Salvia officinalis as a vaginal tablet, both alone and combined with Clotrimazole, can effectively treat Vulvovaginal Candidiasis.
In this randomized controlled trial, a total of 111 participants were divided up into three distinct treatment groups each consisting of 37 patients. The groups were: one that received a 100mg vaginal tablet of Clotrimazole with a placebo; another that received a 400mg vaginal tablet of S. officinalis and a placebo; and lastly, a group that received both a vaginal tablet of S. officinalis and Clotrimazole. These were administered once daily over the course of 7 days. Upon conclusion of the treatment, the presence of Vulvovaginal candidiasis was assessed through the presence of vaginal symptoms and wet tests, and confirmed if necessary, through cultures in the Chrome Agar Candida medium.
Discussions of the results indicate that, while there were no substantial differences between groups in terms of vaginal symptoms at the initial stages of the trial, differences emerged after the treatment was administered. Particularly, there was a marked decrease in positive Vulvovaginal candidiasis tests in the group that received both S. officinalis and Clotrimazole. Meanwhile, the S. officinalis and placebo group did not show a significant difference from the group that received Clotrimazole and the placebo. This suggests that the combination of S. officinalis and Clotrimazole can significantly improve the recovery from Vulvovaginal candidiasis.
