Acute Lung Injury
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Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway
2023 Jan Phytomedicine Li C, Li Y, Zhang H, Zhuo Y, Zhang L, Yang L, et al.
Xuanfei Baidu Decoction (XFBD) suppressed complement overactivation and ameliorated IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway. These data contribute to understanding the mechanisms of XFBD in COVID-19 treatment.
Network Pharmacology Xuan Fei Bai Du decoction COVID-19Huashibaidu formula attenuates sepsis-induced acute lung injury via suppressing cytokine storm: Implications for treatment of COVID-19
2023 Jan Phytomedicine Zhang F, Guo F, Zhang Y, Xu H, Liu Y, Lin L, et al.
The therapeutic mechanism of Huashibaidu formula (HSBD) against sepsis-induced acute lung injury (ALI) mainly involved suppressing cytokine storms and relieving inflammatory symptoms by regulating the expression of TLR4/NF-κB and PI3K/Akt. Our study provides a scientific basis for the mechanistic investigation and clinical application of HSBD in the treatment of sepsis and COVID-19.
Network Pharmacology Acute Lung Injury Hua Shi Bai Du formula Sepsis
Protective effect of Chrysanthemum morifolium Ramat. ethanol extract on lipopolysaccharide induced acute lung injury in mice
2020 Jul 25 BMC Complementary Medicine and Therapies Liu G, Zheng Q, Pan K, Xu X
Network Pharmacology Animal StudyChrysanthemum morifolium Ramat. ethanol extract (CEE) presents a potential protective effect on lipopolysaccharide induced acute lung injury in mice.
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Chrysanthemum morifolium Ramat. ethanol extract (CEE) presents a potential protective effect on lipopolysaccharide induced acute lung injury in mice.
2020 BMC Complementary Medicine and Therapies Protective effect of Chrysanthemum morifolium Ramat. ethanol extract on lipopolysaccharide induced acute lung injury in mice Liu G, Zheng Q, Pan K, Xu X
Network Pharmacology
Ninety male mice were randomly split into five groups and orally treated for seven days with control, model, and varying doses of CEE. On the last day of administration, all mice except the control group were infected intratracheally with lipopolysaccharide to induce acute lung injury. The experiment then measured factors such as lung histopathology, lung wet/dry weight, white blood cell count, and various immunity-related substances in the lung tissue.
The results revealed that CEE could improve lung damage as evident in histopathology, reduce ratio of lung wet to dry weight and other indices, and hinder the increase in white blood cells, lymphocytes, and neutrophils. It also reduced pro-inflammatory markers while increasing anti-inflammatory cytokines and substances related to antioxidant activity. The effects of CEE were seen to be dose-dependent, suggesting that larger doses provided more benefit.
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Chrysanthemum morifolium Ramat. ethanol extract (CEE) presents a potential protective effect on lipopolysaccharide induced acute lung injury in mice.
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