Neuroplasticity

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Chinese Medicine Research Hub

Experimental Study

A refined composition of Jiawei-Xiaoyao Pill, containing Gardeniae Fructus, Moutan Cortex, and Angelica Sinensis Radix, shows rapid antidepressant-like effects.

2024 Journal of Ethnopharmacology A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling
Wu Z, Yin Y, Liu R, Li X, Sun Y, Yau S, Wu L, Liu Y, Adzic M, Zhang H, Chen G

Chinese Medicine Research Hub

Review Article

Acupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment.

2022 Current Neuropharmacology Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression
Yang NN, Lin LL, Li YJ, Li HP, Cao Y, Tan CX, Hao XW, Ma SM, Wang L, Liu CZ

Chinese Medicine Research Hub

Review Article

Acupuncture effectively manages a range of post-spinal cord injury complications, including motor and sensory dysfunction, pain, neurogenic bowel and bladder, pressure ulcers, spasticity, and osteoporosis.

2018 Journal of Acupuncture and Meridian Studies Spinal Cord Injury: How Could Acupuncture Help?
Qianqian, F., Omer, C., Lize, X., & Yun, X.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Neuroplasticity" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Neuroplasticity" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Neuroplasticity" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Experimental Study published in 2024 in the journal Journal of Ethnopharmacology found that A refined composition of Jiawei-Xiaoyao Pill, containing Gardeniae Fructus, Moutan Cortex, and Angelica Sinensis Radix, shows rapid antidepressant-like effects. The methodology involved experimenting with individual herbs that are already known to exhibit antidepressant-like impacts. These herbs, including Moutan Cortex, Angelica Sinensis Radix, Bupleuri Radix, Paeonia Radix Alba, were combined with Gardeniae Fructus, each in proportions relative to their presence in Jiawei-Xiaoyao Pill, to find the desired formula. Rapid antidepressant effects were evaluated through the Novelty Suppressed Feeding Test and various other behavioral trials post a one-time administration. Once the formula was identified, it was then subjected to additional testing with a model that simulates depression using lipopolysaccharide. The results showed that a combination of Gardeniae Fructus, Moutan Cortex and Angelica Sinensis Radix, at their dosages proportional to Jiawei-Xiaoyao Pill, is capable of triggering rapid antidepressant-like reactions. Similar to the effects seen with Jiawei-Xiaoyao Pill and Scopolamine, this formula swiftly mitigated neuroinflammation signals and boosted neuroplasticity. It also offset the overexpression of certain NMDAR sub-units in the hippocampal region of mice under a depression model. It was observed that the formula rapidly revitalized the number of certain positive cells that had been diminished by depression simulation. The antidepressant effects of the formula and the upregulation of BDNF signaling were hindered by the use of rapamycin, an inhibitor of mTOR.

A Review Article published in 2022 in the journal Current Neuropharmacology found that Acupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment. The study under review examines the possible mechanisms and clinical effectiveness of acupuncture in the treatment of different forms of depression. To do this, the researchers examined existing studies and evidence involving both human patients and animal models. A significant aspect of the investigation involved assessing how acupuncture influences neuroplasticity within the hippocampus and neural networks, along with probing the role of this non-pharmaceutical therapy in modulating brain inflammation, which had potential implications for alleviating depressive disorders. The discussions of the results indicated that acupuncture showed considerable promise in the relief of primary depression, especially in milder cases. It was also found useful in the management of post-stroke depression, pain-related depression, and post-partum depression. The study noted positive outcomes both when acupuncture was offered as a stand-alone treatment, and when combined with conventional pharmacological treatments. It was observed that the combination of acupuncture and anti-depressant drugs not only improved primary and secondary depressive symptoms but also managed to reduce the side-effects often associated with medication regimens, which are frequent contributors to high dropout rates in pharmacological treatments.

A Review Article published in 2018 in the journal Journal of Acupuncture and Meridian Studies found that Acupuncture effectively manages a range of post-spinal cord injury complications, including motor and sensory dysfunction, pain, neurogenic bowel and bladder, pressure ulcers, spasticity, and osteoporosis. The effect of acupuncture on post-spinal cord injury orthostatic hypotension and sexual dysfunction remains unclear. Decreased oxidative stress, inhibition of inflammation and neuronal apoptosis, regulation of the expression and activity of endogenous biological mediators, and increased regenerative stem cell production are the possible mechanisms of acupuncture therapy for spinal cord injury. Although many limitations have been reported in previous studies, given the evidence for the efficacy of acupuncture, we recommend that physicians should support the use of acupuncture therapy for SCI complications.

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