Chinese Cinnamon

Presentation Slides

Chinese Medicine Research Hub

Review Article

Cinnamomum cassia, or cinnamon, exhibits promising therapeutic benefits in combating gastritis by targeting inflammation pathways, according to preclinical studies.

2021 Applied Biological Chemistry Potential and beneficial effects of Cinnamomum cassia on gastritis and safety: Literature review and analysis of standard extract
Lee JH, Park DH, Lee S, Seo HJ, Park SJ, Jung K, Kim SY, Kang KS

Chinese Medicine Research Hub

Randomised Controlled Trial

DKB114, a mixture of Linn flower extract, effectively reduces serum uric acid level, suggesting its potential as a dietary supplement for hyperuricemia treatment.

2020 Nutrients A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial for Evaluation of the Efficacy and Safety of DKB114 on Reduction of Uric Acid in Serum
Park YH, Kim DH, Lee JS, Jeong HI, Lee KW, Kang TH

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation significantly decreases inflammation and oxidative stress levels, serving as a potential additive for cardiometabolic health improvement.

2020 Complementary Therapies in Medicine Impact of Cinnamon Supplementation on cardiometabolic Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Zhu, Changyou; Yan, Hongmei; Yin, Zheng; Santos, Heitor O; Melahat Sedanur Macit; et al

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation may help manage metabolic parameters in polycystic ovary syndrome patients by reducing fasting blood sugar, insulin, LDL-C, total cholesterol, and triacylglycerol levels.

2020 Journal of Ethnopharmacology Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis
Heydarpour F, Hemati N, Hadi A, Moradi S, Mohammadi E, Farzaei MH

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation can improve blood pressure by a modest degree.

2020 Clinical Nutrition ESPEN The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials
Hadi A, Campbell MS, Hassani B, Pourmasoumi M, Salehi-sahlabadi A, Hosseini SA

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation in type 2 diabetes patients significantly reduces systolic and diastolic blood pressure, but doesn't significantly affect body weight and waist circumference.

2020 Diabetes & Metabolic Syndrome: Clinical Research & Reviews Effect of cinnamon supplementation on blood pressure and anthropometric parameters in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials
Jamali N, Jalali M, Saffari-Chaleshtori J, Samare-Najaf M, Samareh A

Chinese Medicine Research Hub

Systematic Review

Cinnamon intake significantly reduces body weight, body mass index, waist circumference, and fat mass in adults, and can be recommended as a supplement for obesity management.

2020 Clinical Nutrition Cinnamon supplementation positively affects obesity: A systematic review and dose-response meta-analysis of randomized controlled trials
Mousavi SM, Rahmani J, Kord-Varkaneh H, Sheikhi A, Larijani B, Esmaillzadeh A

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation can significantly reduce body weight, body mass index, and waist-hip ratio.

2019 Phytotherapy Research Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta-analysis of controlled clinical trials
Zeinab Yazdanpanah,Maryam Azadi-Yazdi,Hadis Hooshmandi,Nahid Ramezani-Jolfaie,Amin Salehi-Abargouei,

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation leads to a significant reduction in both systolic and diastolic blood pressure in adults.

2019 Critical Reviews in Food Science and Nutrition Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials
Seyed Mohammad Mousavi, Ahmad Jayedi, Yahya Jalilpiran, Maryam Hajishafiee, Azadeh Aminianfar, Ahmad Esmaillzadeh.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Chinese Cinnamon" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Chinese Cinnamon" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Chinese Cinnamon" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2021 in the journal Applied Biological Chemistry found that Cinnamomum cassia, or cinnamon, exhibits promising therapeutic benefits in combating gastritis by targeting inflammation pathways, according to preclinical studies. This study is a systematic review of 20 studies evaluating the pharmacological effects and mechanisms of C. cassia in treating gastritis. Focusing on the main active compound of C. cassia, cinnamaldehyde, the research was centered around its influence on inflammation pathways. Furthermore, different methodologies were used to induce gastric ulcers, including stress, alcohol, excessive acidity, and the prolonged usage of non-steroidal anti-inflammatory drugs (NSAIDs). The result discussion highlights the success C. cassia extract demonstrated in protecting against gastritis. Key findings stemmed from preclinical tests, with predominantly animal models, including Beagle dogs and rats. The ingestion of standardized C. cassia extracts showed positive effects with no toxicity, asserting the effectiveness and safety of this natural remedy in managing gastritis.

