Antiviral

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• Definition
• Introduction
• Signs & Symptoms
• Research Summary

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Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Antiviral" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Antiviral" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Antiviral" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2023 in the journal Molecules found that Bee pollen showcases a range of biological activities, such as anti-inflammatory, antimicrobial, and potential antiviral properties, which could contribute to the creation of innovative therapies. The methodology used in the study involved analysing a diverse array of pollen types, in combination with their various chemical compositions. The primary aim of this was to updatedly assess the bioactive constituents present in bee pollen and consider the therapeutic possibilities they present. A focus of the study was on beehive pollen since it is a rich natural source of proteins and nutrients and exhibits immense chemical and therapeutic potential. Discussion of results emphasized that the range of biological activities associated with bee pollen is truly remarkable. This activity ranges from anti-inflammatory and antimicrobial properties to potential antiviral and anticancer applications. Despite the challenge presented in fully understanding the vast array of biological properties across various pollen sources, this study has succeeded in emphasizing the potential extent of the therapeutic effectiveness of bee pollen. Its potential contribution on the path to discovering innovative therapies cannot be underestimated.

A Review Article published in 2023 in the journal Food Chemistry Advances found that Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties. In the methodological approach of the study, a comprehensive review was undertaken to collate information on the bioactive components found within pomegranates and their by-products (aril, seed, and peel). The study emphasized the pomegranate peel's properties owing to its high content of the bioactive compounds. The aim was to elucidate the nutritional and functional aspects of pomegranates, particularly as a functional food. The results outlined that pomegranates, especially their peel, contain bioactive compounds, including punicalagin, punicalin, ellagic acid, punicic acid, and anthocyanins. Therefore, they have potential functional properties such as antimicrobial, anticancer, and antiviral characteristics. These results suggest that pomegranates could be explored to develop nutraceutical or functional food products due to their profound properties. The peel of the pomegranate, specifically, showcases significant potential for development due to its higher bioactive compound content compared to other parts of the fruit.

A Experimental Study published in 2023 in the journal Foods found that Bee-collected pollen and bee bread, particularly when artificially fermented, demonstrate significant antiviral activity against the H1N1 strain of the influenza A virus. The research investigated the antiviral properties of bee-collected pollen (BCP) and bee bread (BB), including versions that had undergone artificial fermentation. The experiment also assessed separate proteins, water content, and -butanol portions of these substances. The analysis evaluated their effectiveness against the H1N1 strain of the influenza A virus (IAV). The antiviral behavior of these materials was taken in lab conditions via a comparative real-time PCR analysis working on their inhibitory concentration and selectivity index. The outcomes revealed artificial fermentation improved the antiviral effectiveness of BCP. The protein fractions within the BCP and BB presented the greatest antiviral activity. Observations also highlighted that the chemical composition, prominent in proteins, and potentially microbiome metabolism determined the antiviral properties of BCP and BB. The chemical profile analysis emphasized the existence of some specialized metabolites that might be contributing towards this antiviral action.

A Systematic Review published in 2022 in the journal Oxidative Medicine and Cellular Longevity found that Ginger, native to Southeast Asia, possesses antioxidant and antiviral properties, contributing to healthy ageing and potential prevention of age-related disorders. The study explored the natural benefits of ginger, a plant native to Southeast Asia renowned for its culinary and medicinal uses. The approach focused on examining the plant's antioxidant, anti-inflammatory, anticancer, antimicrobial, and particularly antiviral properties from its rich collection of antiviral compounds. The process involved digging into accumulated evidence that suggests ginger's role in promoting healthy ageing, reducing morbidity, and prolonging a healthy lifespan, thus providing a natural solution for an age-old problem. In terms of results, the examination of evidence proved affirming. Ginger displayed significant potential in boosting healthy ageing, reducing the risk of age-related disorders, and extending a wholesome life expectancy due to its inherent properties. The plant's antioxidant characteristics played a key role in these outcomes, along with its anti-inflammatory and antiviral attributes. In essence, the research unfolded a rather underexplored potential of a common natural product in tackling age-induced health conditions.

A Review Article published in 2022 in the journal Pharmacological Research - Modern Chinese Medicine found that The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms. The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19. Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.

A Review Article published in 2022 in the journal Brazilian Journal of Pharmaceutical Sciences found that High doses of vitamin C, vitamin D supplementation and natural honey can potentially decrease fatalities and support the management of COVID-19. The team undertook a systematic analysis of existing literature and pertinent clinical trials to evaluate the potential of vitamin C, vitamin D, and natural honey intervention during the progression of the COVID-19 pandemic. This assessment aimed to determine the impact of these substances upon the outcomes of COVID-19, particularly in reducing respiratory damage and potentially improving patient immunity. The research revealed that substantial doses of vitamin C illustrated to lower lung damage and reduce intensive care stay duration for COVID-19 patients. It was observed that vitamin D deficiency is common among individuals living in institutions, and having supplements could aid in defending against respiratory infections. Natural honey, due to its antiviral effects and immune-enhancement capacities, also displayed promising results in treating COVID-19. The acquired evidence drove the belief that administering vitamin C, vitamin D, and natural honey, along with the existing treatment protocols, could potentially be a compelling method to decrease fatalities associated with COVID-19.

