Research Progress on the Pharmacological Action of Schisantherin A

Xiao Z, Xiao W, Li G · Evidence-Based Complementary and Alternative Medicine · 2022 February 12

DOI 10.1155/2022/6420865

Objective

To review the pharmacological effects and mechanisms of Schisantherin A (Sch A) isolated from Schisandra chinensis fruits.

Conclusions

Schisantherin A (Sch A) exhibits diverse pharmacological effects, including anti-Parkinson, anti-inflammatory, hepatoprotective, anti-ischemia-reperfusion injury, anti-osteoclast formation, and cognitive enhancement properties. Its mechanism of action involves antioxidant, anti-inflammatory, and antiapoptotic pathways mediated by MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways.

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