Inflammatory Bowel Diseases

Presentation Slides

Chinese Medicine Research Hub

Carrageenan, a common food additive, has dual aspects, being both useful in drug delivery and food printing, while potentially harmful via inducing intestinal inflammatory conditions.

2024 Nutrients Carrageenan as a Potential Factor of Inflammatory Bowel Diseases
Komisarska P, Pinyosinwat A, Saleem M, Szczuko M

Chinese Medicine Research Hub

Systematic Review

Acupuncture and moxibustion therapy show greater effectiveness than oral sulphasalazine in treating inflammatory bowel diseases.

2013 Evidence-Based Complementary and Alternative Medicine Acupuncture and Moxibustion for Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Ji, J., Lu, Y., Liu, H., Feng, H., Zhang, F., Wu, L., Cui, Y., & Wu, H.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Inflammatory Bowel Diseases" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Inflammatory Bowel Diseases" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Inflammatory Bowel Diseases" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A published in 2024 in the journal Nutrients found that Carrageenan, a common food additive, has dual aspects, being both useful in drug delivery and food printing, while potentially harmful via inducing intestinal inflammatory conditions. This study investigates the dual roles of carrageenan, a naturally occurring polysaccharide. It is used in creating edible films and encapsulating drugs, and has potential uses in food printing. Moreover, it can regulate the composition of intestinal microflora, including promoting the increase of Bifidobacterium bacteria. The research shines a light on the harmful side of carrageenan as well by focusing on its interactive effects with intestinal microflora, mucous barrier, and proinflammatory pathways. The study reveals that carrageenan negatively alters intestinal microflora, triggering a breakdown of the mucus barrier, leading to an inflammatory response. This response occurs due to activation of the pro-inflammatory nuclear factor kappa-light-chain-enhancer pathway in the epithelial cells, likely via the mechanism of TLR4 receptor activation, alteration in macrophage activity, production of proinflammatory cytokines, and activation of innate immune pathways. Carrageenan's influence also led to increased levels of Bacteroidetes bacteria, alongside reducing short-chain fatty acid-producing bacteria, ultimately damaging the integrity of the intestinal membrane and reducing the mucin layer. The study finds that those with intestinal inflammation disorders, like Crohn's disease and ulcerative colitis, are particularly vulnerable to these harmful effects.

A Systematic Review published in 2013 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture and moxibustion therapy show greater effectiveness than oral sulphasalazine in treating inflammatory bowel diseases. For the methodology, seven significant databases, both domestic and international, were meticulously searched to accumulate and examine randomized controlled trials (RCTs). These trials specifically compared acupuncture and moxibustion as the main intervention to pharmacotherapy in treating Inflammatory bowel diseases (IBD). In total, 43 RCTs were incorporated and examined, 10 of which distinctly compared oral sulphasalazine with acupuncture or/and moxibustion treatments. In regards to the results received, the study found that acupuncture and moxibustion therapy displayed superior results when compared with oral sulphasalazine. This conclusion is drawn from the meta-analysis of the 10 trials focusing specifically on these treatments. Even though the systemic review presented several limitations and a definitive conclusion wasn't reached, it still laid groundwork for the potential effectiveness of acupuncture and moxibustion therapy in managing Inflammatory bowel diseases.

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