The Korean herbal formula showed no evidence of organ toxicity in rats after single or repeated high-dose oral exposure.
Male and female laboratory rats received the herbal formula by mouth in an initial single-dose toxicity study, followed by a four-week dose-ranging study and a thirteen-week repeated-dose study. Researchers compared treated groups with animals given distilled water and monitored clinical signs, survival, body weight, food intake, eye health, urine, blood measures, organ appearance and weight, and tissue structure under microscopic examination.
No deaths, major clinical abnormalities, or treatment-related changes were found across the assessed physiological, blood, urinary, organ, and tissue measures. Temporary increased salivation and a tendency toward greater body weight occurred at the highest dose, but these findings were not accompanied by organ damage or other adverse effects, indicating no identifiable target organ toxicity.