A Review Article published in 2021 in the journal Frontiers in Pharmacology found that Yu Xing Cao, a traditional Asian medicine, demonstrates organ protection, immune regulation, and anti-tumour activity when analysed in modern research. The methodology used in this review began by harnessing key search terms such as 'H. cordata and lung', 'H. cordata and heart', 'H. cordata and liver', and 'H. cordata and inflammation' to query research databases including PubMed, Web of Science and ScienceDirect. The focus was on articles published within the past decade that aligned significantly with the chosen keywords. Contents, disease models and research methods from these articles were analysed to form a comprehensive understanding of H. cordata's therapeutic effects. Results from the review found that H. cordata contained a variety of chemical constituents common to medicinal plants, including flavonoids and volatile oils, identified as the main active components. The plant demonstrated a range of pharmacological activities including organ protection, where it reduced the release of inflammatory factors to alleviate lung injury. The immunity regulation aspect enhanced immune barriers in the vagina, oral cavity, and intestinal tract, reducing pathogen infection due to its combined antibacterial and antiviral activity. It was also observed to have anti-inflammatory and anti-tumour properties, with a noted effect on lung, liver, colon, and breast tumours.

A Review Article published in 2021 in the journal Journal of the Science of Food and Agriculture found that Curcumin, derived from turmeric, exhibits an extensive range of biological and medicinal properties, including anti-inflammatory, antioxidant, and antifungal qualities. The research examines turmeric extracts, specifically focusing on curcumin, a yellow biocomponent. An array of its medicinal and biological properties is explored, particularly anti-inflammatory, antioxidant, and antifungal attributes. Traditionally used in various cultures for a range of health issues like inflammation, cough, wounds, liver disorders, and cancers, curcumin's extensive application in treating a variety of diseases potentially positions it as a significant component in modern medicine. The study also notes the successful tolerance of curcumin at high doses with no adverse effects. The analysis extends to the preferred methods for the encapsulation of curcumin, detailing techniques such as nanocomplexing, gelation, complex coacervation, electrospraying, and solvent-free pH-driven encapsulation. These methods have demonstrated effectiveness in encapsulating curcuminoids. Moreover, the chemical traits of curcumin are also highlighted, providing a basis for further potential applications in the development of health-promoting functional products.

A Systematic Review published in 2021 in the journal Molecules found that Green tea consumption has been found to be effective in preventing the contraction of influenza infections. To identify the potential benefits of green tea in influenza prevention, a methodical review and combined analysis of eight distinct research studies involving 5,048 participants was completed. The effect of green tea catechin treatment was tested against control conditions and assessed based on infection rates. Five of these studies were randomized controlled trials involving 884 participants and three were cohort studies with 2,223 participants. Subgroups such as those who gargled or took orally ingested forms of green tea were also analyzed separately. Further to this, the possibility of publication biases was evaluated using Begg's and Egger's tests. The results showed both the randomized trials and the cohort studies displayed significant preventative effects on influenza infection for those treated with green tea catechins. Notably, there was no evidence of non-uniformity within the data, reinforcing these findings. The pooled results of different consumption methods further supported these findings, showing no disparities among the subgroups. These results suggest the consumption of green tea has tangible prophylactic effects against influenza infection.

A Review Article published in 2021 in the journal Molecules found that Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity. The study's methodology involved a comprehensive review of the literature on the potential anti-COVID-19 effects of bee honey and propolis, products known for their strong antimicrobial and antioxidant abilities. The researchers conducted molecular simulations to see how various flavonoids found in these products might inhibit essential viral processes. Additionally, they compared the effectiveness of propolis extracts delivered by nanocarriers to ethanolic extracts, and they examined the effects of a combination of honey and propolis on hospitalized COVID-19 patients. The findings from the review and simulations suggested that certain flavonoids in honey and propolis may inhibit the fusion of the virus spike with host cells, interactions that cause a cytokine storm, and viral replication. Propolis ethanolic extract, rutin, and propolis liposomes displayed inhibitory action against non-structural proteins of the virus in vitro while naringin inhibited viral infection in specific cells. When delivered via nanocarriers, propolis extracts showed enhanced antiviral effects against the virus compared to ethanolic extracts. Observations of hospitalized patients suggested that those treated with green Brazilian propolis or a honey-propolis combination experienced quicker viral clearance, symptom recovery, and hospital discharge, along with lower mortality rates.

