Peptic Ulcer

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Chinese Medicine Research Hub

Meta-Analysis

Acupuncture combined with Chinese herbal medicine is more efficacious in treating gastric ulcers than just Chinese herbal medicine alone.

2026 Medicine The efficacy of acupuncture combined with Chinese herbal medicine in the treatment of gastric ulcer: A systematic review and meta-analysis
Liang YF, Qu WW, Zhu MD, Liu GF, Zheng X, Jiang Q, Han YL, Wang Q

Chinese Medicine Research Hub

Meta-Analysis

Chinese patent medicines, namely WWSC, PWC, WFCT, and KFXS, combined with Western medicines, show improved effectiveness in treating Helicobacter pylori-related gastric ulcers.

2025 Medicine A comparison of the efficacy and safety of Chinese patent medicine combined with Western medicine for Helicobacter pylori-related gastric ulcer: A systematic review and network meta-analysis
Zhong M, Sun Q, Ren B, Yu C, Zhou S, Gao Q, Wang X, Yuan C, Lu J, Peng Q, Zeng M, Song H

Chinese Medicine Research Hub

Anweiyang capsule and Pinellia Heart-Draining Decoction improves Helicobacter pylori eradication, ulcer healing rate, and traditional Chinese Medicine syndromes in peptic ulcer patients, with a lower risk of adverse reactions.

2024 AMB Express Clinical effects of anweiyang capsule and Pinellia decoction for eradication of Helicobacter pylori and healing of peptic ulcers
Feng X, Zhao X, Cao L, Shang R, Feng X

Chinese Medicine Research Hub

Meta-Analysis

Combination therapies with Chinese patent medicines, particularly Jianweiyuyang and Kangfuxin, show promise for treating peptic ulcers.

2024 BMJ Open Efficacy and safety of seven Chinese patent medicines combined with conventional triple/quadruple therapy forHelicobacter pylori-positive peptic ulcers: a systematic review and network meta-analysis
Jiang Z, Deng B, Zhang Y, Li Y, Yu Z, Deng H, Chen Y

Chinese Medicine Research Hub

Review Article

Peptic ulcers may be prevented and cured by well-chewed food rich in vegetable fibers and fermented milk products, which increase protective salivary mucus and decrease damaging bile flow.

2024 Psychoneuroendocrinology New approaches to the pathogenesis of peptic ulcer based on the protective action of saliva with special reference to roughage, vegetable fibre and fermented milk products
Malhotra SL

Chinese Medicine Research Hub

Meta-Analysis

Combining conventional triple therapy with the Chinese herb formula Xiangsha Liujunzi significantly improves the treatment of Helicobacter pylori-positive peptic ulcer disease.

2022 Phytomedicine Evidence construction of Chinese herbal formulae for the treatment of H. pylori positive peptic ulcer: A Bayesian network Meta-analysis
Yang J, Yang H, Dai Y, Jiang Y, Long Y, Zeng J, Ma X

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Peptic Ulcer" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Peptic Ulcer" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Peptic Ulcer" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Meta-Analysis published in 2026 in the journal Medicine found that Acupuncture combined with Chinese herbal medicine is more efficacious in treating gastric ulcers than just Chinese herbal medicine alone. In this study, a broad search was executed in both Chinese and international databases to locate relevant randomized controlled trials (RCTs) examining the effectiveness of acupuncture, in conjunction with Chinese herbal medicine, as a treatment for gastric ulcers. Criteria such as efficacy rates, recurrence rates, eradication rate of Helicobacter pylori, gastrin levels, and adverse events were taken into account. Using an established risk assessment tool, each study was evaluated for quality before the collated data was analyzed using dedicated software. In the study's results, it was found that a total of 17 RCTs, encompassing 1632 patients, met eligibility requirements for the meta-analysis. The results indicated that the use of acupuncture in tandem with Chinese herbal medicine surpassed non-acupuncture Chinese medicine approaches in several measures. These included overall efficacy, eradication rate of Helicobacter pylori, recurrence rate, and gastrin levels, implying that acupuncture may be an effective complementary therapy. Additionally, there was no reported increase in adverse events, pointing towards a seemingly favorable safety profile in clinical applications.

A Meta-Analysis published in 2025 in the journal Medicine found that Chinese patent medicines, namely WWSC, PWC, WFCT, and KFXS, combined with Western medicines, show improved effectiveness in treating Helicobacter pylori-related gastric ulcers. A comprehensive search was conducted to identify randomized controlled trials (RCTs) that examined the effectiveness of Chinese patent medicines (CPMs) in combination with conventional Western medicines (WMs) in treating patients with H pylori-related gastric ulcers. Various sources were used for this search from their inception up to May 2023. The methodological quality of the RCTs was then measured using the Cochrane risk of bias assessment tool. Using R version 4.2.3 and Stata version 15.1 software, a pairwise network meta-analysis was performed. The analysis found a total of 35 studies involving 4667 patients and 11 different CPMs. The results demonstrated that the combination of CPM and WM was more effective than the WM regimen alone. Certain combinations, specifically WWSC combined with WM, PWC combined with WM, WFCT combined with WM, and KFXS combined with WM, proved to have superior results in enhancing clinical outcomes and mitigating gastric ulcer recurrence rates, improving the H. pylori eradication rate, controlling certain bodily levels, and reducing the incidence of adverse events, respectively.

