Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps sinensis in the Treatment of Oral Lichen Planus
Ma H, Wang G, Guo X, Yao Y, Li C, Li X, Xin M, Xu X, Zhang S, Sun Z, Zhao H · Journal of Oncology · 2022 August 29
DOI 10.1155/2022/3156785
Objective
To investigate the mechanism of action of Cordyceps sinensis in treating oral lichen planus (OLP) and provide theoretical support for improving current treatment regimens for OLP.
Conclusions
Cordyceps sinensis contains multiple active compounds targeting key proteins such as TNF, IL-6, CD4, EGFR, and IL1B, regulating the PI3K-Akt and MAPK signaling pathways, and participating in biological processes like apoptosis, T cell activation, and oxidative stress, suggesting its potential as a crucial therapy for OLP.
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