A Review Article published in 2020 in the journal Molecules found that Honey's phytochemical components and bioactive compounds have potential antiviral effects, potentially making it an effective natural product against COVID-19. The methodology of this research utilizes a comprehensive review and analysis of existing literature regarding the antiviral effects and phytochemical components of honey. Previous studies have indicated that certain bioactive compounds present in honey, such as methylglyoxal, chrysin, caffeic acid, galangin, hesperidin, levan, and ascorbic acid, may exhibit antiviral effects or stimulate the body's antiviral immune responses. Through thorough examination of past works, the researchers isolated and focused on these compounds, exploring their potential utility in the context of COVID-19, a novel coronavirus that currently lacks established preventative or treatment measures. The results of the analysis pointed towards the efficacy of honey's bioactive compounds, which were found to potentially display both direct antiviral effects and the promotion of antiviral immune responses. However, the precise mechanisms by which these compounds exert their antiviral activity, particularly against SARS-CoV-2, remain largely unclear. Despite these ambiguities, the research established honey as a fruitful field of study for potential therapeutic material against the novel coronavirus disease.

A Review Article published in 2020 in the journal Frontiers in Pharmacology found that Traditional Chinese medicine has unique advantages in relieving symptoms, shortening treatment time and reducing the development of severe viral pneumonia. In the treatment of viral pneumonia through syndrome differentiation, traditional Chinese medicine (TCM) plays a variety of roles in inhibiting the proliferation, replication, adsorption and membrane penetration of the virus, promoting the expression of interferon in vivo, inhibiting inflammatory reaction, enhancing immunity, etc., which is one of the theoretical bases for the clinical application of TCM in the prevention and treatment of viral pneumonia. Traditional Chinese herbal medicine and compound medicinals are characterized by multi-component, multi-pathway and multi-pathway complex networks. Therefore, drug resistance is relatively rare in the clinical practice of TCM. Moreover, in the process of diagnosis and treatment of TCM, treatment based on differentiation of symptoms and signs, especially treatment based on classification of symptoms and signs, can best reflect the overall concept of TCM. TCM has precise therapeutic activity and less adverse reactions. Accumulating evidence has demonstrated the competent therapeutic effects of TCM against viral pneumonia with a prominent safety profile.

A Review Article published in 2020 in the journal Phytotherapy Research found that Star anise is the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu®), an antiviral medication for influenza A and influenza B. Besides, several other molecules with numerous biological benefits including the antiviral effects have been reported from the same plant. Except the antiviral potential, star anise possesses a number of other potentials such as antioxidant, antimicrobial, antifungal, anthelmintic, insecticidal, secretolytic, antinociceptive, anti-inflammatory, gastroprotective, sedative properties, expectorant and spasmolytic, and estrogenic effects.

A Review Article published in 2018 in the journal Molecules found that Tea catechins, found in green tea, may reduce the rates of influenza infection and diminish certain cold symptoms. The research methodology started with interpreting several experimental studies which reported that tea catechins can inhibit influenza viral adsorption and suppress replication and neuraminidase activity. These catechins were also found effective against some common cold viruses and helped to enhance immunity against such viral infections. Additionally, epidemiological studies conducted since the late 1990s were examined which suggested that regular consumption of green tea may decrease influenza infection rates and some cold symptoms, and gargling with tea catechin could potentially protect against the development of influenza infection. For the discussion of results, the studies collectively showed that tea catechins have potential antiviral activity against influenza and some cold viruses. Although clinical evidence supporting these effects remained unconclusive, the review showed promising trends. The consumption of green tea and gargling with tea catechins could lead to potentially decreased rates of influenza infection and lessened cold symptoms according to the analyzed epidemiological studies.

A Review Article published in 2018 in the journal Oxidative Medicine and Cellular Longevity found that Honey, a natural food supplement, emerges as a potent therapeutic antioxidant with diverse medicinal effects, including wound healing, antibacterial, anti-inflammatory, antifungal, antiviral, and antidiabetic properties, suggesting its potential as a novel antioxidant in managing oxidative stress-related diseases. The research extensively reviews honey's medicinal effects, emphasizing its role as a therapeutic antioxidant. The study explores various mechanisms, including the modulation of multiple signaling pathways and molecular targets. The evidence-based research underscores honey's role in alleviating diseases linked to oxidative stress. The reviewed pathways include caspase induction, cytokine stimulation, cell cycle regulation, and modulation of inflammatory markers. The comprehensive exploration of honey's therapeutic potential indicates its promise as a standalone or adjuvant antioxidant, necessitating further experimental and clinical investigation.

