Erythropoietin

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Chinese Medicine Research Hub

Review Article

Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.

2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
Chen J, Tsim KWK

Chinese Medicine Research Hub

Review Article

Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.

2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
Chen J, Tsim KWK

Chinese Medicine Research Hub

Animal Study

Jian-Pi-Yi-Shen, a traditional Chinese medicine, helps treat anemia in chronic kidney disease by stimulating erythropoietin production and regulating iron recycling.

2020 Evidence-Based Complementary and Alternative Medicine Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2α via ERK Signaling
Wang F, Yu H, Huang S, Zheng L, Zheng P, Zhang S, Li S, Chen J

Chinese Medicine Research Hub

Theoretical Article

The Chinese herbal formula Jian-Pi-Yi-Shen can enhance the immune system, treat anemia, and regulate erythropoietin and pro-inflammatory cytokines expression.

2018 BMC Complementary Medicine and Therapies A Chinese herbal decoction, Jian-Pi-Yi-Shen, regulates the expressions of erythropoietin and pro-inflammatory cytokines in cultured cells
Chen J, Gong AGW, Liu X, Li Z, Qi A, Dong TTX, Yi T, Tsim KWK, Li S

Chinese Medicine Research Hub

Experimental Study

Angelica sinensis polysaccharide (ASP) efficiently stimulates erythropoietin secretion and suppresses the liver's hepcidin expression, potentially aiding in treatments of hepcidin-induced diseases.

2011 Journal of Ethnopharmacology Inhibitory effect of polysaccharides isolated from Angelica sinensis on hepcidin expression
Wang KP, Zeng F, Liu JY, Guo D, Zhang Y

Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Erythropoietin" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Erythropoietin" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2020 in the journal Frontiers in Pharmacology found that Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production. Jujube promotes erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, possesses potential capacity in recycling heme iron during erythrophagocytosis, exhibits bidirectional role in regulating immune response under different conditions, contains numerous minerals including iron.

A Review Article published in 2020 in the journal Frontiers in Pharmacology found that Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties. Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. Thus, the blood-nourishing function of jujube is being proposed here. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia.

A Animal Study published in 2020 in the journal Evidence-Based Complementary and Alternative Medicine found that Jian-Pi-Yi-Shen, a traditional Chinese medicine, helps treat anemia in chronic kidney disease by stimulating erythropoietin production and regulating iron recycling. To investigate the effect of Jian-Pi-Yi-Shen (JPYS), chronic kidney disease (CKD) was experimentally induced in rats using a 5/6 nephrectomy. The rats were then administered JPYS orally in both high and low doses for a period of 90 days. Observations were made regarding the serum hepcidin level to assess iron homeostasis. Additionally, the protein expressions of hypoxia inducible factor-2, erythropoietin, ferritin, ferroportin, and the phosphorylation level of extracellular signal-regulated kinase 1/2 were studied using Western blot analysis. The results showed that JPYS treatment significantly improved kidney function in the CKD rats. Alongside this, pathological kidney damage was found to be significantly restored post-JPYS treatment. The medicine was found to be effective in improving anemia in CKD through the upregulation of red blood cells, hemoglobin, and hematocrit levels. It was also discovered that JPYS stimulates the expressions of erythropoietin and hypoxia-inducible factor-2 proteins in the kidney and liver of the CKD rats, while inducing the phosphorylation of extracellular signal-regulated kinase 1/2 proteins. Furthermore, JPYS was seen to regulate the protein expressions of ferritin and ferroportin in the liver and spleen, as well as in the serum level of hepcidin, suggesting its role in systemic iron recycling.

A Theoretical Article published in 2018 in the journal BMC Complementary Medicine and Therapies found that The Chinese herbal formula Jian-Pi-Yi-Shen can enhance the immune system, treat anemia, and regulate erythropoietin and pro-inflammatory cytokines expression. In the study, the Jian-Pi-Yi-Shen (JPYS) herbal extracts were applied onto cultured cells for 24 to 48 hours. Total RNA was collected from these treated cells for real-time quantitative PCR analysis. Additionally, the standardized herbal extracts were treated with transfected HEK293T cells which were composed of a hypoxia response element tagged with a luciferase gene. In one experiment, the treatment of JPYS extracts onto the cultured cells induced erythropoietin expression in a dose-dependent manner, showing a prominent increase. In another experiment, after the application of JPYS extract for 24 hours, the expressions of interleukin and tumor necrosis factor in cultured macrophages were stimulated. However, when the macrophages were pre-treated with the JPYS extract, the expression of the same cytokines was suppressed in lipopolysaccharide-induced macrophages. So, apart from supporting the hematopoietic function by regulating erythropoietin expression, this study demonstrated that the Chinese herbal formula, Jian-Pi-Yi-Shen, also plays a crucial role in immune-modulation, specifically in regulating the expression of pro-inflammatory cytokines in culture.

A Experimental Study published in 2011 in the journal Journal of Ethnopharmacology found that Angelica sinensis polysaccharide (ASP) efficiently stimulates erythropoietin secretion and suppresses the liver's hepcidin expression, potentially aiding in treatments of hepcidin-induced diseases. In observing the effects of ASP, a substance derived from a plant used in traditional Chinese medicine, the researchers administered the substance daily to rats through intragastric methods for a period of 14 days. Apart from this, a group of positive control rats also received injections of recombinant human erythropoietin. The researchers then monitored the levels of erythropoietin and hepcidin in the serum at various times using an enzyme-linked immunosorbent assay. Additionally, the researchers used the Western blot method to examine the expression of six key signal proteins in the liver. The results revealed that ASP notably diminished the liver's expression of hepcidin, a factor known for negatively regulating the body's iron metabolism. This reduction was primarily facilitated through inhibiting the expression of specific liver proteins (STAT3/5 and SMAD4) and stimulating the secretion of erythropoietin. This stimulation led to further down-regulation of hepcidin, a process aided by reducing the liver's expression of other proteins (C/EBPα, SMAD4, and the phosphorylation process of STAT3/5). Hence, the research suggests ASP can effectively suppress hepcidin expression in normal rats.

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