Jiawei Suanzaoren Decoction combined with lorazepam significantly improves sleep quality for chronic insomnia patients, offering a superior solution than using lorazepam alone.
Over the course of this study, 207 participants were split into two groups, namely, the treatment group and control group. The treatment group received a combination of Jiawei Suanzaoren Decoction and lorazepam orally, while the control group only received lorazepam. Several factors were evaluated at multiple stages including the Insomnia Severity Index, Self-Rating Depression Scale, Self-Rating Anxiety Scale, Somatic Self-rating Scale, and the MOS 36-item Short Form Health Survey. In addition, adverse effects were evaluated by the Treatment Emergent Symptom Scale.
Both the treatment and control groups showed significant improvements in their sleep onset latency and total sleep time. However, the Insomnia Severity Index reduction rate in the treatment group, which took both Jiawei Suanzaoren Decoction and lorazepam, was higher than that in the control group, who only took lorazepam. The study concluded that the combination of Jiawei Suanzaoren Decoction with lorazepam can significantly improve sleep quality with fewer adverse effects, demonstrating that it's an effective treatment that's superior to lorazepam alone for chronic insomnia.
