Traditional Chinese medicines as effective agents against influenza virus-induced pneumonia
Yang M, Wang Y, Yue Y, Liang L, Peng M, Zhao M, Chen Y, Cao X, Li W, Li C, Zhang H, Du J, Zhong R, Xia T, Shu Z · Biomedicine & Pharmacotherapy · 2022 September
DOI 10.1016/j.biopha.2022.113523
Objective
Influenza virus-induced pneumonia (IVP) is a high morbidity and contagiousness pulmonary infectious disease caused by invasion of the influenza virus into the lower respiratory tract. However, there are only few literature reviews on the prevention and treatment of IVP using TCMs. Therefore, we conducted a review of relevant literature from the past 10 years and a comprehensive analysis of various databases containing reports on TCMs used for IVP prevention and treatment to provide basic data for future research and development of drugs against IVP.
Conclusions
There has been some progress in the prevention and treatment of IVP by using TCMs. However, most research has focused on viral replication, the role of inflammatory cytokines, oxidative stress, and lung inflammatory cell infiltration in the pathogenesis of the disease, while there has been relatively little in-depth research on the lung lesions caused by influenza virus infection and on the role TCMs may have in preventing them. At present, analyses of the chemical components and mechanisms of action of TCMs useful in the treatment of IVP are insufficient, and this restricts their further use.
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