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2023 Heliyon
Experimental Study Ferroptosis Retinitis Pigmentosa
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Chinese Medicine Research Hub
Experimental Study
Qi Shen Tang, a traditional Chinese medicine, was found to suppress retinal cell death in retinitis pigmentosa by inhibiting a process called ferroptosis.
2023 Heliyon Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway
Xiong M, Ou C, Yu C, Qiu J, Lu J, Fu C, Peng Q, Zeng M, Song H
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Qi Shen Tang" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Qi Shen Tang" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Qi Shen Tang" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Experimental Study published in 2023 in the journal Heliyon found that Qi Shen Tang, a traditional Chinese medicine, was found to suppress retinal cell death in retinitis pigmentosa by inhibiting a process called ferroptosis. The researchers investigated the potential mechanism of Qi-Shen-Tang (QST), a combination of two traditional Chinese medicines, on retinitis pigmentosa, an eye disease. They induced a retinitis pigmentosa model in mice while subsequently treating them with QST. They then examined the impact of the medicine on the tissue morphology and function of the retina in these model mice, in addition to monitoring factors such as retinal blood flow and fundus structure.
The study found that the treatment with QST led to notable improvements in the retinal tissue morphology and function. In addition, they observed an increase in retinal blood flow and normalization of the fundus structure. Following the treatment, the amounts of iron and malondialdehyde in the retinal tissue were significantly reduced, while the levels of superoxide dismutase, glutathione, and the protein expressions of various enzymes significantly increased. Molecular docking results also revealed potential interactions between the components of QST and key proteins of a particular signaling pathway, namely the Nuclear factor erythroid 2-related factor 2/ Glutathione peroxidase 4 pathway. The results suggest that QST may inhibit ferroptosis by suppressing this signaling pathway, thereby mitigating retinitis pigmentosa-induced damage to the retinal tissue.
