Insights & Discussion
The supplementary intake of green tea does not significantly affect blood glucose, fasting insulin, hemoglobin A1c, and insulin resistance in patients with type 2 diabetes mellitus.
To examine the impact of green tea consumption on type 2 diabetes mellitus patients, a comprehensive search for relevant randomized controlled trials was conducted across multiple databases, including Web of Science, PubMed, and Scopus, without any language or time restrictions until June 2019. Both random and fixed effects models were utilized in the subsequent meta-analysis, with the I2 index employed to assess heterogeneity.
The initial search resulted in 780 relevant publications, from which 14 were selected for analysis. The evaluation revealed that additional intake of green tea had negligible influence on fasting plasma glucose, fasting insulin, hemoglobin A1c, and insulin resistance indicators in individuals affected by type 2 diabetes mellitus. This conclusion is drawn from a distinct pool of research without insisting further study or discussing numerical specifics and probabilities.
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Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency.
2023 Nutrients Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women Siblini H, Al-Hendy A, Segars J, González F, Taylor HS, Singh B, et al.
Cohort Study EGCG Green Tea Uterine Fibroids
The study involved the pre-testing of a green tea substance known as Epigallocatechin gallate (EGCG) on a cohort of premenopausal women, aged 18 to 40, with and without uterine fibroids, in order to evaluate its safety. The subjects were randomized into three groups, each receiving different treatments. One group took just a daily dose of 800 mg of EGCG, one group combined this EGCG dose with 100 mg of Clomiphene citrate for five days, and the third group combined it with 5 mg of Letrozole for the same period.
The results showed that none of the subjects displayed signs of drug-induced liver injury, and all had normal serum folate levels. Hence, the findings suggest that the daily intake of 800mg of EGCG, whether consumed alone or in combination with Clomiphene citrate or Letrozole for five days, is well-tolerated and not related to any liver toxicity or folate deficiency in women of reproductive age.
Heavy coffee consumption increases the risk of cardiovascular disease mortality in individuals with severe hypertension, while green tea consumption does not.
2023 Journal of the American Heart Association Coffee and Green Tea Consumption and Cardiovascular Disease Mortality Among People With and Without Hypertension Teramoto M, Yamagishi K, Muraki I, Tamakoshi A, Iso H
Cohort Study Green Tea High Blood Pressure
With the use of the Japan Collaborative Cohort Study, researchers assessed 18,609 participants, both male and female, aged between 40 to 79 years. These participants had varying blood pressure levels, categorized into optimal and normal BP, high-normal BP, and two stages of hypertension. They completed a questionnaire about their lifestyle, diet, and medical history, and underwent health examinations, which were followed up until 2009. The association of coffee and green tea consumption on cardiovascular disease mortality was then calculated using a Cox proportional hazard model.
It was found over an 18.9 year follow-up period that heavy coffee consumption was linked to increased risk of cardiovascular disease mortality among those suffering from the second to third grade of hypertension. In stark contrast, people with optimal and normal, high-normal blood pressure and first grade hypertension did not show such associations between coffee consumption and cardiovascular disease mortality. Interestingly, the risk of cardiovascular disease mortality was not found to be increased across any blood pressure categories in relation to green tea consumption.
The combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.
2023 Journal of Personalized Medicine The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report Grandi G, Botticelli L, Fraia PD, Babalini C, Masini M, Unfer V
Case Report Cervical Dysplasia Cervical Lesions EGCG
The methodology used in this research centred around treating a 39-year-old patient who had a history of HPV, cervix lesions, and multiple failed surgical attempts to treat the condition. The treatment plan applied was unique, utilizing a blend of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid, administered over an eight week period.
The results showed promising effects, with the patient's histological and cytological analyses revealing only a chronic cervicitis instead of any malignant lesions or cellular dysplasia. Therefore, the necessity for invasive total hysterectomy was minimized, demonstrating the potential for the selected treatment plan to manage precancerous lesions of the uterine cervix.
Long-term consumption of green tea can potentially lessen the risk of depression in postmenopausal women by decreasing inflammation and boosting estradiol levels.
2023 Nutrients Long-Term Consumption of Green Tea Can Reduce the Degree of Depression in Postmenopausal Women by Increasing Estradiol Wan Z, Qin X, Tian Y, Ouyang F, Wang G, Wan Q
Cohort Study Anti-Inflammatory Green Tea Oestradiol
In the study, researchers performed an analysis on a tea-producing village, incorporating 386 postmenopausal women in the investigation, who participated either as green tea consumers or non-drinkers (control group). The level of estradiol, inflammation markers, sleep quality, and depression symptoms were measured to uncover any correlations.
The results reflected significant disparities between the tea-drinking and control groups in terms of depression and insomnia levels, BMI, inflammation levels, and estradiol quantities. By appraising these outcomes, it was found that green tea intake could quell the likelihood of depression via its impact on sleep, inflammation, and estradiol levels. The risk of depression was consequently seen as reduced among postmenopausal women engaging in regular consumption of green tea.
Extra virgin olive oil (EVOO) has beneficial health properties and can promote cardiovascular health, lipoprotein metabolism, and diabetes management in clinical nutrition.
2022 Nutrients Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update Jiménez-Sánchez A, Martínez-Ortega AJ, Remón-Ruiz PJ, Piñar-Gutiérrez A, Pereira-Cunill JL, García-Luna PP
Review Article Cardiovascular Disease Type 2 Diabetes
The methodology of this narrative review involved an extensive synthesis and illustration of the various characteristics and clinical applications of EVOO and its components such as oleic acid, hydroxytyrosol, and oleuropein. It looked at their significance in diet therapy, use in oleic acid-based enteral and parenteral nutrition formulations, and oral supplementation formulations.
In their discussion of the results, the researchers found diverse health benefits associated with EVOO. Particularly, they highlighted the potential of whole EVOO in diet therapy and its minor components in supplementation to enhance cardiovascular health, control lipoprotein metabolism, and manage diabetes mellitus within a clinical nutrition framework. It was seen as a significant addition to nutritional and dietary strategies, with a potential for therapeutic application in several diseases and clinical demographics.
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