Chronic Stress
Recent Insights
Pumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress.
Chronic Stress Depression Fluoxetine
Pomegranate extract intake, rich in biophenols, lessens salivary cortisol levels, hence potentially improving health-related quality of life, particularly in stress-suffering individuals.
Biophenols Chronic Stress Cortisol
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula
2022 Jan Journal of Integrative Medicine Chen S, Hu J, Lu D, Liu H, Wei S
These findings expose the metabolomic disturbances induced by chronic stress in Spontaneously hypertensive rats (SHRs) and suggest an innovative treatment for this disorder.
Animal Study Stress Jia Wei Xiao Yao SanL. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus
2021 Jul 10 Oxidative Medicine and Cellular Longevity Ayuob N, Shaker SA, Hawuit E, Al-Abbas N, Shaer NA, Al Jaouni S, et al.
Animal Study Pumpkin Seed Stress Fluoxetine Chronic Stress DepressionPumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress.
Intranasal use of lavender and fennel decreases salivary cortisol levels and improves quality of sleep: A double-blind randomized clinical trial
2020 Feb European Journal of Integrative Medicine Polonini H, Mesquita D, Lanine J, Dijkers E, Gkinis S, Raposo NRB, et al.
Randomised Controlled Trial Cortisol Lavender SleepIntranasal application of essential oils such as lavender and fennel (Pinetonina™) significantly lowers cortisol levels and improves sleep quality.
Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats
2016 Apr Neuroscience Letters Lu J, Shao RH, Hu L, Tu Y, Guo JY
Acupuncture treatment, along with fluoxetine, reversed CUMS-induced depressive-like behavior in rats, and this effect was associated with a significant decrease in the levels of proinflammatory cytokines (IL-1β, IL-6, TNF-α) in the hippocampus, prefrontal cortex, and serum.
Experimental Study Animal Study Acupuncture Chronic StressBiophenols-rich pomegranate extract intake inhibits salivary cortisol and 11[beta]-HSD1 activity and improves overall quality of life scores in healthy volunteers
2014 Mar 01 Endocrine Abstracts Stockton A, Al-Dujaili E
Randomised Controlled Trial Cortisol Chronic Stress Stress Pomegranate High Blood Pressure BiophenolsPomegranate extract intake, rich in biophenols, lessens salivary cortisol levels, hence potentially improving health-related quality of life, particularly in stress-suffering individuals.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Pumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress.
2021 Oxidative Medicine and Cellular Longevity L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus Ayuob N, Shaker SA, Hawuit E, Al-Abbas N, Shaer NA, Al Jaouni S, et al.
Animal Study Depression Fluoxetine Pumpkin Seed
The researchers used forty male albino rats, split into four different groups: a negative control group, a chronic unpredictable mild stress (CUMS) group, a fluoxetine-treated group, and a pumpkin-treated group. These rats were exposed to CUMS for 28 days, with the treatments applied during the last 14 days of this exposure period. After these 28 days, the scientists evaluated the behavioral, biochemical, and histopathological alterations in these rats.
The application of pumpkin extract significantly reduced markers of stress and inflammation, while increasing antioxidant levels. Additionally, the extract helped reduce structural damage in the hippocampal region of the brain caused by exposure to CUMS. These effects were comparable to those observed by administering fluoxetine, a conventional antidepressant.
Intranasal application of essential oils such as lavender and fennel (Pinetonina™) significantly lowers cortisol levels and improves sleep quality.
2020 European Journal of Integrative Medicine Intranasal use of lavender and fennel decreases salivary cortisol levels and improves quality of sleep: A double-blind randomized clinical trial Polonini H, Mesquita D, Lanine J, Dijkers E, Gkinis S, Raposo NRB, et al.
Randomised Controlled Trial Cortisol Lavender Sleep
The study included 45 participants divided into three groups: one group received a saline nasal spray (Group 1 CTRL), the second group received a 30% concentration of Pinetonina™ in a buffered vehicle as an intranasal spray (Group 2 P30), and the third group received a 50% concentration of the same (Group 3 P50). The sprays were used once daily before bedtime for three months. The study measured salivary cortisol levels both at the beginning and end of the trial and assessed subjects' quality of sleep, anxiety levels, perceived stress, and overall quality of life using self-reported questionnaires.
The study found that the groups using the 30% and 50% Pinetonina™ solutions saw significant reductions in their cortisol levels after the three-month period. The subjects in the 50% Pinetonina™ group also reported a notable improvement in their quality of sleep. However, there were no significant differences among the groups' perceived stress levels and their overall quality of life. Nevertheless, the study concluded that nightly intranasal use of Pinetonina™ could effectively lower cortisol levels and enhance sleep quality.
Pomegranate extract intake, rich in biophenols, lessens salivary cortisol levels, hence potentially improving health-related quality of life, particularly in stress-suffering individuals.
2014 Endocrine Abstracts Biophenols-rich pomegranate extract intake inhibits salivary cortisol and 11[beta]-HSD1 activity and improves overall quality of life scores in healthy volunteers Stockton A, Al-Dujaili E
Randomised Controlled Trial Biophenols Cortisol High Blood Pressure
The study was conducted using a double-blind, randomized, placebo-controlled parallel trial. Participants, ranging in age and body mass index, took either a pomegranate extract capsule or a placebo each day for a duration of 4 weeks. The extracted capsule, which contained a high concentration of biophenols, was consumed with water after a meal. In addition to tracking dietary practices and habits, health related Quality of Life was recorded before and after the study. To assess the effects, salivary cortisol and cortisone levels were measured at three distinct points in the day.
In the results, there was a notable decrease in the salivary cortisol levels of participants who consumed these pomegranate extract capsules. Alongside this, the ratio of cortisol to cortisone was significantly minimized. The participants' physical and social functionality, pain levels, and overall well-being showed significant improvement during the study. Conversely, there was a slight increase in the salivary cortisol and ratio of cortisol to cortisone for participants who took the placebo.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Intranasal use of lavender and fennel decreases salivary cortisol levels and improves quality of sleep: A double-blind randomized clinical trial
2020 Feb European Journal of Integrative Medicine Polonini H, Mesquita D, Lanine J, Dijkers E, Gkinis S, Raposo NRB, et al.
Randomised Controlled Trial Cortisol Lavender SleepIntranasal application of essential oils such as lavender and fennel (Pinetonina™) significantly lowers cortisol levels and improves sleep quality.
Biophenols-rich pomegranate extract intake inhibits salivary cortisol and 11[beta]-HSD1 activity and improves overall quality of life scores in healthy volunteers
2014 Mar 01 Endocrine Abstracts Stockton A, Al-Dujaili E
Randomised Controlled Trial Cortisol Chronic Stress Stress Pomegranate High Blood Pressure BiophenolsPomegranate extract intake, rich in biophenols, lessens salivary cortisol levels, hence potentially improving health-related quality of life, particularly in stress-suffering individuals.
Presentation Slides
Pumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress.
Intranasal application of essential oils such as lavender and fennel (Pinetonina™) significantly lowers cortisol levels and improves sleep quality.
Pomegranate extract intake, rich in biophenols, lessens salivary cortisol levels, hence potentially improving health-related quality of life, particularly in stress-suffering individuals.
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