The herbal formula B210 can alleviate snoring in aged rats by modifying the activities and breathing time of relevant nerves.
In this study, aged rats were treated intraperitoneally with the herbal formula B210, a compound of specific herbal components, or a placebo (sham treatment). The effects of the treatment on snoring quality were analysed by comparing pressure and frequency of snoring, activities of the phrenic nerve, the recurrent laryngeal nerve, and the hypoglossal nerve, as well as inspiratory time and expiratory time of the phrenic nerve, and pre-inspiratory time of the hypoglossal nerve.
The results of the study showed that the rats that received the B210 treatment exhibited a marked decrease in snoring pressure and frequency, compared to those that received the sham treatment. Furthermore, there was a notable increase in the activities of the upper airway related nerves - the phrenic nerve, the recurrent laryngeal nerve, and the hypoglossal nerve - observable in the aged rats that received the B210 treatment, demonstrating an extension in the inspiratory and expiratory times of the phrenic nerve, and a prolongation of the pre-inspiratory time of the hypoglossal nerve. These findings point to the possibility of B210's role in alleviating snoring through modulating the activities and breathing times of the nerves related to the upper airway in aged rats.
