Jian‐Pi‐Yi‐Shen Formula Regulates Inflammatory Cytokines Production in 5/6 Nephrectomized Rats via Suppression of NF‐κB Activation

Lu J, Liu X, Liao Y, Wang D, Chen J, Li S · Evidence-Based Complementary and Alternative Medicine · 2018 January

DOI 10.1155/2018/7203547

Objective

To investigate whether the Jian-Pi-Yi-Shen formula (JPYSF) can retard chronic kidney disease (CKD) progression through inhibition of inflammation in a 5/6 nephrectomy rat model.

Conclusions

The study demonstrated that JPYSF significantly retarded CKD progression in the 5/6 nephrectomy rat model, likely through the inhibition of inflammation via the NF-κB signaling pathway.

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Insights

The Jian-Pi-Yi-Shen formula appears to slow down chronic kidney disease progression by inhibiting inflammation via the nuclear factor-kappa B signaling pathway.

In the method used for this study, a rat model was established using a 5/6 nephrectomy process. The rats were then segregated into two groups: one group given the Jian-Pi-Yi-Shen formula treatment, and another group that served as a control. The formula, measured at a dosage of 2.06g/kg per day, was administered to the rats via gavage over a six-week period. The results from this study revealed that the Jian-Pi-Yi-Shen formula treatment led to a substantial improvement in kidney function and a reduction in pathological injury in the rat model. A Multiplex analysis of various cytokines indicated that the formula triggered a reduction in proinflammatory cytokines and an increase in anti-inflammatory cytokine production. Additionally, the formula was found to inhibit the activation of the nuclear factor-kappa B signaling pathway that is typically associated with inflammation.