A Randomised Controlled Trial published in 2020 in the journal Nutrients found that DKB114, a mixture of Linn flower extract, effectively reduces serum uric acid level, suggesting its potential as a dietary supplement for hyperuricemia treatment. The research employed a randomized, double-blind, placebo-controlled clinical trial conducted across a span of 12 weeks. A total of 80 asymptomatic hyperuricemic subjects (serum uric acid level between 7.0-9.0 mg/dL) were selected and equally split into two groups. One group was administered DKB114, the investigational mixture of extracts, while the other group received a placebo. After six weeks of administration, the levels of serum uric acid were evaluated, revealing no significant difference between the two groups. By the end of the 12th week, however, subjects in the DKB114 group exhibited a noticeably larger decrease in their serum uric acid levels when compared to the placebo group. Additionally, various other health indicators including C-reactive protein and apoprotein B levels showed significant trends favoring DKB114. Further evaluations during the trial included clinical pathological tests, weight measurements and vital signs, and electrocardiogram tests which confirmed the safety of DKB114. No significant harmful effects or differences were detected in comparison to the placebo group. This concludes the positive impact and safe use of DKB114 for patients with elevated serum uric acid levels.

A Systematic Review published in 2020 in the journal Complementary Therapies in Medicine found that Cinnamon supplementation significantly decreases inflammation and oxidative stress levels, serving as a potential additive for cardiometabolic health improvement. The systematic review and meta-analysis followed the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines. A comprehensive search for appropriate clinical trials was performed across multiple databases including PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, and Google Scholar until January 2020. After duplicates were removed, 1145 studies were found eligible and 12 studies were finally included in the meta-analysis, investigating the impact of cinnamon supplementation dosages ranging between 1.5 to 4 grams per day. The results of the meta-analysis revealed that cinnamon supplementation led to a significant reduction in inflammation markers, C-reactive protein and interleukin-6, alongside a decrease in malondialdehyde, an oxidative stress marker. Concurrently, an increase was observed in the total antioxidant capacity following the supplementation, implying an enhancement in the body's defensive ability against oxidative damage. Nevertheless, no significant change was identified in the levels of intercellular adhesion molecule-1 after the cinnamon supplementation.

A Systematic Review published in 2020 in the journal Journal of Ethnopharmacology found that Cinnamon supplementation may help manage metabolic parameters in polycystic ovary syndrome patients by reducing fasting blood sugar, insulin, LDL-C, total cholesterol, and triacylglycerol levels. In order to evaluate the effect of cinnamon supplementation on metabolic parameters of PCOS patients, relevant clinical trials were systematically reviewed and analysed. Data was collated from multiple credible databases including PubMed, Embase, the Cochrane library, Scopus and Web of Science, up until August 2019. Studies were selected that provided information specifically about the impact of cinnamon supplementation on metabolic parameters amongst PCOS patients. Standard methods were used to assess heterogeneity, publication bias and sensitivity analysis with five clinical trials pooled together using a weighted mean-difference calculation. The findings of the meta-analysis showed that cinnamon supplementation does not significantly affect body weight and body mass index in PCOS patients. However, it was found that cinnamon supplementation led to a significant decrease in fasting blood sugar, fasting insulin, and HOMA-IR, along with reducing the serum levels of LDL-C, total cholesterol, and triacylglycerol. Additionally, there was an observed improvement in serum concentration of HDL-C with cinnamon supplementation. Ultimately illustrating that cinnamon supplementation may play a significant role in managing metabolic parameters in polycystic ovary syndrome patients.

A Systematic Review published in 2020 in the journal Clinical Nutrition ESPEN found that Cinnamon supplementation can improve blood pressure by a modest degree. Meta-analysis of 9 RCTs with 641 participants showed significant reductions in both systolic (WMD: −5.17 mmHg, 95% CI: −9.35 to −0.99, P = 0.01) and diastolic blood pressure (WMD: −3.36 mmHg, 95% CI: −5.67 to −1.04, P ≤ 0.001) after cinnamon supplementation. Subgroup analyses indicated that these results were significant only when cinnamon was administered at the dosages of ≤2 g/day, for a period longer than 8 weeks, and in participants with a baseline BMI of ≥30 kg/m2.

