Insights & Discussion
The ethanol extract of FCI potentially counters bone loss in mice by enhancing osteoblast proliferation and differentiation, facilitated by multiple bioactive compounds.
In this study, the researchers scrutinized the antiosteoporosis potential of the ethanol extract of FCI in mice experiencing bone loss due to ovariectomy, a process likened to human menopause. In the process, the antiosteoporosis fraction derived from FCI was isolated and cleansed using a technique known as high-speed countercurrent chromatography, which resulted in the successful isolation of the principle bioactive compounds.
The researchers found that, among the separations, the ethyl acetate fraction exhibited remarkable antiosteoporosis activity. Upon further analysis, the foremost compounds were identified as acacetin, apigenin, luteolin, and linarin. Furthermore, these compounds were found to stimulate the proliferation and differentiation of osteoblasts - the cells responsible for bone formation. The process was potentially mediated by the activation of the AKT signaling pathway and the upregulation of certain genes such as Runx2, OCN, OPN, and COL I. The collective efforts of these bioactive compounds played a crucial role in the observed antiosteoporosis effects, suggesting that the effectiveness of FCI is not reliant on a single component, but an ensemble of elements working in tandem.
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The compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside from chrysanthemum flowers demonstrated superior antioxidant and anti-osteoporosis effects.
2023 Journal of Science and Technology - HaUI Investigate the antioxidant and anti-osteoporosis activities of compounds isolated from chrysanthemum indicum flowers Le The Hoai, Nguyen Thi Huong, Bui Thi Thu Trang
Experimental Study Antioxidant Chrysanthemum Osteoporosis
The research involved isolating five compounds from Chrysanthemum indicum L flowers: Syringin, Dihydrosyringin, Benzyl-O-β-D- glucopyranoside, -Phenylethoxy-O--D-glucopyranoside, and (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside. The identification and structure determination of these compounds were performed via the interpretation of their 1D - NMR spectra and comparison to established literature. The collected compounds were then assessed for their antioxidative and anti-osteoporosis activities.
During the analysis of results, it was observed that the compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside exhibited significantly higher antioxidant activity and anti-osteoporosis effects compared to the others. It showed a strong capacity for peroxyl radical scavenging, surpassing the protection offered by the standard Trolox. Dihydrosyringin also demonstrated a good reducing capacity, as indicated by its CUPRAC values. Furthermore, (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside displayed strong inhibitory effects on osteoclast differentiation, indicating its potential as an anti-osteoporosis agent.
Chrysanthemum coronarium L. extract can both stimulate bone building cells and inhibit bone breaking cells, so has potential as a natural treatment for osteoporosis.
2020 Evidence-Based Complementary and Alternative Medicine Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo Kim SA, Lee AS, Hur HJ, Lee SH, Sung MJ
Experimental Study Chrysanthemum Osteoporosis
The study examined the effects of Chrysanthemum coronarium L. extracts on in vitro cell cultures and animal models with bone loss. This was done by observing the increase and decrease of bone formation markers in different cell lines, specifically the murine preosteoblastic cell line MC3T3-E1, and the murine macrophage-like cell line RAW264.7 respectively.
The results showed that the extract stimulated the differentiation of osteoblasts, cells responsible for bone formation, and inhibited osteoclast differentiation, cells that break down bone. In osteoporotic animal models, the extract prevented bone loss, preserved the structure of the small bones and improved serum bone turnover markers. This implies that the extract has promising potential as a natural therapy for osteoporotic bone loss.
Chrysanthemum, a plant primarily grown in China and Japan, offers significant health benefits including stress reduction, cardiovascular improvement, and lowering osteoporosis risk.
2019 Applied Ecology and Environmental Research A REVIEW OF CHRYSANTHEMUM, THE EASTERN QUEEN IN TRADITIONAL CHINESE MEDICINE WITH HEALING POWER IN MODERN PHARMACEUTICAL SCIENCES SHAHRAJABIAN MH
Theoretical Article Cardiovascular Disease Chrysanthemum Osteoporosis
The study focused on Chrysanthemum, a notable plant in the ornamental industry and traditional Chinese medicine, mainly grown in China and Japan. The researchers identified its crucial chemical extracts such as flavonoids, betaine, choline, and vitamin B1. They additionally pinpointed thirteen significant compounds of chrysanthemum flowers, including acacetin-7-0-beta- D-glucopyranoside, luteolin, acaciin, and boscialin, among others.
The findings revealed that chrysanthemum tea exhibits considerable health advantages. It eases stress and anxiety, enhances cardiovascular health, protects against oxidative damage, inhibits inflammation, supports healthy immune function, ameliorates eye health, and decreases the risk for osteoporosis. In traditional Chinese medicine, chrysanthemum is considered a cold herb that dispels pathogenic heat, aids the liver, improves eyesight, and promotes detoxification. The study, therefore, endorsed the treatment with natural Chinese herbal medicine, especially chrysanthemum, over synthetic drugs for a more organic life.
Two new compounds found in Chrysanthemum indicum flowers have strong antioxidant qualities and are potent in anti-osteoporosis activity.
2015 Phytotherapy Research The Anti‐Osteoporosis and Antioxidant Activities of Chemical Constituents from Chrysanthemum indicum Flowers Luyen BTT, Tai BH, Thao NP, Lee YM, Lee SH, Jang HD, et al.
Experimental Study Antioxidant Chrysanthemum Osteoporosis
The research involved the isolation of two new compounds from Chrysanthemum indicum flowers, alongside 17 known compounds. Each compound was then measured for total phenolic and flavonoid content. The research demonstrated the highest concentration of these beneficial compounds within the Ethyl Acetate (EtOAc) fraction of the sample. An assessment of the antioxidative potential of each compound was conducted next, mainly focusing on their peroxyl radical-scavenging capacity and their ability to reduce copper ions.
The results confirmed that the two new compounds discovered displayed strong antioxidative effects. These compounds also showed promising activity against tartrate-resistant acid phosphatase in receptor activator of the nuclear factor in osteoclastic cells, suggesting potential efficacy as agents in combatting osteoporosis. Beyond these new compounds, several other compounds isolated from the Chrysanthemum indicum also demonstrated strong antioxidative and anti-osteoporotic activity.