Chai Hu Shu Gan San

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Chinese Medicine Research Hub

Chaihu Shugan powder, a traditional Chinese medicine, presents potential advantages in treating post-stroke depression, showing potential as an alternative to conventional antidepressants.

2022 Medicina A Chinese Classical Prescription Chaihu Shugan Powder in Treatment of Post-Stroke Depression: An Overview
Gao Z, Wang Y, Yu H

Chinese Medicine Research Hub

The Chaihu Shugan Formula, a traditional Chinese medicine, not only effectively modulates intestinal gut microbiota but also strengthens gut barrier integrity and contains powerful anti-inflammatory properties.

2022 Frontiers in Pharmacology The Modulation of Chaihu Shugan Formula on Microbiota Composition in the Simulator of the Human Intestinal Microbial Ecosystem Technology Platform and its Influence on Gut Barrier and Intestinal Immunity in Caco-2/THP1-Blue™ Cell Co-Culture Model
Liu L, Lu Y, Xu C, Chen H, Wang X, Wang Y, Cai B, Li B, Verstrepen L, Ghyselinck J, Marzorati M, Yao Q

Chinese Medicine Research Hub

Systematic Review

Chai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases.

2018 BMC Complementary Medicine and Therapies Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials
Sun Y, Xu X, Zhang J, Chen Y

Chinese Medicine Research Hub

Systematic Review

TCM pattern-based treatments for depression frequently use Xiao Yao and Chai Hu Shu Gan decoctions, with Bai Shao and Chai Hu herbs common across different TCM patterns.

2015 Evidence-Based Complementary and Alternative Medicine Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review
Yeung WF, Chung KF, Ng KY, Yu YM, Zhang SP, Ng BFL, Ziea ETC

Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Chai Hu Shu Gan San" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

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A published in 2022 in the journal Medicina found that Chaihu Shugan powder, a traditional Chinese medicine, presents potential advantages in treating post-stroke depression, showing potential as an alternative to conventional antidepressants. The research approach merges both clinical and experimental studies in exploring the effectiveness of Chaihu Shugan powder, a classic traditional Chinese medicine formula, in treating post-stroke depression. Starting from current clinical cases, the study thoroughly investigates the mechanisms of action and drug and chemical effects of this treatment. The attention is given to the performance of Chaihu Shuan powder in counteracting post-stroke depression, focusing on patients who have not shown an adequate response or experienced adverse reactions to commonly used antidepressants like selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. The results indicate outstanding benefits of the Chinese herbal treatment for post-stroke depression. It shows that Chaihu Shugan powder could potentially offer a significant contribution to incapacity and recovery of cognitive dysfunction and motor function after a stroke. It also helps to prominently lessen the probability of neurovascular events coming back. This highlights the values of Chaihu Shugan powder that serves as an effective and promising alternative to the standard drug treatments for post-stroke depression.

A published in 2022 in the journal Frontiers in Pharmacology found that The Chaihu Shugan Formula, a traditional Chinese medicine, not only effectively modulates intestinal gut microbiota but also strengthens gut barrier integrity and contains powerful anti-inflammatory properties. The study began by analysing the impact of the Chaihu Shugan Formula (CSF) on the simulated colonic microbiota of five healthy donors, while concurrently examining gut barrier integrity, and intestinal immunity. This was achieved by marrying the use of the simulator of the human intestinal microbial ecosystem technology platform with the co-culture of intestinal and immune cells. The examination revealed an increase in the production of certain healthy short-chain fatty acids, a boost in health-promoting Bifidobacterium species, and a decrease in certain pathogenic branching short-chain fatty acids. The proceeding phase of the study investigated the influence of colonic fermentation of CSF on gut barrier and intestinal immunity utilizing the Caco-2/THP1-blue™ cell co-culture model. The research demonstrated that CSF induces protective effects on inflammation-induced intestinal epithelial barrier disruption. Concurrently, the study benignly revealed the treatment of CSF unfailingly unveiling pronounced anti-inflammatory properties induced by the stimulation of anti-inflammatory cytokines IL-6 and IL-10 and the reduction of the pro-inflammatory cytokine TNF-α.

A Systematic Review published in 2018 in the journal BMC Complementary Medicine and Therapies found that Chai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases. The review assessed the efficacy of Chai Hu Shu Gan San, a traditional Chinese medicine, in treating depression. Out of 560 initial studies, 42 trials met inclusion criteria. These studies were conducted in China from 2006 to 2016, involving 3234 patients with depression. Chai Hu Shu Gan San demonstrated better efficacy compared to controls, especially in post-stroke and postpartum depression. However, the methodological quality of the included studies was assessed as low, with high risks of bias. While Chai Hu Shu Gan San showed promise, further rigorously designed randomized controlled trials are needed for a conclusive evaluation of its safety and efficacy in treating depression.

A Systematic Review published in 2015 in the journal Evidence-Based Complementary and Alternative Medicine found that TCM pattern-based treatments for depression frequently use Xiao Yao and Chai Hu Shu Gan decoctions, with Bai Shao and Chai Hu herbs common across different TCM patterns. The methodology incorporated a systematic review of randomized controlled trials from both Chinese and English literatures regarding traditional Chinese medicine (TCM) pattern-based treatments for depression. This encompassed a total of 61 studies and 2504 subjects across 27 TCM patterns. Due to varied TCM patterns among participants, the analysis focused on the four most prevalent ones: liver qi depression, liver depression and spleen deficiency, dual deficiency of the heart and spleen as well as liver depression and qi stagnation. In the discussion of results, it was found that Xiaoyao decoction was most frequently used for the treatment of liver qi depression and liver depression with spleen deficiency, whereas Chaihu Shugan decoction was typically used for liver depression and qi stagnation. Commonly used herbs regardless of the prescribed Chinese herbal formulas included Bai Shao and Chai Hu. Typically, the individual studies did not provide an underlying rationale for herb selection, limiting the conclusions one could draw regarding the efficacy of certain herbal formulas and the response of specific TCM patterns to these treatments.

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