A Systematic Review published in 2020 in the journal Diabetes & Metabolic Syndrome: Clinical Research & Reviews found that Cinnamon supplementation in type 2 diabetes patients significantly reduces systolic and diastolic blood pressure, but doesn't significantly affect body weight and waist circumference. This systematic review and meta-analysis diligently looked for related studies in databases like PubMed, Embase, Scopus, Web of Science and Cochrane Library. The search was conducted up to August 22, 2019, and aimed at finding the impact of cinnamon supplementation on blood pressure and certain anthropometric parameters among patients with type 2 diabetes. To gauge the effectivity, they used standard mean difference and confidence intervals. In cases of heterogeneity, fixed and random effect models were utilized. The collated data was analyzed using Stata 13. After refining the records, nine suitable articles were chosen for review. The meta-analysis results indicated a significant decrease in systolic and diastolic blood pressure in type 2 diabetic patients following the incorporation of cinnamon in their diet. However, the supplement did not result in a significant change in their body weight, body mass index, and waist circumference. These fluctuations in anthropometric factors were noted, but they did not reach a level of statistical significance.

A Systematic Review published in 2020 in the journal Clinical Nutrition found that Cinnamon intake significantly reduces body weight, body mass index, waist circumference, and fat mass in adults, and can be recommended as a supplement for obesity management. Various online search engines such as PubMed, SCOPUS, Google Scholar, and Cochrane Library were trawled to find relevant articles on the impact of cinnamon consumption on obesity measures. The data from these articles was then combined and expressed as weighted mean difference and 95% confidence intervals utilizing the random-effects method. The potential non-linear association was appraised via fractional polynomial modeling. The study incorporated 12 trials from an initial pool of 679 records, bringing together a total of 786 participants. The aggregated outcome demonstrates that cinnamon intake can significantly decrease body weight, body mass index, waist circumference, and fat mass in adults. The impact on body weight was particularly pronounced in subjects under 50 years old and those with a higher baseline body mass index (≥30 kg/m). Daily dosages of cinnamon at or above 2 grams, and administered for 12 weeks or more resulted in significant reductions in fat mass. There was a non-linear reduction in body weight and waist circumference with the administration of cinnamon over the study period.

A Systematic Review published in 2019 in the journal Phytotherapy Research found that Cinnamon supplementation can significantly reduce body weight, body mass index, and waist-hip ratio. In the meta-analysis, various databases (including Medline, ISI Web of Science, Scopus, Google Scholar, and Cochrane Library) were searched without limitations until August 2019 for relevant randomized controlled clinical trials. The risk of bias of the randomized controlled clinical trials was appraised with the Cochrane collaboration's tool. The random-effects model was employed for the meta-analysis. The conclusive results indicate that cinnamon supplementation has a notable effect in reducing body mass index, body weight, and waist-hip ratio. Meanwhile, cinnamon supplementation didn't yield significant effects on waist circumference and body fat mass. These results were deduced from twenty-one randomized controlled trials involving a total of 1,480 participants.

A Systematic Review published in 2019 in the journal Critical Reviews in Food Science and Nutrition found that Cinnamon supplementation leads to a significant reduction in both systolic and diastolic blood pressure in adults. This systematic review and meta-analysis included studies up to July 2019, sourced from databases like PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. The research focused on randomized clinical trials that primarily explored the effect of oral cinnamon supplementation on blood pressure parameters, including systolic or diastolic blood pressure. From the 469 citations, nine trials involving 641 subjects were included. The results inferred that cinnamon supplementation leads to a noticeable decrease in both systolic and diastolic blood pressure. A more remarkable effect on systolic blood pressure was observed in trials using less or equal to 2g cinnamon, lasting for 12 weeks or more, and included participants under the age of 50. Diastolic blood pressure was also reduced using lower doses of cinnamon. No significant non-linear associations were detected between cinnamon supplementation dosage, study duration, and both systolic and diastolic blood pressure.

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