri D · Nutrients · 2022 April 01
DOI 10.3390/nu14071474
Objective
To evaluate the anti-inflammatory and antioxidant effects of cashew nuts in hyperhomocysteinemia (HHcy) induced by oral methionine administration for 30 days.
Conclusions
Cashew nuts (100 mg/kg orally, daily) demonstrated the ability to counteract clinical biochemical changes, oxidative and nitrosative stress, reduced antioxidant enzyme levels, lipid peroxidation, proinflammatory cytokine release, histological tissue injuries, and apoptosis in the kidney, colon, and liver of HHcy rats. The potential mechanisms involve the modulation of the antioxidant nuclear factor erythroid 2–related factor 2 (NRF-2) and inflammatory nuclear factor NF-kB pathways.
Critical Appraisal
Published research can offer valuable insights, but a paper’s conclusions may go beyond what its results support. Critical appraisal examines the methods, findings and limitations to clarify what can reasonably be concluded—and what remains uncertain.
This article has not yet been critically appraised by the Research Hub.
Learn more about Critical Appraisal
