Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology
Liu C, Ma R, Wang L, Zhu R, Liu H, Guo Y, Zhao B, Zhao S, Tang J, Li Y, Niu J, Fu M, Zhang D, Gao S · Journal of Ethnopharmacology · 2017 February
DOI 10.1016/j.jep.2017.01.021
Objective
Emerging clinical usage and pharmacological effects have been achieved in using Rehmanniae Radix either singly or in combination with other herbs to treat skeletal diseases in traditional Chinese medicine (TCM) in the recent years. This study is aimed to provide a comprehensive review about the historical TCM interpretation of the action of Rehmanniae Radix in osteoporosis, its usage in clinical trials and osteoporotic models, its main phytochemical constituents, and its pharmacokinetics.
Conclusions
The successful inclusion of Rehmanniae Radix in clinical trials and preclinical studies for the management of osteoporosis has attracted rising attentions for identifying potential anti-osteoporotic candidates from this plant and clinical existing TCM formulas, which will further speed up anti-osteoporosis drug discovery processes. Properly designed and well controlled prospective studies are still needed to further demonstrate bone protective actions and safe use of this herb and its ingredients
Critical Appraisal
Published research can offer valuable insights, but a paper’s conclusions may go beyond what its results support. Critical appraisal examines the methods, findings and limitations to clarify what can reasonably be concluded—and what remains uncertain.
This article has not yet been critically appraised by the Research Hub.
Learn more about Critical Appraisal
Related insights
- Ba Ji Tian may prevent osteoporosis through the ovarian steroidogenesis signaling pathway. The anti-osteoporosis targets of Ba Ji Tian mainly play a role in the response to steroid hormones.
- Shu Di Huang, traditionally used in Chinese medicine, may effectively treat attention deficit hyperactivity disorder by rectifying neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failures.
- Acupuncture, in conjunction with Chinese herbs, enhances the treatment of uterine fibroids over the use of Chinese herbs alone.
- Fructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) shows potential as a clinical treatment for retinitis pigmentosa by inhibiting photoreceptor cell death following oxidative stress.
- The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
- Zhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties.
- Fermented Pueraria lobata root extract and Glycine max extract showed estrogen-like activities, reducing depressive symptoms in menopausal mice but not increasing female cancer risks.
- The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
