The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder
Zhou CH, Xue F, Shi QQ, Xue SS, Zhang T, Ma XX, Yu LS, Liu C, Wang HN, Peng ZW · Frontiers in Molecular Neuroscience · 2022 February 10
DOI 10.3389/fnmol.2022.812479
Objective
To investigate the influence of early electroacupuncture (EA) intervention on brain lipid composition in the hippocampus and prefrontal cortex (PFC) of mice subjected to a modified single prolonged stress (mSPS) model of PTSD.
Conclusions
Early intervention with EA alleviated PTSD-like behaviors induced by mSPS in mice, potentially mediated by region-specific normalization of lipid composition in the hippocampus. This suggests that EA may exert therapeutic effects in PTSD through modulation of the brain lipidome.
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