A published in 2024 in the journal AMB Express found that Anweiyang capsule and Pinellia Heart-Draining Decoction improves Helicobacter pylori eradication, ulcer healing rate, and traditional Chinese Medicine syndromes in peptic ulcer patients, with a lower risk of adverse reactions. The study randomly divvied up 100 patients suffering from peptic ulcers into two groups: an observation group and a control group. The observation group, consisting of 50 patients, were administered with a blend of Anweiyang capsule and Pinellia Heart-Draining Decoction, two herbal treatments. The other 50 patients, comprising the control group, were subjected to standard Western medical treatment. After a period of four weeks, both treatment groups showed a decrease in serum procalcitonin and C-reactive protein levels, alongside an increase in prostaglandin E2 levels. However, the observation group, those treated with the herbal combination, showed budding signs of improvement. The observation group achieved a considerably higher rate of Helicobacter pylori eradication, alongside an increased healing rate for ulcers. Similarly, this group also portrayed a greater improvement in symptoms related to traditional Chinese Medicine syndromes. Despite these positive results, the rate of adverse reactions remained significantly lower in the observation group compared to the control counterpart.

A Meta-Analysis published in 2024 in the journal BMJ Open found that Combination therapies with Chinese patent medicines, particularly Jianweiyuyang and Kangfuxin, show promise for treating peptic ulcers. In studying the efficacy and safety of seven Chinese patent medicines added to standard therapies for peptic ulcers, a systematic review and network meta-analysis were employed. These medicines included capsules, tablets, granules, and liquids with distinct names extracted from multiple databases such as China National Knowledge Infrastructure, VIP database, Wanfang database, ScienceDirect, EBSCO, EMBASE, Web of Science, Cochrane Library and PubMed. The focus was on trials involving these medications combined with conventional triple/quadruple therapy, with recorded outcomes like complete ulcer healing rate, effective rate, eradication rate, rate of peptic ulcer recurrence and incidence of adverse reactions. A total of 36 randomised controlled trials involving 3620 patients were included in the findings. The results showed that compared to conventional therapy alone, combinations involving Weisu, Weifuchun, and Puyuanhewei exhibited the highest rates of complete ulcer healing, effectiveness, and eradication, respectively. Additionally, the lowest recurrence rates were observed with Weisu and Jianwaiyuyang. Meanwhile, the lowest incidence of adverse reactions was recorded with Jianweiyuyang. Cluster analysis further indicated Jianweiyuyang as the most advantageous choice, given its simultaneous efficacy and safety measures, followed by Kangfuxin.

A Review Article published in 2024 in the journal Psychoneuroendocrinology found that Peptic ulcers may be prevented and cured by well-chewed food rich in vegetable fibers and fermented milk products, which increase protective salivary mucus and decrease damaging bile flow. The research conducted a review of epidemiologic studies focusing on the variations of diet and eating patterns related to the prevalence of peptic ulcer disease across various communities. The effects of dietary patterns were assessed on saliva, gastric juice, and bile. The role of bile was specifically examined in the pathogenesis of peptic ulcer, with the argument that it, rather than hydrochloric acid, played a causal role. The role of saliva in preventing peptic ulcers was emphasized, particularly the protective nature of salivary mucus which is swallowed with food. The study then suggested the types of diets that can help prevent peptic ulcers, including those rich in roughage, cellulose, vegetable fibers, and fermented milk products such as ghee and yogurt. The research posited this kind of diet can increase the amount of salivary mucus and consequently decrease the flow rate of harmful bile. The study also noted that these insights showed minor changes in diet, and a slower pace of consumption could lead to substantial health benefits. Moving from dietary composition to eating behaviors, it was suggested that food should be well-masticated to ensure these beneficial digestive processes have an opportunity to occur. At the same time, the research made the case that specific dietary components, particularly short-chain fatty acids like those found in milk products, can retard gall bladder contraction, thereby reducing the amount of bile entering the duodenal lumen. This secondary action further contributes to the potential prevention of peptic ulcers.

A Meta-Analysis published in 2022 in the journal Phytomedicine found that Combining conventional triple therapy with the Chinese herb formula Xiangsha Liujunzi significantly improves the treatment of Helicobacter pylori-positive peptic ulcer disease. The methodology for this research included a review of fifty-one randomized controlled trials, involving 5172 patients and ten therapeutic strategies, found across eight medical-literature databases. Software such as Review Manager, R Project and STATA16.0 were utilized to conduct a Bayesian network Meta-analysis, with the primary outcome indicator being the eradication rate of H. pylori. Secondary indicators were the clinical effectiveness rate, recurrence rate and adverse reaction reports. Discussion of the results reveals that the supplementing conventional triple therapy with Chinese herbal formulae increased the eradication rate and clinical efficiency, and reduced the recurrence rate of H. pylori more effectively than standalone conventional triple therapy treatments. The combination therapy, specifically with Xiangsha Liujunzi, emerged as the most effective amongst the ten treatments examined, underlining the potential merit of integrating Chinese herbal formulae with conventional treatments when combating H. pylori-positive peptic ulcer disease. No significant safety issues emerged from the combination therapy.

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