Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
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Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Zeaxanthin dipalmitate, a wolfberry-derived carotenoid, can delay retinal degeneration in mice modelling Retinitis Pigmentosa mainly through its anti-inflammatory and oxidative stress effects.
Experimental Study Goji Berry Retinitis Pigmentosa
In the study's methodology, Zeaxanthin dipalmitate (ZD) was intravitreally injected into mice on postnatal day 16. Subsequent assessment of retinal function and structure were made at P25 using visual behavior tests, multi-electrode-array recordings, and immunostaining. The involved gene expressions and their regulation by ZD were delved into through transcriptome sequencing and western blotting.
In the discussion of results, it was discovered that ZD treatment significantly improved the visual behavior of the mice and delayed degeneration of the retinal photoreceptors, enhancing the light responses of photoreceptors, bipolar cells, and retinal ganglion cells. The ZD treatment led to a decline of up-regulated genes connected to inflammation, apoptosis, and oxidative stress. The study found that ZD reduces the activation of signal transducer and activator of transcription 3 and chemokine ligand 2, down-regulates the expression of the inflammatory factor GFAP, and withholds extracellular signal regulated protein kinases and P38, but not JNK pathways. All these findings indicate the potential of ZD as treatment for Retinitis Pigmentosa.
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Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Chinese Medicine Research Hub
Experimental Study
Zeaxanthin dipalmitate, a wolfberry-derived carotenoid, can delay retinal degeneration in mice modelling Retinitis Pigmentosa mainly through its anti-inflammatory and oxidative stress effects.
2021 Journal of Neurochemistry Wolfberry‐derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways
Liu F, Liu X, Zhou Y, Yu Y, Wang K, Zhou Z, Gao H, So KF, Vardi N, Xu Y
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Retina degeneration" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Retina degeneration" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Retina degeneration" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Experimental Study published in 2021 in the journal Journal of Neurochemistry found that Zeaxanthin dipalmitate, a wolfberry-derived carotenoid, can delay retinal degeneration in mice modelling Retinitis Pigmentosa mainly through its anti-inflammatory and oxidative stress effects. In the study's methodology, Zeaxanthin dipalmitate (ZD) was intravitreally injected into mice on postnatal day 16. Subsequent assessment of retinal function and structure were made at P25 using visual behavior tests, multi-electrode-array recordings, and immunostaining. The involved gene expressions and their regulation by ZD were delved into through transcriptome sequencing and western blotting.
In the discussion of results, it was discovered that ZD treatment significantly improved the visual behavior of the mice and delayed degeneration of the retinal photoreceptors, enhancing the light responses of photoreceptors, bipolar cells, and retinal ganglion cells. The ZD treatment led to a decline of up-regulated genes connected to inflammation, apoptosis, and oxidative stress. The study found that ZD reduces the activation of signal transducer and activator of transcription 3 and chemokine ligand 2, down-regulates the expression of the inflammatory factor GFAP, and withholds extracellular signal regulated protein kinases and P38, but not JNK pathways. All these findings indicate the potential of ZD as treatment for Retinitis Pigmentosa.
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Zeaxanthin dipalmitate, a wolfberry-derived carotenoid, can delay retinal degeneration in mice modelling Retinitis Pigmentosa mainly through its anti-inflammatory and oxidative stress effects.