A published in 2015 in the journal BMC Complementary Medicine and Therapies found that Mung bean sprout extract has potent antiviral and to a lesser extent, prophylactic activities against both RSV and HSV-1, and in case of HSV-1, these activities were comparable to Acyclovir. MBS extract has potent antiviral and to a lesser extent, prophylactic activities against both RSV and HSV-1, and in case of HSV-1, these activities were comparable to Acyclovir. Part of the underlying mechanism(s) of these activities is attributed to MBS potential to remarkably induce antiviral cytokines in human cells. Hence, we infer that MBS methanol extract could be used as such or as purified active component in protecting and treating RSV and HSV-1 infections. More studies are needed to pinpoint the exact active components responsible for the MBS antiviral activities.

A Review Article published in 2014 in the journal Drug Design, Development and Therapy found that A mixture of active polysaccharides from Goji berries have shown multiple pharmacological activities, including anti-aging, antioxidative, anti-fatigue, anticancer, anti-diabetic, anti-viral, hepatoprotective, cardioprotective, neuroprotective, hypolipidemic, radioprotective, anti-osteoporosis, anti-inflammatory, and immunomodulating effects. The mechanisms for these beneficial effects are multifaceted, involving a number of signaling molecules and pathways. A better understanding of how LBPs act on these signaling pathways and molecules can improve our knowledge on glycobiology. Further studies using systems pharmacology approaches such as proteomic and metabolomic analysis are needed to uncover the molecular target networks of LBPs. Despite the importance of Goji in the traditional Chinese medicine and increased popularity in Western countries, clinical safety data on LBPs are sparse. A safe and optimal use of herbal medicines like LBPs requires a full understanding of their pharmacokinetics, side effects, and mechanisms of action. The dose–response and dose–toxicity relationships of LBPs should be established in animal and human studies. It is essential to develop new formulations to ensure the maximum efficacy and effectiveness and minimum side effects of LBP-related health products.

A Network Pharmacology published in 2014 in the journal Archives of Medical Research found that Manuka honey exhibits significant anti-influenza viral activity, inhibiting replication with virucidal effects. Combining manuka honey with existing drugs enhances their efficacy, suggesting its medicinal potential. This study aimed to address the urgent need for novel anti-influenza drugs by evaluating the anti-viral activity of honey, focusing on manuka honey. Antiviral activities were assessed using MDCK cells, revealing that manuka honey efficiently inhibited influenza virus replication with an IC50 of 3.6 ± 1.2 mg/mL and a CC50 of 82.3 ± 2.2 mg/mL, resulting in a selective index of 22.9. Virucidal effects were identified as the underlying mechanism. Furthermore, combining manuka honey with zanamivir or oseltamivir significantly enhanced their efficacy, showcasing the potential medicinal value of honey, particularly manuka honey, against the influenza virus. The study underscores the potent inhibitory activity of honey, especially manuka honey, against influenza viruses, offering promising medicinal implications. The observed virucidal effects and the synergistic enhancement of known anti-influenza drugs highlight the multifaceted potential of honey in combating influenza infections. Further exploration of the specific mechanisms underlying these effects could contribute to the development of effective anti-influenza therapies.

A Network Pharmacology published in 2014 in the journal Archives of Medical Research found that Honey, in general, and particularly manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value. Antiviral activities of honey samples were evaluated using MDCK cells. To elucidate the possible mechanism of action of honey, plaque inhibition assays were used. Synergistic effects of honey with known anti-influenza virus drugs such as zanamivir or oseltamivir were tested. Manuka honey efficiently inhibited influenza virus replication (IC50 = 3.6 ± 1.2 mg/mL; CC50 = 82.3 ± 2.2 mg/mL; selective index = 22.9), which is related to its virucidal effects. In the presence of 3.13 mg/mL manuka honey, the IC50 of zanamivir or oseltamivir was reduced to nearly 1/1000th of their single use.

A Systematic Review published in 2013 in the journal Cochrane Database of Systematic Reviews found that Most Chinese medical herbs in the included studies showed similar effects to antiviral drugs in preventing or treating influenza. This updated review assessed the therapeutic effects and safety of Chinese medicinal herbs as an alternative and adjunctive therapy to other commonly used drugs for influenza. Eighteen studies involving 2521 participants were included in the review. 'Ganmao' capsules were found to be more effective than amantadine in decreasing influenza symptoms and aiding recovery in one study (in which adverse reactions were mentioned in the amantadine group although no data were reported). There were no significant differences between 'E Shu You' and ribavirin in treating influenza, nor in the occurrence of adverse reactions. The remaining 17 Chinese herbal trials showed a similar effect to antiviral drugs in preventing or treating influenza. However, since these included studies were of poor quality, the evidence does not support or reject the use of any Chinese herbal preparations for influenza. High‐quality trials are required.

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